Article
Chemistry, Multidisciplinary
Chaolumen Wu, Qingsong Fan, Zhiwei Li, Zuyang Ye, Yadong Yin
Summary: This study demonstrates reversible assembly and active tuning of plasmonic chiral superstructures by introducing a chiral magnetic field. Manipulating the magnetic field controls both the chiral arrangement and spectral properties of the superstructures, enabling fast and reversible tunability.
MATERIALS HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Jingwen Wang, Junjie Yuan, Jiajia Liu, Haixia Zou, Lin Yang, Hong Chen, Xiangmeng Qu
Summary: DNA self-assembly is a promising method for constructing complex nanostructures. However, the current approach requires separate design and professional operation, limiting its development and application. In this study, a novel point-and-shoot strategy based on enzyme-assisted DNA paper-cutting was proposed to construct planar DNA nanostructures using the same DNA origami as a template. By annealing the long scaffold strand and selected staple strands, planar DNA nanostructures were successfully constructed. This strategy overcomes the complexity limitation of planar DNA nanostructures and simplifies the design and operation process. Overall, this strategy shows great potential for manufacturing DNA nanostructures.
Review
Engineering, Biomedical
Yun Zeng, Rachel L. Nixon, Wenyan Liu, Risheng Wang
Summary: DNA, as a molecular carrier of genetic information, can be fabricated into functional nanomaterials with a wide range of attributes and extremely low cytotoxicity. This review summarizes the applications of functionalized DNA nanostructures in bioimaging and tumor therapy, as well as discusses the remaining challenges and prospects.
Article
Chemistry, Multidisciplinary
Yuxiang Dong, Jiliang Liu, Xuanzhao Lu, Jialin Duan, Liqi Zhou, Lizhi Dai, Min Ji, Ningning Ma, Yong Wang, Peng Wang, Jun-Jie Zhu, Qianhao Min, Oleg Gang, Ye Tian
Summary: Self-assembly processes are important for fabricating complexly organized nanomaterials, but often limited in creating structures with multiscale order. In this study, a two-stage assembly strategy is introduced to successfully form complexly organized nanoparticle crystals.
Article
Chemistry, Multidisciplinary
Yong Wang, Xuehui Yan, Zhaoyu Zhou, Ningning Ma, Ye Tian
Summary: DNA nanotechnology allows for the assembly of 3D lattices with complex patterns, but altering their symmetries through non-thermal treatments is challenging. This study demonstrates the synthesis of DNA lattices with switchable shapes upon pH change, using octahedral DNA origami frames. The results show the feasibility of obtaining 3D lattices that respond to external stimuli.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Multidisciplinary Sciences
Lizhi Dai, Xiaoxue Hu, Min Ji, Ningning Ma, Hang Xing, Jun- Jie Zhu, Qianhao Min, Ye Tian
Summary: Harnessing the programmable nature of DNA origami, researchers have demonstrated the ability to control structural features in crystalline materials and achieve different equilibrium phases and shapes using a single DNA origami morphology. By modulating the binding coordination with an allosteric factor, the DNA origami crystals undergo phase transitions and yield diverse crystal systems. This approach opens up new possibilities for developing crystalline materials with tunable properties and accessing a rich phase space.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Daniel Fu, Raghu Pradeep Narayanan, Abhay Prasad, Fei Zhang, Dewight Williams, John S. Schreck, Hao Yan, John Reif
Summary: We have developed an automated design tool that can be applied to curved geometries for encapsulating three-dimensional DNA nanostructures. This research is significant in solving previous design challenges and expanding the application of DNA nanostructure design.
Review
Chemistry, Physical
Wenjing Jiang, Jingrou Li, Zi'an Lin, Jing Guo, Jiaxin Ma, Zhen Wang, Meizhou Zhang, Yuzhou Wu
Summary: In recent years, the development of DNA self-assembly technology has fueled the advancement of DNA origami technology. This technology enables the construction of DNA nanostructures with different shapes, which find wide applications in nanomaterial preparation and drug delivery. These structures possess accurate addressability, excellent programmability, and good biocompatibility, providing a highly precise platform for nanomaterial fabrication.
Article
Chemistry, Multidisciplinary
Joshua A. Johnson, Vasiliki Kolliopoulos, Carlos E. Castro
Summary: Simultaneous self-assembly of two distinct DNA origami nanostructures folded with the same scaffold strand was achieved in a single pot by adjusting concentrations of competing strands. The relative yields were correlated well with folding kinetics of individual structures, facilitating efficient fabrication of multi-structure systems and materials.
CHEMICAL COMMUNICATIONS
(2021)
Review
Engineering, Biomedical
Lingyu Feng, Jiang Li, Jielin Sun, Lihua Wang, Chunhai Fan, Jianlei Shen
Summary: Materials capable of regulating the composition and structure of cell membranes to create engineered cells with specific functions are highly sought after. DNA, with its outstanding programmability and biocompatibility, stands out among other biomolecules for cell membrane engineering. The near-atomic precision of DNA nanostructures allows for the exploration of structure-property relationships on cell membranes. This review summarizes the latest developments in functional DNA nanostructures and their application in modifying cell membrane morphology, controlling ion transport, and synthesizing highly precise liposomes. Challenges and prospects of using DNA nanostructures for cell membrane engineering are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biochemical Research Methods
Noemi Bellassai, Roberta D'Agata, Giuseppe Spoto
Summary: Nucleic acid nanotechnology focuses on designing and developing synthetic nucleic acid strands to create nanosized functional systems. The structural properties and conformational polymorphism of nucleic acid sequences make nucleic acid nanostructures attractive in biosensing applications. Recent advances in biosensing have been derived from molecular beacon and DNA origami structures, each offering unique characteristics and potentials in the field.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sofia Julin, Nonappa, Boxuan Shen, Veikko Linko, Mauri A. Kostiainen
Summary: Lipids play a crucial role in cellular compartments, and co-assembly of DNA origami with cationic lipids enhances the order and stability of lipid structures. This complexation strategy effectively protects DNA origami against nuclease digestion, opening up new possibilities for the construction of cell-membrane-associated components.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Renjie Niu, Chunyuan Song, Fei Gao, Weina Fang, Xinyu Jiang, Shaokang Ren, Dan Zhu, Shao Su, Jie Chao, Shufen Chen, Chunhai Fan, Lianhui Wang
Summary: This study introduces a DNA origami based nanoprinting strategy for transferring DNA strands to the surface of gold nanocubes, generating stereo-controlled gold nanostructures with specific geometry and composition for stronger surface enhanced Raman scattering signal amplification.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Fatih N. Gur, Susanne Kempter, Florian Schueder, Christoph Sikeler, Maximilian J. Urban, Ralf Jungmann, Philipp C. Nickels, Tim Liedl
Summary: The study demonstrates a DNA origami switch that utilizes the transition from double-stranded DNA to single-stranded DNA to drive a reversible conformational change. By using the unique properties of DNA, the switch exerts a contractive force produced by the extended single-stranded DNA to achieve large-scale motion. The operation of this switch is shown through various microscopy techniques, illustrating the intricate forces at play in nanoscale physical systems operating in fluids.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Lan Zhang, Xingyi Ma, Guoqing Wang, Xingguo Liang, Hideyuki Mitomo, Andrew Pike, Andrew Houlton, Kuniharu Ijiro
Summary: The revolutionary concept of non-biological DNA functioning in the material world has become a reality. Non-origami DNA has rich chemical functionality for constructing hybrid nano-architectures, and its potential in building functional nanostructures has been underestimated. Research in this area covers interactions of DNA with inorganic species, DNA nanofabrication, electronic nanodevices, metal nanoparticles, and chiral nanostructures, with applications ranging from plasmonic biosensing and electrical nanodevices to optical bioimaging and photocatalysis.
Article
Multidisciplinary Sciences
Shambhavi Shubham, Jan Hoinka, Soma Banerjee, Emma Swanson, Jacob A. Dillard, Nicholas J. Lennemann, Teresa M. Przytycka, Wendy Maury, Marit Nilsen-Hamilton
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Supipi Liyamali Auwardt, Yeon-Jung Seo, Muslum Ilgu, Judhajeet Ray, Robert R. Feldges, Shambhavi Shubham, Lee Bendickson, Howard A. Levine, Marit Nilsen-Hamilton
SCIENTIFIC REPORTS
(2018)
Article
Biophysics
Agnivo Gosai, Brendan Shin Hau Yeah, Marit Nilsen-Hamilton, Pranav Shrotriya
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Chemistry, Physical
Kalyan Santra, Ivan Geraskin, Marit Nilsen-Hamilton, George A. Kraus, Jacob W. Petrich
JOURNAL OF PHYSICAL CHEMISTRY B
(2019)
Article
Biochemistry & Molecular Biology
Muslum Ilgu, Shuting Yan, Ryan M. Khounlo, Monica H. Lamm, Marit Nilsen-Hamilton
Article
Multidisciplinary Sciences
Hyeong Jin Kim, Wenjie Wang, Wei Bu, Md Mir Hossen, Alejandra Londono-Calderon, Andrew C. Hillier, Tanya Prozorov, Surya Mallapragada, David Vaknin
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Multidisciplinary
Shuting Yan, Jason M. Peck, Muslum Ilgu, Marit Nilsen-Hamilton, Monica H. Lamm
Article
Chemistry, Medicinal
Meric Ozturk, Marit Nilsen-Hamilton, Muslum Ilgu
Summary: Neurological diseases are a major global health concern affecting over a billion people, with limited diagnosis and treatment options available. Aptamers, as small nucleic acid molecules that are easy to modify chemically, hold promise for future diagnostics and therapeutics for these diseases.
Article
Biochemistry & Molecular Biology
Sharif Anisuzzaman, Ivan M. Geraskin, Muslum Ilgu, Lee Bendickson, George A. Kraus, Marit Nilsen-Hamilton
Summary: The interaction between nucleic acids and molecular targets involves structural reorganization. Understanding this interaction is important for drug development. Polyfluorophenyl modifications have been found to enhance the ability of small molecule drugs to disrupt local RNA structures and promote remodeling.
Article
Biochemistry & Molecular Biology
Dilini Singappuli-Arachchige, Shuren Feng, Lijun Wang, Pierre E. Palo, Samuel O. Shobade, Michelle Thomas, Marit Nilsen-Hamilton
Summary: Magnetosomes of magnetotactic bacteria contain magnetic nanocrystals enclosed in vesicles. Mms6, a single magnetosome protein, has been found to direct the crystallization of magnetite nanoparticles in vitro. This study shows that Mms6 acts as a ferric reductase, reducing Fe3+ to Fe2+ to promote magnetite formation. The structure and multimeric state of Mms6 play a role in its iron reduction ability and iron binding characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Soma Banerjee, Mahsa Askary Hemmat, Shambhavi Shubham, Agnivo Gosai, Sivaranjani Devarakonda, Nianyu Jiang, Charith Geekiyanage, Jacob A. Dillard, Wendy Maury, Pranav Shrotriya, Monica H. Lamm, Marit Nilsen-Hamilton
Summary: The Ebola virus glycoprotein (GP) gene produces several mRNAs that generate different proteins, including a transmembrane protein and two secreted glycoproteins. Three structurally distinct aptamers were selected to bind with the secreted glycoprotein (sGP) and the transmembrane protein (GP1,2). These aptamers showed high affinity and selectivity for sGP and GP1,2 and could detect them with high sensitivity in the presence of serum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Alejandro Londono-Calderon, Md Mir Hossen, Pierre E. Palo, Lee Bendickson, Sandra Vergara, Marit Nilsen-Hamilton, Andrew C. Hillier, Tanya Prozorov