Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 14, Issue 5, Pages 1733-1742Publisher
ELSEVIER
DOI: 10.1016/j.nano.2018.04.019
Keywords
magnetic nanoparticles; drug delivery; chemotherapy; MRI-contrast agents; breast adenocarcinoma; iron oxide
Funding
- Russian Federation [MK-6371.2016.7]
- RSF [17-14-01316]
- Ministry of Education and Science of the Russian Federation in the framework of Increase Competitiveness Program of NUST MISiS [NoK2-2015-071, NoK4-2017-046]
- Russian Science Foundation [17-14-01316] Funding Source: Russian Science Foundation
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In presented paper we have developed new system for cancer theranostics based on vascular endothelial growth factor (VEGF) targeted magnetic nanoparticles. Conjugation of anti-VEGF antibodies with bovine serum albumin coated PEGylated magnetic nanoparticles allows for improved binding with murine breast adenocarcinoma 4T1 cell line and facilitates doxorubicin delivery to tumor cells. It was shown that intravenous injection of doxorubicin loaded VEGF targeted nanoparticles increases median survival rate of mice bearing 4T1 tumors up to 50%. On the other hand magnetic resonance imaging (MRI) of 4T1 tumors 24 h after intravenous injection showed accumulation of nanoparticles in tumors, thus allowing simultaneous cancer therapy and diagnostics. (C) 2018 Elsevier Inc. All rights reserved.
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