The ability of liposomes, tailored for blood–brain barrier targeting, to reach the brain is dramatically affected by the disease state

Multifunctional liposomes delay phenotype progression and prevent memory impairment in a presymptomatic stage mouse model of Alzheimer disease

(2017) Simona Mancini et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

(2016) Cláudia Saraiva et al.   JOURNAL OF CONTROLLED RELEASE

Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitor [18F]GSK2647544 in Healthy Male Subjects

(2016) Mickael Huiban et al.   MOLECULAR IMAGING AND BIOLOGY

Pulmonary administration of functionalized nanoparticles significantly reduces beta-amyloid in the brain of an Alzheimer’s disease murine model

(2016) Giulio Sancini et al.   Nano Research

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

Strategies for transporting nanoparticles across the blood–brain barrier

(2016) Tian-Tian Zhang et al.   Biomaterials Science

The detection of β-amyloid plaques in an Alzheimer's disease rat model with DDNP-SPIO

(2015) D. Zhang et al.   CLINICAL RADIOLOGY

Brain–blood ratio: implications in brain drug delivery

(2015) Abhijeet D Kulkarni et al.   Expert Opinion on Drug Delivery

Repeated intraperitoneal injections of liposomes containing phosphatidic acid and cardiolipin reduce amyloid-β levels in APP/PS1 transgenic mice

(2015) Lara Ordóñez-Gutiérrez et al.   Nanomedicine-Nanotechnology Biology and Medicine

In vitro and in vivo characterization of several functionalized ultrasmall particles of iron oxide, vectorized against amyloid plaques and potentially able to cross the blood-brain barrier: toward earlier diagnosis of Alzheimer's disease by molecular imag

(2014) Emilie Ansciaux et al.   Contrast Media & Molecular Imaging

Multifunctional Liposomes Reduce Brain  -Amyloid Burden and Ameliorate Memory Impairment in Alzheimer's Disease Mouse Models

(2014) C. Balducci et al.   JOURNAL OF NEUROSCIENCE

Potential Use of Polymeric Nanoparticles for Drug Delivery Across the Blood-Brain Barrier

(2013) G. Tosi et al.   CURRENT MEDICINAL CHEMISTRY

Tumor targeting and imaging with dual-peptide conjugated multifunctional liposomal nanoparticles

(2013) Rangger et al.   International Journal of Nanomedicine

Peroxisome Proliferator-activated Receptors and Alzheimer's Disease: Hitting the Blood–Brain Barrier

(2013) Juan M. Zolezzi et al.   MOLECULAR NEUROBIOLOGY

Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood–brain-barrier: Implications for therapy of Alzheimer disease

(2013) Laura Bana et al.   Nanomedicine-Nanotechnology Biology and Medicine

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The binding affinity of anti-Aβ1-42 MAb-decorated nanoliposomes to Aβ1-42 peptides in vitro and to amyloid deposits in post-mortem tissue

(2011) Mara Canovi et al.   BIOMATERIALS

Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide

(2011) Francesca Re et al.   JOURNAL OF BIOTECHNOLOGY

Design and potential application of PEGylated gold nanoparticles with size-dependent permeation through brain microvasculature

(2011) Arnold B. Etame et al.   Nanomedicine-Nanotechnology Biology and Medicine

Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model

(2011) Francesca Re et al.   Nanomedicine-Nanotechnology Biology and Medicine

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Lipid-based nanoparticles with high binding affinity for amyloid-β1–42 peptide

(2010) Marco Gobbi et al.   BIOMATERIALS