Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells

Systematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights into the Pathogenesis of Respiratory Syncytial Virus–Induced Lower Respiratory Tract Infections

(2017) Yingxin Zhao et al.   JOURNAL OF IMMUNOLOGY

Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression

(2017) Mario M. Müller et al.   Scientific Reports

Smoking-Associated Disordering of the Airway Basal Stem/Progenitor Cell Metabotype

(2016) Ruba S. Deeb et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Chronic inflammatory airway diseases: the central role of the epithelium revisited

(2016) S. T. Gohy et al.   CLINICAL AND EXPERIMENTAL ALLERGY

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses

(2016) Rachel A. Gottschalk et al.   Cell Systems

Quantitative Proteomics Reveals an Altered Cystic FibrosisIn VitroBronchial Epithelial Secretome

(2015) Jennifer R. Peters-Hall et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Barrier Epithelial Cells and the Control of Type 2 Immunity

(2015) Hamida Hammad et al.   IMMUNITY

Time- and compartment-resolved proteome profiling of the extracellular niche in lung injury and repair

(2015) H. B. Schiller et al.   Molecular Systems Biology

Respiratory epithelial cells orchestrate pulmonary innate immunity

(2015) Jeffrey A Whitsett et al.   NATURE IMMUNOLOGY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Plasticity of Airway Epithelial Cell Transcriptome in Response to Flagellin

(2015) Joan G. Clark et al.   PLoS One

Ward’s Hierarchical Agglomerative Clustering Method: Which Algorithms Implement Ward’s Criterion?

(2014) Fionn Murtagh et al.   JOURNAL OF CLASSIFICATION

Phosphoproteome Profiling of the Macrophage Response to Different Toll-Like Receptor Ligands Identifies Differences in Global Phosphorylation Dynamics

(2014) Virginie Sjoelund et al.   JOURNAL OF PROTEOME RESEARCH

A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4

(2014) Laia Alsina et al.   NATURE IMMUNOLOGY

Dectin-1 Is Expressed in Human Lung and Mediates the Proinflammatory Immune Response to Nontypeable Haemophilus influenzae

(2014) K. A. Heyl et al.   mBio

TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens

(2014) Ryan McClure et al.   Frontiers in Immunology

Changes in microRNA and mRNA Expression with Differentiation of Human Bronchial Epithelial Cells

(2013) Asuncion Martinez-Anton et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The human secretome atlas initiative: Implications in health and disease conditions

(2013) Kristy J. Brown et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Quantitative Assessment of In-solution Digestion Efficiency Identifies Optimal Protocols for Unbiased Protein Analysis

(2013) Ileana R. León et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomic Profiling of Bronchoalveolar Lavage Fluid in Critically Ill Patients with Ventilator-Associated Pneumonia

(2013) Elizabeth V. Nguyen et al.   PLoS One

Tumor and Endothelial Cell-Derived Microvesicles Carry Distinct CEACAMs and Influence T-Cell Behavior

(2013) Harrison T. Muturi et al.   PLoS One

Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons

(2013) Esther Klaile et al.   RESPIRATORY RESEARCH

Direct Proteomic Quantification of the Secretome of Activated Immune Cells

(2013) F. Meissner et al.   SCIENCE

Respiratory Infection and the Impact of Pulmonary Immunity on Lung Health and Disease

(2012) Joseph P. Mizgerd   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Extracellular vesicles in physiological and pathological conditions

(2012) Yuana Yuana et al.   BLOOD REVIEWS

Innate Immunity in the Respiratory Epithelium

(2011) Dane Parker et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

IFN-  Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway Disease

(2011) C. Mitchell et al.   JOURNAL OF IMMUNOLOGY

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

(2011) Vladimir Ramirez-Carrozzi et al.   NATURE IMMUNOLOGY

SignalP 4.0: discriminating signal peptides from transmembrane regions

(2011) Thomas Nordahl Petersen et al.   NATURE METHODS

The Structural Biology of Toll-like Receptors

(2011) Istvan Botos et al.   STRUCTURE

CEACAM1 deficiency delays important wound healing processes

(2011) Sarah LeBlanc et al.   WOUND REPAIR AND REGENERATION

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia

(2010) Alejandro A. Pezzulo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Implementation and evaluation of relative and absolute quantification in shotgun proteomics with label-free methods

(2010) Jonas Grossmann et al.   Journal of Proteomics

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

(2009) Mehmet Kesimer et al.   FASEB JOURNAL

Interferon-γ-Responsive Nonhematopoietic Cells Regulate the Immune Response to Mycobacterium tuberculosis

(2009) Ludovic Desvignes et al.   IMMUNITY

SPOCTOPUS: a combined predictor of signal peptides and membrane protein topology

(2008) Håkan Viklund et al.   BIOINFORMATICS

Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance

(2008) Rajesh K. Aneja et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phase Transfer Surfactant-Aided Trypsin Digestion for Membrane Proteome Analysis

(2008) Takeshi Masuda et al.   JOURNAL OF PROTEOME RESEARCH

CEACAM1 inhibits Toll-like receptor 2–triggered antibacterial responses of human pulmonary epithelial cells

(2008) Hortense Slevogt et al.   NATURE IMMUNOLOGY

Acute Lower Respiratory Tract Infection

(2008) Joseph P. Mizgerd   NEW ENGLAND JOURNAL OF MEDICINE

Microbial Patterns Signaling via Toll-Like Receptors 2 and 5 Contribute to Epithelial Repair, Growth and Survival

(2008) Renat Shaykhiev et al.   PLoS One

A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity

(2008) H. Negishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA