Article
Biotechnology & Applied Microbiology
ManLi Yuan, Bei Zhao, Huaping Jia, Can Zhang, Xiaowen Zuo
Summary: Sinomenine has been demonstrated to alleviate cardiac hypertrophy by activating the Nrf2/ARE signaling pathway, which leads to reduced cell area, decreased apoptosis rate, and regulation of gene and protein expression levels associated with cardiac hypertrophy. Further research is needed to confirm these findings in human subjects.
Article
Food Science & Technology
Wenlin Xu, Hao Zheng, Youtian Fu, Yayi Gu, Hui Zou, Yan Yuan, Jianhong Gu, Zongping Liu, Jianchun Bian
Summary: This study demonstrates that resveratrol (RSV) can protect cells and alleviate oxidative stress and apoptosis induced by zearalenone (ZEA) through the PI3K/Akt signaling pathway.
Article
Immunology
Qiwen Yu, Sanyang Chen, Hongwei Tang, Xiaodan Zhang, Ruolin Tao, Zhiping Yan, Jihua Shi, Wenzhi Guo, Shuijun Zhang
Summary: Veratric acid (VA) has protective effects against liver ischemia/reperfusion (I/R) injury by activating the Nrf2 signaling pathway, leading to increased expression of Nrf2, HO-1, and NQO-1 proteins, which helps alleviate oxidative stress and apoptosis, thus reducing liver damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lina Xing, Hengjiang Guo, Sixuan Meng, Bingbing Zhu, Ji Fang, Jiebo Huang, Junliang Chen, Yunman Wang, Li Wang, Xingmei Yao, Hao Wang
Summary: Klotho activates the Nrf2 signaling pathway to inhibit oxidative stress and apoptosis induced by high glucose, thus protecting podocytes. This protective effect may be targeted by activating Nrf2 for the treatment of diabetic nephropathy (DN).
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Dan Shao, Zhen Gao, Ying Zhao, Mingzhen Fan, Xiaoe Zhao, Qiang Wei, Menghao Pan, Baohua Ma
Summary: Oxidative stress in high-yielding dairy goats negatively affects lactation length, milk quality, and dairy product economics. Sulforaphane (SFN), found in broccoli, shows promise as an antioxidant for clinical applications. This study investigated the effects of SFN on H2O2-induced oxidative damage in GMECs and the underlying molecular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Bani Ismail, Peramaiyan Rajendran, Hamad Mohammed AbuZahra, Vishnu Priya Veeraraghavan
Summary: The study evaluated the effects of Mangiferin on DOX-induced cytotoxicity in HUVECs and found that MGN significantly increased Nrf2 expression through upregulating the PI3K/AKT pathway, thereby reducing cell apoptosis induced by DOX.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Yang Zhang, Shan Liu, Jiu-Long Ma, Chen Chen, Peng Huang, Jia-Hua Ji, Di Wu, Li-Qun Ren
Summary: Apocynum venetum L. leaf extract alleviates doxorubicin-induced cardiomyocyte apoptosis by suppressing oxidative stress and apoptosis through the AKT/Bcl-2 signaling pathway.
Article
Pharmacology & Pharmacy
Zhihui Liu, Bendong Shi, Yu Wang, Qingyang Xu, Hongxin Gao, Jun Ma, Xiaowen Jiang, Wenhui Yu
Summary: Curcumin has been shown to alleviate aristolochic acid I-induced renal injury in rats by activating the SIRT1/Nrf2/HO-1 signaling pathway.
Article
Pharmacology & Pharmacy
Qixiang Yue, Xia Chen, Jianmei Gao, Qihai Gong, Jingshan Shi, Fei Li
Summary: In this study, the effect of dendrobine, the main active component of Dendrobium Nobile, on oxidative damage in skin was investigated using a keratinocyte cell line. It was found that dendrobine reduced the level of reactive oxygen species and decreased cell apoptosis in HACAT cells. The antioxidant effect of dendrobine was related to the up-regulation of antioxidant enzymes and the activation of the Nrf2/Keap1 signaling pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Food Science & Technology
Rong Yan, Hanli Wang, Jiangning Zhu, Tiancheng Wang, Eugenie Nepovimova, Miao Long, Peng Li, Kamil Kuca, Wenda Wu
Summary: This study assessed the effects of procyanidins (PC) on cell apoptosis caused by zearalenone (ZEA) and validated the role of Nrf2 in this process. The findings demonstrated that PC could enhance the cell antioxidant capacity, mitigate ZEA-induced cell apoptosis, and promote the expression of Nrf2 and its downstream genes. This discovery contributes to the clinical application of PC in preventing reproductive toxicity caused by ZEA.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Zhiqiang Feng, Tengfei Wang, Yawen Sun, Siying Chen, Haisheng Hao, Weihua Du, Huiying Zou, Dawei Yu, Huabin Zhu, Yunwei Pang
Summary: Sulforaphane (SFN), extracted from cruciferous plants, plays a vital role in eliminating oxidative free radicals and protecting cells through activation of the Nrf2-mediated signaling pathway. This study found that SFN can attenuate paraquat-induced damage to bovine in vitro-matured oocytes and enhance their maturation and fertilization rates. SFN reduces oxidative stress, inhibits cell apoptosis, and activates antioxidative-related genes through the Nrf2 pathway, providing novel evidence for the protective role of SFN against paraquat-induced injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Yuanming Wang, Jiao Yue, Chun Chen, Yingjuan Hao
Summary: Naringenin may protect against retinal damage in diabetic rats by regulating protein expressions of the nuclear factor erythroid 2-related factor 2/antioxidant response element signaling pathway, thereby resisting oxidative damage and reducing cell apoptosis in retinal tissues.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Environmental Sciences
Qirui Zhang, Shengchen Wang, Fuhan Wang, Mengyao Guo, Shiwen Xu
Summary: TBBPA is a widely used substance that accumulates in the environment and causes extensive damage to organisms. It induces oxidative stress, tissue damage, and cell death, affecting the physiological function of tissues. In this study, mouse skeletal muscle models and mouse myoblast cell models were used to demonstrate that TBBPA treatment increases reactive oxygen species and Malondialdehyde levels while decreasing antioxidant enzyme activities. TBBPA inhibits Nrf2 entry into the nucleus, leading to increased expression of inflammatory factors and decreased expression of anti-apoptotic factors. Programmed necrosis-related factors are also elevated. TBBPA induces oxidative stress, inflammation, apoptosis, and necrosis in mouse skeletal muscle through the Nrf2/ROS/TNF-alpha signaling pathway.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cell & Tissue Engineering
Yanting Sun, Hao Xu, Bin Tan, Qin Yi, Huiwen Liu, Tangtian Chen, Han Xiang, Rui Wang, Qiumin Xie, Jie Tian, Jing Zhu
Summary: This study aimed to illustrate the protective effect of andrographolide (AG) against glucose and serum deprivation under hypoxia (GSDH)-induced cell injury in BMSCs and investigate the possible underlying mechanisms. The results showed that AG can protect BMSCs from GSDH-induced cell injury by increasing cell viability and proliferation, enhancing mitochondrial function, and reducing apoptosis and oxidative stress.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zhiyin Wang, Bin Cai, Chenrui Cao, Haining Lv, Yimin Dai, Mingming Zheng, Guangfeng Zhao, Yanfang Peng, Wenjing Gou, Jingmei Wang, Dan Liu, Yali Hu
Summary: The study demonstrated that CD151 is a key regulator of antioxidants in the placenta, and its expression levels are negatively correlated with the expression of antioxidant genes in PE patients. CD151 may be a new target for PE treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Chemistry, Medicinal
Jing Cai, Rong Yan, Jichao Shi, Jia Chen, Miao Long, Wenda Wu, Kamil Kuca
Summary: With the increasing awareness of food safety and environmental protection, plant essential oils have attracted interest due to their advantages such as no residue, high efficiency, antioxidant properties, etc. The application of plant essential oils in degrading mycotoxin toxicity has garnered more attention, with studies focusing on their inhibitory effects on various mycotoxins. Research progress in recent years has been summarized to provide reference for the application of plant essential oils in combating fungi and mycotoxins.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cell Biology
Yan Wang, Jiaxi Lin, Ziyang Cheng, Tiancheng Wang, Jia Chen, Miao Long
Summary: This study found that Bacillus coagulans TL3 can protect the intestine from inflammation and oxidative damage caused by LPS by regulating signaling pathways, inhibit the reproduction of harmful bacteria by regulating the growth of intestinal flora, and enhance intestinal immunity.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Chemistry, Multidisciplinary
Ping Ou, Fangzhen Song, Yuhuan Yang, Junqi Shao, Yusen Hua, Shuhua Yang, Hebin Wang, Yudong Luo, Jian Liao
Summary: A one-step hydrothermal method is used to prepare WO3·nH2O crystals with different morphologies/phases, without the need for surfactants, templates, or structuredirecting agents. By adjusting the amount of H2SO4 and reaction temperature, various types of WO3·nH2O crystals are obtained, and the formation mechanism is proposed. The optical absorption properties of these crystals are also investigated.
Article
Chemistry, Physical
Lin Liu, Yongju Gao, Yikun Liu, Meiling Xu, Shuhua Yang, Kui Li, Songfang Zhao, Duxia Cao, Jong-Hyun Ahn
Summary: This study presents a versatile strain-sensing platform using metal-organic framework-derived porous carbon-welding carbon nanotubes (MPC-w-CNTs) percolation networks. The platform shows excellent sensing performances, detecting a wide range of deformations with high sensitivity and short response time. The unique junction bonding strategy offers potential for developing stretchable electronics using other nanomaterial systems.
APPLIED SURFACE SCIENCE
(2022)
Article
Energy & Fuels
Shuo Zhang, Wenqian Xu, Shuhua Yang, Fuan Lu, Huashu Dou
Summary: The total bending angle of a tandem cascade diffuser significantly influences the performance of the compressor stage, and the 10 degrees model achieves the best performance.
Article
Materials Science, Multidisciplinary
Le Zhang, Shuhua Yang, Wenqing Fu, Yanwei Cui, Jieqiang Wang, Degang Zhao, Chao Yang, Xiutong Wang, Bingqiang Cao
Summary: This study demonstrates a facile plasma-induced strategy to introduce oxygen vacancies into epsilon-MnO2, resulting in oxygen vacancies-rich epsilon-MnO2 nanosheets (epsilon-MnO2-x) with satisfactory electrochemical performance. The synergistic effect of oxygen vacancies and exposed free-standing collector enables the epsilon-MnO2-x nanosheets electrode to deliver remarkable capacity, ultrahigh energy density, and impressive durability, making it a promising strategy for designing advanced metal oxide electrode materials for high-performance aqueous zinc ion batteries.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Microbiology
Jia Chen, Jing Cai, Jiaxi Lin, Ziyang Cheng, Miao Long
Summary: This study aimed to investigate the effect and mechanism of Bacillus coagulans TL3 (B. coagulansTL3) on ileal inflammatory injury induced by lipopolysaccharide (LPS). The results showed that both high-concentration and low-concentration TL3 strains significantly reversed the changes in biochemical indices, pathological changes, and protein expressions induced by LPS, indicating that TL3 strain could protect against ileal oxidative stress and inflammation induced by LPS, possibly through inhibition of the TLR4/MyD88 signaling pathway.
CURRENT MICROBIOLOGY
(2023)
Article
Chemistry, Physical
Shuhua Yang, Yanwei Cui, Guangxu Yang, Songfang Zhao, Jieqiang Wang, Degang Zhao, Chao Yang, Xiutong Wang, Bingqiang Cao
Summary: In this study, a hierarchical porous carbon induced by ZnCl2 from corncob cellulose is developed through a single-step activation process. The material exhibits suitable micropores for high energy storage and sufficient mesopores for high-rate performance, thereby improving the performance of zinc-ion hybrid supercapacitors. The optimized hierarchical porous carbon shows high specific capacity, high energy density, and good cycling stability. The assembled quasi-solid-state flexible hybrid supercapacitor also demonstrates high specific capacity, satisfactory mechanical properties, and promising application prospects.
JOURNAL OF POWER SOURCES
(2023)
Article
Food Science & Technology
Yuhang Sun, Zhaoran Yao, Miao Long, Ying Zhang, Kehe Huang, Lin Li
Summary: Aflatoxin B1 (AFB1), a common mycotoxin in food and feed, poses significant threats to human and animal health. Previous studies have shown that AFB1 can promote influenza virus replication and induce alveolar macrophages polarization. This study demonstrates that alveolar macrophages play a crucial role in the early stage promotion of SIV infection by AFB1 and AFB1 can promote SIV replication by inducing alveolar macrophages to polarize towards M1 macrophages.
Article
Chemistry, Physical
Guangxu Yang, Shuhua Yang, Jian Shen, Yanwei Cui, Jinfeng Sun, Guangbin Duan, Bingqiang Cao, Zongming Liu
Summary: Due to its high safety and low cost, aqueous Zn-ion batteries (AZIBs) have become one of the most promising energy storage devices. In this study, a stable cathode with fast kinetics and high-energy density, KOH-induced oxygen-deficient VO2 (K-VO2), was developed. The K-VO2 cathode achieved improved kinetics and enhanced Zn-ion storage capability through unique morphology, abundant active sites, and oxygen vacancy. The optimized K-VO2-3:4 demonstrated excellent electrochemical performance, indicating the potential of the KOH activation strategy for developing high-energy and stable cathodes.
ACS APPLIED ENERGY MATERIALS
(2023)
Review
Food Science & Technology
Yuhang Sun, Yuqi Song, Miao Long, Shuhua Yang
Summary: Aflatoxin B1 (AFB1), ochratoxin A (OTA), and deoxynivalenol (DON) are the three most studied mycotoxins that have significant immunotoxicity and impact on pathogen infection. The determining factors for their immunotoxicity include exposure doses and times, species, sex, and immunologic stimulants. These mycotoxins can also aggravate the severity of infection caused by bacteria, viruses, and parasites. Their mechanisms of action involve promoting pathogen proliferation, inducing inflammatory response, and suppressing specific immune cells. This review provides a scientific foundation for controlling these mycotoxins and understanding subclinical infections.
Review
Agriculture, Dairy & Animal Science
Huiying Sun, Ziqi He, Dongwei Xiong, Miao Long
Summary: This article summarizes the newly discovered degrading enzymes that can degrade four common mycotoxins in the past five years, and explains their degradation mechanisms and positive effects on animal production.
Article
Chemistry, Multidisciplinary
Liying Yin, Zenglong Xu, Guangxu Yang, Fuhai Guo, Wenhui Guo, Songfang Zhao, Shuhua Yang
Summary: In this work, electrospun VO2/carbon fibers with a three-dimensional network structure were obtained and used as cathode materials for aqueous zinc-ion batteries. The carbon fiber network significantly improved the conductivity and stability of VO2, resulting in a higher specific capacity compared to pure VO2. Excellent capacity retention at high current density was also achieved.
Article
Chemistry, Physical
Guangxu Yang, Shuhua Yang, Jinfeng Sun, Guangbin Duan, Bingqiang Cao, Zongming Liu
Summary: Aqueous Zn-ion batteries (AZIBs) have emerged as a promising energy storage solution due to their high safety and low cost. This study presents a one-step hydrothermal method to develop W-doped VO2 cathodes, which exhibit improved kinetics and long cycle life. The W-VO2 cathode demonstrates high capacity, excellent high-rate capability, and long-term cycling stability, outperforming pure VO2. The W doping strategy proposed in this work offers a promising pathway for developing other high-energy and stable cathodes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Guangxu Yang, Shuhua Yang, Jinfeng Sun, Guangbin Duan, Bingqiang Cao, Zongming Liu
Summary: Aqueous Zn-ion batteries (AZIBs) are gaining attention as promising energy storage devices due to their high safety and low cost. This study successfully developed a W-doped VO2 cathode material (W-VO2) through a one-step hydrothermal method, which exhibits improved kinetics, high energy density, and long cycle life. The W doping strategy proposed here also shows potential for developing other high-energy and stable cathodes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
