Article
Crystallography
Sonali Sharma, Mithra N. Hegde, Sindhu Ramesh
Summary: This article discusses preventive and management strategies for dental caries, emphasizing the importance of effective remineralization protocols, and introduces the use of aluminum gallium arsenide crystal irradiation with LASER to alter enamel crystal structure and enhance acid resistance.
Article
Biochemistry & Molecular Biology
Seonghye Kim, Yuri Song, Seyeon Kim, Siyeong Kim, Heesam Na, Sujin Lee, Jin Chung, Suhkmann Kim
Summary: Several studies have shown that nuclear magnetic resonance (NMR) metabolic profiles can differentiate patients with caries from healthy individuals. This study aimed to identify a salivary metabolite biomarker panel for early childhood caries (ECC). Saliva samples from children with and without caries were analyzed using NMR spectroscopy, and specific metabolites were identified that could detect ECC. An optimal biomarker panel comprising formate, lactate, proline, and glycine was developed, which showed improved diagnostic performance for ECC compared to a single metabolite.
Review
Medicine, Research & Experimental
Gisela Nataly Rubin De Celis-Quintana, Adriana Moreno-Rodriguez, Rafael Torres-Rosas, Liliana Argueta-Figueroa
Summary: The study evaluated the anti-cariogenic effect of arginine-containing toothpastes and found that toothpastes containing a combination of fluoride and arginine have a greater protective effect against cavities, reducing the development of caries, increasing the activity of arginine deiminase system, promoting enamel remineralization, and decreasing lactic acid production, with no reported significant side effects.
INVESTIGACION CLINICA
(2021)
Article
Biochemistry & Molecular Biology
Ravichellam Sangavi, Sankar Muthumanickam, Nambiraman Malligarjunan, Ravi Jothi, Pandi Boomi, Seenichamy Arivudainambi, Muthusamy Raman, Chaitanya G. Joshi, Shunmugiah Karutha Pandian, Shanmugaraj Gowrishankar
Summary: This study is the first to demonstrate the potential of fatty acids as promising anti-caries agents using in silico data. Through virtual screening, molecular dynamics simulation, and binding free energy prediction, the best fatty acid ligands for three protein targets associated with Streptococcus mutans were identified. Further analysis indicated that these fatty acids have stable binding affinity and biological feasibility as therapeutic candidates.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Microbiology
Muna Aqawi, Ronit Vogt Sionov, Ruth Gallily, Michael Friedman, Doron Steinberg
Summary: The study demonstrated that Cannabigerol (CBG) can effectively prevent the formation of Streptococcus mutans biofilms, reduce biofilm thickness and metabolic activity, and alter the surface roughness of the biofilms. CBG also decreased the expression of genes related to S. mutans biofilm formation, indicating its potential as a preventive treatment for dental caries.
Article
Biochemistry & Molecular Biology
Min Young Kim, In Kyung Hyun, Sunghyun An, Donghan Kim, Ki Hwan Kim, Seok-Seong Kang
Summary: This study found that BLs extracted from Lactobacillus plantarum and L. rhamnosus GG can suppress periodontal inflammation and interfere with biofilm formation by Streptococcus mutans. BLs regulate the MAPK and NF-kappa B signaling pathways and reduce the synthesis of extracellular polysaccharide, thereby improving oral health.
Article
Chemistry, Analytical
Philipp Nitschke, Samantha Lodge, Drew Hall, Hartmut Schaefer, Manfred Spraul, Nieves Embade, Oscar Millet, Elaine Holmes, Julien Wist, Jeremy K. Nicholson
Summary: A JEDI NMR pulse experiment was conducted on a low field spectrometer system to quantitatively measure two plasma markers of SARS-CoV-2 infection and inflammation. The experiment successfully captured the unique biomarker signals and showed comparable results to high field machines. Simplification of sample preparation allowed for shorter testing time and high-throughput capability.
Article
Microbiology
Muna Aqawi, Ronit Vogt Sionov, Ruth Gallily, Michael Friedman, Doron Steinberg
Summary: CBG exhibits antibacterial activities against S. mutans by altering membrane structures and properties, increasing membrane permeability, reducing metabolic activity, and preventing pH drop caused by the bacteria.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yu Xu, Jiawei Guan, Qi Wang, Rui Xue, Zhirong He, Xin Lu, Jingmin Fan, Hang Yu, Chimengul Turghun, Wei Yu, Zhijian Li, Sirapil Abay, Wen Chen, Bo Han
Summary: This study proposes a multifunctional strategy to treat dental caries by constructing a bioactive tooth surface. The Turkish gall extract (TGE) is able to inhibit the adhesion of cariogenic bacteria and destroy biofilms on the tooth surface, while also reducing the expression of inflammatory factors. Furthermore, TGE can induce the growth of hydroxyapatite crystals, leading to the remineralization of enamel and the restoration of mechanical properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Ian W. Burton, Mohsen Kompany-Zareh, Sophie Haverstock, Jonathan Hache, Camilo F. Martinez-Farina, Peter D. Wentzell, Fabrice Berrue
Summary: To address the issue of honey adulteration, a quantitative NMR method was developed to analyze honey samples collected in Canada. Multivariate statistical methods were used to differentiate Canadian honey from other honeys.
Article
Chemistry, Multidisciplinary
Dilek Eltemur, Peter Robatscher, Michael Oberhuber, Alberto Ceccon
Summary: NMR spectroscopy is a powerful analytical tool for identifying and quantifying natural compounds in food matrices. However, its low intrinsic sensitivity makes it challenging to detect adulterants or markers for authenticity at low concentrations. This study presents a simple solution to enhance the sensitivity of NMR and successfully applies it to the authentication of milk products.
Article
Materials Science, Biomaterials
Y. D. Chen, C. Shu, Z. H. Duan, J. J. Xu, X. J. Li, F. Chen, Q. J. Luo, X. D. Li
Summary: PHMB-F, a fluorine-containing cationic polymer, has been synthesized to combine the benefits of fluoride with the antibacterial properties of PHMB. This new compound shows improved antiseptic efficacy against Streptococcus mutans compared to PHMB alone. By allowing fluoride ions to exist closer to the enamel surface, PHMB-F reduces ion concentrations in the microenvironment adjacent to hard dental tissues, requiring only low concentrations for enamel remineralization.
BIOMATERIALS SCIENCE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Oscar Musalem-Dominguez, Jose Maria Montiel-Company, Veronica Ausina-Marquez, Jose Manuel Morales-Tatay, Jose Manuel Almerich-Silla
Summary: This study identified metabolomic differences in saliva between healthy children and children with active carious lesions, and developed a predictive model based on the salivary metabolomic profile. The results showed differences in metabolites, particularly saccharides and amino acids, between the two groups, suggesting their association with caries risk. These findings contribute to the research of salivary biomarkers, caries risk assessment, and personalized prevention strategies.
JOURNAL OF DENTISTRY
(2023)
Article
Materials Science, Multidisciplinary
Zehui Fang, Yuyuan Zhang, Chris Ying Cao, Quan Li Li, Hai Ming Wong
Summary: A multi-functional membrane formed by the combination of lysozyme and polyphemusin I demonstrates superior abilities in inhibiting the growth of S. mutans and inducing tooth remineralization, offering a promising strategy for preventing dental caries.
MATERIALS & DESIGN
(2022)
Article
Medicine, General & Internal
Claudia Cobos, Paramjit S. Bansal, David T. Wilson, Linda Jones, Guangzu Zhao, Matthew A. Field, Ramon M. Eichenberger, Darren A. Pickering, Rachael Y. M. Ryan, Champa N. Ratnatunga, John J. Miles, Roland Ruscher, Paul R. Giacomin, Severine Navarro, Alex Loukas, Norelle L. Daly
Summary: The decrease in parasites such as hookworms is associated with the rise of non-communicable inflammatory conditions. Proteins produced by hookworms have been found to suppress inflammatory bowel disease and asthma. Researchers have discovered that certain peptides derived from hookworm proteins exhibit anti-inflammatory effects and therapeutic activity in a mouse model of acute colitis. These findings have the potential to lead to improved treatments for inflammatory conditions.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemical Research Methods
Khye Er Loh, Yong Sin Chin, Intan Safinar Ismail, Hui Yin Tan
Summary: Hyperuricemia is the key risk factor for gout, and finding safer and more effective alternatives for current treatments is urgent. This study compared the metabolite profiles of Chrysanthemum morifolium flower fraction and its detannified fraction in relation to XO inhibitory activity, finding that the ethyl acetate fraction showed the highest XO inhibitory activity. The study identified potential compounds responsible for XO inhibition and demonstrated an additive interaction between 4-hydroxybenzoic acid and apigenin or kaempferol in XO inhibition.
PHYTOCHEMICAL ANALYSIS
(2022)
Article
Neurosciences
Ibrahim Mohammed Badamasi, Maulidiani Maulidiani, Munn Sann Lye, Normala Ibrahim, Khozirah Shaari, Johnson Stanslas
Summary: This study analyzed urine and serum samples from healthy controls and MDD patients using 1HNMR spectroscopy, and identified changes in metabolite levels that have potential diagnostic value for MDD, including decreased levels of lactate, glutamine, creatinine, valine, alanine, and fatty acid, as well as an increased level of acetone and choline in the serum of MDD patients.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hanaa Ali Hussein, Murni Nur Islamiah Kassim, M. Maulidiani, Faridah Abas, Mohd Azmuddin Abdullah
Summary: This study evaluated the cytotoxic activity of Tamoxifen (TMX) in combination with microalgal crude extracts (MCEs) on breast cancer cells and non-cancerous cells. The results showed that the synergistic application of MCEs with TMX can maintain the cytotoxicity against breast cancer cells while reducing the toxicity against non-cancerous cells.
Article
Biochemistry & Molecular Biology
Kai Song Ng, Sheri-Ann Tan, Chui Yin Bok, Khye Er Loh, Intan Safinar Ismail, Chen Son Yue, Chui Fung Loke
Summary: Antioxidants, particularly from Clinacanthus nutans leaves, show potential in preventing liver cancer in NAFLD patients. The study identified strong radical scavenging and reducing power properties in CNL compared to CNS, with the presence of specific metabolites contributing to antioxidant and hepatoprotective abilities. HepG2 cell model further supported the effectiveness of CNL in reducing ROS levels and protecting liver cells from oxidative stress.
Article
Chemistry, Medicinal
Ka Woong Wong, Soek Sin Teh, Kung Pui Law, Intan Safinar Ismail, Kohei Sato, Nobuyuki Mase, Siau Hui Mah
Summary: Oxidative stress and inflammation are critical in the development of various diseases. In this study, novel compounds with strong antioxidant and anti-inflammatory properties were synthesized, and a specific substituent was found to play a key role in their activities. Compound 4b was identified as a potential lead compound for further drug development.
ARCHIV DER PHARMAZIE
(2023)
Article
Biochemistry & Molecular Biology
Fauziahanim Zakaria, Muhammad Tayyab Akhtar, Wan Ibrahim Wan Norhamidah, Abu Bakar Noraini, Azira Muhamad, Shamarina Shohaimi, Maulidiani, Hafandi Ahmad, Intan Safinar Ismail, Nor Hadiani Ismail, Khozirah Shaari
Summary: Depression is a common mental disorder that negatively affects psychosocial function and quality of life. The exact cause and mechanism of depression are still unclear, but stress is known to play a major role. Current antidepressant drugs often have side effects. Centella asiatica has shown promise as an antidepressant in animal studies.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Siok-Geok Chong, Intan S. Ismail, Amalina Ahmad Azam, Shih-Jen Tan, Khozirah Shaari, Jen-Kit Tan
Summary: This study investigated the chemical profiles of non-organic and organic soybeans, and the changes in metabolites after fermentation. The results showed no significant difference in the chemical profiles between non-organic and organic soybeans. However, the metabolite profile of unfermented soybeans shifted to higher amino acid and organic acid content after fermentation, potentially enhancing their nutritional value.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Kholis Abdurachim Audah, Jufendi Ettin, Jason Darmadi, Norma Nur Azizah, Amalda Siti Anisa, Tedi Dwi Fauzi Hermawan, Conny Riana Tjampakasari, Rudi Heryanto, Intan Safinar Ismail, Irmanida Batubara
Summary: This study investigated the anti-MRSA and antioxidant activity of Indonesian mangrove species. The ethanol solvent-based Sonneratia caseolaris leaves extract showed the highest antioxidant and anti-MRSA activities. The extract contained a significant amount of polyphenols associated with antioxidative and antibacterial properties.
Article
Plant Sciences
Nur Khaleeda Zulaikha Zolkeflee, Pei Lou Wong, M. Maulidiani, Nurul Shazini Ramli, Azrina Azlan, Faridah Abas
Summary: This study aims to investigate the antidiabetic potential of Muntingia calabura (MC) on a STZ-NA-induced diabetic rat model. Treatment with MC extract showed favorable serum creatinine, urea, and glucose lowering capacity. Metabolomic analysis identified nine biomarkers that distinguish between diabetic control and normal groups. The induction of diabetes altered various metabolic pathways, but treatment with MC extract improved carbohydrate metabolism and other metabolic pathways.
Article
Food Science & Technology
Muhammad Faiz Zulkifli, Mohanasundarapandian Sivakumar, M. Maulidiani, Wan Iryani Wan Ismail
Summary: Trehalulose is a naturally occurring disaccharide composed of fructose and glucose. It has a unique α-1,1 glycosidic bond, making it more stable than sucrose and resulting in a lower glycemic index. Recent research has revealed the abundance of trehalulose in stingless bee honey, leading to its increasing popularity. This review discusses the chemical and physiological properties of trehalulose, its potential health benefits, and its antidiabetic potential as an emerging alternative sweetener.
Article
Biochemical Research Methods
Ilya Iryani Mahmod, Intan Safinar Ismail, Yahaya M. Normi, Siok-Geok Chong
Summary: This study assessed the nephroprotective effects of Clinacanthus nutans leaf extracts on kidney cells and found that it regulates glycerophospholipid, purine, and amino acid metabolism, as well as the glycolysis pathway.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Chemistry, Applied
Nurul Najihah Husna Tanazi, Ahmad Nazif Aziz, Mohamad Nurul Azmi, Mohamad Hafizi Abu Bakar, Muhamad Fairus Noor Hassim, Nurul Huda Abdul Wahab, Nurulfazlina Edayah Rasol, Nurunajah Ab Ghani, M. Maulidiani, Khalijah Awang
Summary: Phytochemical investigation on the bark of E. kingiana plant led to the discovery of ten compounds, including polyketides, endiandric acids, and a sesquiterpene. One of the sesquiterpenes may be the first report on its presence in the Endiandra genus. In addition, one compound exhibited significant inhibitory activity against both alpha-amylase and alpha-glucosidase enzymes.
NATURAL PRODUCT RESEARCH
(2023)
Article
Fisheries
Abdul Razak Rashidah, Mohamed Shariff, Fatimah Md. Yusoff, Intan Safinar Ismail
Summary: The study shows that supplementing fish feed with Polygonum chinense extract can significantly enhance the immune competence and disease resistance of Asian seabass, as well as improve their hematological profile. This finding is of great importance for the development of aquaculture.
FISH AND SHELLFISH IMMUNOLOGY REPORTS
(2023)
Article
Food Science & Technology
Mohd Azam, Che Soh, H. S. Rapi, N. Ismail, A. Z. Jusoh, M. N. Haron, A. M. Ali, M. Maulidiani, W. I. W. Ismail
Summary: This study evaluated the effects of daily consumption of kelulut honey on health through animal experiments. The results showed that daily consumption of kelulut honey had no toxicity and had beneficial effects on food intake, weight gain, and immune function. Kelulut honey can be safely consumed at a high dose.
INTERNATIONAL FOOD RESEARCH JOURNAL
(2022)
Article
Chemistry, Medicinal
Nur Khaleeda Zulaikha Zolkeflee, M. Maulidiani, Leng Wei Khoo, Khozirah Shaari, Faridah Abas
CHEMISTRY OF NATURAL COMPOUNDS
(2022)
