Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation

Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer

(2018) Hadia Almahli et al.   BIOORGANIC CHEMISTRY

Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation

(2018) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies

(2017) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells

(2017) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation

(2017) Ghada H. Al-Ansary et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives

(2016) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation

(2016) Sahar M. Abou-Seri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII

(2016) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Cytotoxic Activity of Biphenylurea Derivatives Containing Indolin-2-one Moieties

(2016) Wagdy Eldehna et al.   MOLECULES

2-((Benzimidazol-2-yl)thio)-1-arylethan-1-ones: Synthesis, crystal study and cancer stem cells CD133 targeting potential

(2015) Hatem A. Abdel-Aziz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking

(2015) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents

(2015) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Designing carbonic anhydrase inhibitors for the treatment of breast cancer

(2015) Claudiu T Supuran et al.   Expert Opinion on Drug Discovery

Design, Synthesis and Antitubercular Activity of Certain Nicotinic Acid Hydrazides

(2015) Wagdy Eldehna et al.   MOLECULES

Synthesis, biological evaluation and molecular modeling of novel series of pyridine derivatives as anticancer, anti-inflammatory and analgesic agents

(2015) M.H. Helal et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Synthesis and biological evaluation of novel pyridine derivatives as potential anticancer agents and phosphodiesterase-3 inhibitors

(2014) Atieh Sadat Davari et al.   BIOORGANIC CHEMISTRY

Discovery of (E)-3-((Styrylsulfonyl)methyl)pyridine and (E)-2-((Styrylsulfonyl)methyl)pyridine Derivatives as Anticancer Agents: Synthesis, Structure–Activity Relationships, and Biological Activities

(2014) Tiangong Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

(2012) Christopher A. Lipinski et al.   ADVANCED DRUG DELIVERY REVIEWS

Urea Derivatives as Anticancer Agents

(2012) Huan-Qiu Li et al.   Anti-Cancer Agents in Medicinal Chemistry

BRN-103, a novel nicotinamide derivative, inhibits VEGF-induced angiogenesis and proliferation in human umbilical vein endothelial cells

(2011) Hye-Eun Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

SKLB610: A Novel Potential Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases Inhibits Angiogenesis and Tumor Growth in Vivo

(2011) Zhi-Xing Cao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

(2011) J. Jean Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phase 2 Trial of Linifanib (ABT-869) in Patients with Advanced Non-small Cell Lung Cancer

(2011) Eng-Huat Tan et al.   Journal of Thoracic Oncology