Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+depletion and the unfolded protein response

(2017) Pankaj Sehgal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours

(2016) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Discovery and Development of Topoisomerase Inhibitors as Anticancer Agents

(2016) Muthu K. Kathiravan et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Targeted Prodrug Approaches for Hormone Refractory Prostate Cancer

(2014) Herve Aloysius et al.   MEDICINAL RESEARCH REVIEWS

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

A Trojan Horse in Drug Development: Targeting of Thapsigargins Towards Prostate Cancer Cells

(2012) S. Christensen et al.   Anti-Cancer Agents in Medicinal Chemistry

Mitosis-Targeting Natural Products for Cancer Prevention and Therapy

(2012) Chinthalapally V. Rao et al.   CURRENT DRUG TARGETS

Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

(2012) S. R. Denmeade et al.   Science Translational Medicine

Impact of Natural Products on Developing New Anti-Cancer Agents†

(2009) Gordon M. Cragg et al.   CHEMICAL REVIEWS

Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells

(2009) D. J. Vander Griend et al.   MOLECULAR CANCER THERAPEUTICS

Cell adhesive hydrogels synthesised by copolymerisation of arg-protected Gly-Arg-Gly-Asp-Ser methacrylate monomers and enzymatic deprotection

(2008) Lynne Perlin et al.   CHEMICAL COMMUNICATIONS