Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands

Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study

(2016) Enza Lacivita et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Consensus Scoring Scheme for Selecting Class A Aminergic GPCR Fragments

(2016) Ádám A. Kelemen et al.   Journal of Chemical Information and Modeling

Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome

(2016) Yu Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Weighted Tanimoto Extreme Learning Machine with Case Study in Drug Discovery

(2015) Wojciech Marian Czarnecki   IEEE Computational Intelligence Magazine

Structure and function of serotonin G protein-coupled receptors

(2015) John D. McCorvy et al.   PHARMACOLOGY & THERAPEUTICS

5-HT2B Receptor Antagonists Inhibit Fibrosis and Protect from RV Heart Failure

(2015) Wiebke Janssen et al.   Biomed Research International

Multiple Fragment Docking and Linking in Primary and Secondary Pockets of Dopamine Receptors

(2014) Márton Vass et al.   ACS Medicinal Chemistry Letters

The Dynamic Process of β2-Adrenergic Receptor Activation

(2013) Rie Nygaard et al.   CELL

Predictive In Silico Studies of Human 5-hydroxytryptamine Receptor Subtype 2B (5-HT2B) and Valvular Heart Disease

(2013) Terry-Elinor Reid et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The ChEMBL bioactivity database: an update

(2013) A. Patrícia Bento et al.   NUCLEIC ACIDS RESEARCH

Structural Basis for Molecular Recognition at Serotonin Receptors

(2013) C. Wang et al.   SCIENCE

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

Serial Femtosecond Crystallography of G Protein-Coupled Receptors

(2013) W. Liu et al.   SCIENCE

Structure and dynamics of the M3 muscarinic acetylcholine receptor

(2012) Andrew C. Kruse et al.   NATURE

Pathway and mechanism of drug binding to G-protein-coupled receptors

(2011) Ron O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties

(2009) Neil Moss et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rhodopsin and the Others: A Historical Perspective on Structural Studies of G Protein-Coupled Receptors

(2009) Stefano Costanzi et al.   CURRENT PHARMACEUTICAL DESIGN

Chemical substructures that enrich for biological activity

(2008) Justin Klekota et al.   BIOINFORMATICS