Overcoming Aminoglycoside Enzymatic Resistance: Design of Novel Antibiotics and Inhibitors

Correlation of Aminoglycoside Consumption and Amikacin- or Gentamicin-Resistant Pseudomonas aeruginosa in Long-Term Nationwide Analysis: Is Antibiotic Cycling an Effective Policy for Reducing Antimicrobial Resistance?

(2018) Young Ah Kim et al.   Annals of Laboratory Medicine

Structure-Based Design and Synthesis of Apramycin–Paromomycin Analogues: Importance of the Configuration at the 6′-Position and Differences between the 6′-Amino and Hydroxy Series

(2017) Appi Reddy Mandhapati et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of solvent and protein dynamics in ligand recognition and inhibition of aminoglycoside adenyltransferase 2″-Ia

(2017) Valjean R. Bacot-Davis et al.   PROTEIN SCIENCE

Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design

(2016) Angelia V. Bassenden et al.   ACS Chemical Biology

Genomics and the evolution of antibiotic resistance

(2016) Michael R. Gillings et al.   Annals of the New York Academy of Sciences

Plazomicin is effective in a non-human primate pneumonic plague model

(2016) William M. Mega et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis

(2016) Atefeh Garzan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation

(2016) Ido M. Herzog et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective modification of the 3′′-amino group of kanamycin prevents significant loss of activity in resistant bacterial strains

(2016) Andrés G. Santana et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

6-O-Nucleotidyltransferase: an aminoglycoside-modifying enzyme specific for streptomycin/streptidine

(2016) Montserrat Latorre et al.   MedChemComm

Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″)-Ia

(2015) Georgina Cox et al.   mBio

Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3′′)(9) adenyltransferase

(2015) Yang Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Inhibition of the ANT(2″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones

(2014) Danielle R. Hirsch et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Singly Modified Amikacin and Tobramycin Derivatives Show Increased rRNA A-Site Binding and Higher Potency against Resistant Bacteria

(2014) Richard J. Fair et al.   ChemMedChem

Design, synthesis, and evaluation of novel fluoroquinolone–flavonoid hybrids as potent antibiotics against drug-resistant microorganisms

(2014) Zhu-Ping Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial susceptibility and resistance mechanisms of methicillin resistant Staphylococcus aureusisolated from 12 Hospitals in Turkey

(2014) Ömer Yıldız et al.   Annals of Clinical Microbiology and Antimicrobials

Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections

(2013) Kristin J Labby et al.   Future Medicinal Chemistry

Synthesis and Evaluation of Hetero- and Homodimers of Ribosome-Targeting Antibiotics: Antimicrobial Activity, in Vitro Inhibition of Translation, and Drug Resistance

(2013) Yifat Berkov-Zrihen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand promiscuity through the eyes of the aminoglycosideN3 acetyltransferase IIa

(2013) Adrianne L. Norris et al.   PROTEIN SCIENCE

Multiple Keys for a Single Lock: The Unusual Structural Plasticity of the Nucleotidyltransferase (4′)/Kanamycin Complex

(2012) Ruth Matesanz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selectively Guanidinylated Aminoglycosides as Antibiotics

(2012) Richard J. Fair et al.   ChemMedChem

Development of Aminoglycoside Antibiotics Effective Against Resistant Bacterial Strains

(2012) Lin Yang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Fourteen years in resistance

(2012) David M. Livermore   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Activity of Plazomicin (ACHN-490) against MDR clinical isolates ofKlebsiella pneumoniae, Escherichia coli, andEnterobacterspp. from Athens, Greece

(2012) Irene Galani et al.   JOURNAL OF CHEMOTHERAPY

Increased Structural Flexibility at the Active Site of a Fluorophore-conjugated β-Lactamase Distinctively Impacts Its Binding toward Diverse Cephalosporin Antibiotics

(2011) Wai-Ting Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of 6′- and 6′′′-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance

(2011) Pazit Shaul et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An Efficient and General Route to the Synthesis of Novel Aminoglycosides for RNA Binding

(2011) Julia Revuelta et al.   SYNLETT

Rational design and synthesis of potent aminoglycoside antibiotics against resistant bacterial strains

(2010) Ri-Bai Yan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-Based Design of Highly Crowded Ribostamycin/Kanamycin Hybrids as a New Family of Antibiotics

(2010) Julia Revuelta et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Unusual Nucleotide Recognition Properties of the Resistance Enzyme ANT(4′): Inorganic Tri/Polyphosphate as a Substrate for Aminoglycoside Inactivation

(2010) Julia Revuelta et al.   CHEMISTRY-A EUROPEAN JOURNAL

Aminoglycoside modifying enzymes

(2010) Maria S. Ramirez et al.   DRUG RESISTANCE UPDATES

Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance

(2010) Varvara Pokrovskaya et al.   Expert Opinion on Drug Discovery

Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates

(2010) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Role of Aromatic Rings in the Molecular Recognition of Aminoglycoside Antibiotics: Implications for Drug Design

(2010) Tatiana Vacas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge

(2009) Cesar A. Arias et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selective deprotection of the Cbz amine protecting group for the facile synthesis of kanamycin A dimers linked at N-3″ position

(2009) Gui-Hui Chen et al.   TETRAHEDRON

Regioselective modification of amino groups in aminoglycosides based on cyclic carbamate formation

(2008) Guihui Chen et al.   TETRAHEDRON