Article
Pharmacology & Pharmacy
Yan Huang, Gang Wang, Zhan Zhou, Zhengshan Tang, Ningning Zhang, Xiaoyan Zhu, Xin Ni
Summary: The gasotransmitter H2S plays a crucial role in maintaining normal oxygen saturation in the lungs and preventing lung injury, inflammation, and oxidative stress. GYY4137 treatment was effective in ameliorating these conditions in both genetic deficiency and hypoxia-induced mouse models.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Qian Lin, Bin Geng
Summary: This article discusses the significant impact of atherosclerosis on cardiovascular events and global mortality, as well as the role of hydrogen sulfide in plaque stability and its regulation mechanism on different cell populations.
Article
Agriculture, Dairy & Animal Science
Bohao Zhang, Ting Lin, Xu Bai, Xiaoxiao An, Lijun Dai, Jun Shi, Yong Zhang, Xingxu Zhao, Quanwei Zhang
Summary: This study identified differentially expressed proteins (DEPs) associated with hydrogen sulfide metabolism in Holstein cows with clinical mastitis (CM), indicating the important role of cystathionine-gamma-lyase (CTH)/H2S in CM. The findings provide insight into the function and regulatory mechanism of CTH/H2S in Holstein cows and can contribute to the prevention and treatment of CM.
Review
Pharmacology & Pharmacy
Sunil Jamuna Tripathi, Suwarna Chakraborty, Emiko Miller, Andrew A. Pieper, Bindu D. Paul
Summary: The gaseous neurotransmitter hydrogen sulfide (H2S) exerts neuroprotective effects in the brain through post-translational modification of cysteine residues by sulfhydration. It cannot be stored in vesicles due to its gaseous nature and is either synthesized or released from endogenous stores. Sulfhydration has both specific and general neuroprotective effects and is diminished in neurodegenerative disorders, while excessive cellular H2S is linked to certain forms of neurodegenerative disease. This review explores the role of H2S in signaling across various neurodegenerative diseases and age-related neurodegeneration.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Multidisciplinary Sciences
Heng Zhang, Yaqian Huang, Selena Chen, Chaoshu Tang, Guang Wang, Junbao Du, Hongfang Jin
Summary: H2S plays a crucial role in glucose metabolism by affecting insulin secretion, apoptosis of islet β cells, insulin sensitivity, glucose uptake, adipogenesis, lipolysis, and modulation of circadian-clock genes. Further studies are needed to determine whether H2S could be a promising target for diabetes mellitus treatment.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Laura Micheli, Emma Mitidieri, Carlotta Turnaturi, Domenico Vanacore, Clara Ciampi, Elena Lucarini, Giuseppe Cirino, Carla Ghelardini, Raffaella Sorrentino, Lorenzo Di Cesare Mannelli, Roberta D'Emmanuele di Villa Bianca
Summary: In an in vitro model of sarcopenia, impairment in CBS/CSE/H2S signaling occurs, and glucoraphanin, as a natural H2S-releasing molecule, appears to be more effective in preventing muscle damage. Therefore, glucoraphanin supplementation could be an innovative therapeutic approach in the management of sarcopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yaping Niu, Congkuo Du, Changting Cui, Haizeng Zhang, Yue Deng, Jun Cai, Zhenzhen Chen, Bin Geng
Summary: The study identified NW as a novel CSE agonist that enhances CSE generation of H2S, thereby alleviating kidney I/R injury and hypertension. NW shows potential therapeutic merit for cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dalila G. F. Fernandes, Joao Nunes, Catarina S. Tome, Karim Zuhra, Joao M. F. Costa, Alexandra M. M. Antunes, Alessandro Giuffre, Joao B. Vicente
Summary: Gasotransmitters hydrogen sulfide, nitric oxide, and carbon monoxide play critical roles in human physiology by mediating signal transduction through interaction with protein targets. Research shows that S-nitrosation can inhibit hydrogen sulfide production through affecting various protein cysteine residues, highlighting a new mechanism of crosstalk between gasotransmitters.
Article
Biochemistry & Molecular Biology
Sumeet Manandhar, Stephen Chambers, Andrew Miller, Isao Ishii, Madhav Bhatia
Summary: This study investigates the effect of hydrogen sulfide (H2S) on adhesion molecules in endothelial cells of vital organs in mice with sepsis. The researchers found that H2S reduced adhesion molecule expression and liver and lung injury in septic mice. They also validated the use of PAG as a tool to study the Cth/H2S-signaling axis in sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jun Wang, Guanya Jia, Heng Li, Shasha Yan, Jing Qian, Xin Guo, Ge Li, Haizhen Qi, Zhilong Zhu, Yanjun Wu, Weijuan He, Weining Niu
Summary: Oxidation induces the formation of a disulfide bond within the CSE protein, enhancing its H2S-producing activity and promoting cellular H2S production under oxidative stress conditions. The residue Cys255 plays a crucial role in sensing oxidation and forming a disulfide bond with Cys252.
Article
Biochemistry & Molecular Biology
Gopi K. Kolluru, John D. Glawe, Sibile Pardue, Ahmad Kasabali, Shafiul Alam, Saranya Rajendran, Allison L. Cannon, Chowdhury S. Abdullah, James G. Traylor, Rodney E. Shackelford, Matthew D. Woolard, A. Wayne Orr, Nicholas E. Goeders, Paari Dominic, Md Shenuarin S. Bhuiyan, Christopher G. Kevil
Summary: Methamphetamine use has been found to significantly decrease cardiovascular function by reducing the availability of cystathionine gamma lyase (CSE), hydrogen sulfide (H2S), and nitric oxide (NO). This leads to endothelial dysfunction and pathological changes in the heart. Increasing CSE/H2S bioavailability may be a potential therapeutic intervention for attenuating METH-induced cardiovascular disease.
Article
Biochemistry & Molecular Biology
Shuang Zhao, Celine Deslarzes-Dubuis, Severine Urfer, Martine Lambelet, Sebastien Deglise, Florent Allagnat
Summary: This study investigated the expression and regulation of CSE, CBS, and 3-MST enzymes in human saphenous vein and large arteries. The results showed that CSE was negatively regulated by arterial shear stress and inhibited human vascular smooth muscle cell migration.
Article
Nutrition & Dietetics
Jiaxiang Duan, Lunli Xiang, Zhen Yang, Li Chen, Jianteng Gu, Kaizhi Lu, Daqing Ma, Hailin Zhao, Bin Yi, Hongwen Zhao, Jiaolin Ning
Summary: This study found that methionine restriction (MR) can attenuate lipopolysaccharide (LPS)-induced lung injury by regulating cystathionine-gamma-lyase (CSE) expression and hydrogen sulfide (H2S). MR inhibits the activation of TLR4/NF-kappa B/NOD-like receptor protein 3 (NLRP3) pathway, reducing the release of inflammatory mediators and immune cell infiltration.
Article
Biochemistry & Molecular Biology
Yingying Wang, Xiang Ni, Rahuljeet Chadha, Caitlin McCartney, Yannie Lam, Brock Brummett, Geat Ramush, Ming Xian
Summary: Hydrogen sulfide (H2S) plays critical roles in redox biology, and its imbalance can lead to pathological processes. Recent advances in inhibitors and scavengers for H2S have been made, but challenges remain, including potency and specificity of inhibitors, as well as biologically active by-products produced during scavenging. Further development is needed for potent and specific inhibitors, as well as scavengers that generate biocompatible by-products for potential therapeutic applications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Chenghua Luo, Dengyu Ji, Yan Li, Yan Cao, Shangyue Zhang, Wenjing Yan, Ke Xue, Jiayin Chai, Ye Wu, Huirong Liu, Wen Wang
Summary: This study revealed a new mechanism of post-translational modification of Sp1/CSE, investigated the specific effects of homocysteine metabolism disorder on H2S deficiency, and proposed therapeutic strategies involving restoring S-sulfhydration and blocking nitration.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Psychiatry
Jing Mao, Tianmei Li, Di Fan, Hongli Zhou, Jianguo Feng, Li Liu, Chunxiang Zhang, Xiaobin Wang
Article
Cardiac & Cardiovascular Systems
Ziying Chen, Flora Gordillo-Martinez, Lei Jiang, Pengcheng He, Wanzi Hong, Xuebiao Wei, Katherine A. Staines, Vicky E. Macrae, Chunxiang Zhang, Danqing Yu, Xiaodong Fu, Dongxing Zhu
Summary: The study suggests that zinc may act as a novel inhibitor of CAVD by regulating GPR39-dependent ERK1/2 signaling pathway to inhibit cell calcification, and zinc transporter ZIP13 and ZIP14 play important roles in regulating cell calcification and osteogenic differentiation. Zinc supplementation could be a potential therapeutic strategy for CAVD.
CARDIOVASCULAR RESEARCH
(2021)
Article
Medicine, Research & Experimental
Guangqi Liu, Dan Yan, Liu Yang, Yunwei Sun, Lin Zhan, Lili Lu, Zhigang Jin, Chunxiang Zhang, Ping Long, Jinhua Chen, Qiong Yuan
Summary: The research revealed that in patients with DCM, there is an increase in M1 macrophage infiltration in the heart tissue, while M2 macrophages decrease. Through investigating the role of the miR-471-3p/SIRT1 pathway, it was found that miR-471-3p negatively regulates SIRT1 expression, promoting macrophage inflammatory polarization.
Article
Plant Sciences
Chaoyun Wang, Hongzhi Wan, Miao Li, Chunxiang Zhang
Summary: Celastrol improves memory dysfunction induced by ischemia/reperfusion (I/R) through regulating the AK005401/MAP3K12 signaling pathway, enhancing antioxidant capacity, reducing cell apoptosis, and improving mitochondrial function. Celastrol has the potential to prevent neuronal injury induced by I/R.
Article
Multidisciplinary Sciences
Aijun Qiao, Junlan Zhou, Shiyue Xu, Wenxia Ma, Chan Boriboun, Teayoun Kim, Baolong Yan, Jianxin Deng, Liu Yang, Eric Zhang, Yuhua Song, Yongchao C. Ma, Stephane Richard, Chunxiang Zhang, Hongyu Qiu, Kirk M. Habegger, Jianyi Zhang, Gangjian Qin
Summary: The RNA-binding adaptor protein Sam68 promotes hepatic gluconeogenesis by stabilizing the transcriptional coactivator CRTC2, leading to increased blood glucose levels. Deletion of Sam68 alleviates hyperglycemia, suggesting it as a potential therapeutic target for diabetes.
NATURE COMMUNICATIONS
(2021)
Article
Physiology
Huiya Huang, Linlin Wang, Fanyu Qian, Xiong Chen, Haiping Zhu, Mei Yang, Chunxiang Zhang, Maoping Chu, Xiaorong Wang, Xiaozhong Huang
Summary: Lira has a significant inhibitory effect on hyperglycemia-induced endothelial dysfunction and angiogenesis disturbance, promoting diabetic wound healing by restoring impaired AMPK signaling pathway activity. The protective and pro-angiogenic effects of Lira are regulated by AMPK, with the promotion of diabetic wound healing dependent on the Hif-1 alpha-HO-1 axis.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Ming Jia, Dan Zhang, Chunxiang Zhang, Chunhong Li
Summary: Modulating the microenvironment of pancreatic cancer is considered a promising therapeutic approach, and nano-delivery systems have been developed to alter the TME. These systems change the microenvironment in various ways, including depleting ECM, inhibiting CAFs, reversing immunosuppression, promoting angiogenesis, and improving the hypoxic environment.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yuliang Feng, Liuyang Cai, Wanzi Hong, Chunxiang Zhang, Ning Tan, Mingyang Wang, Cheng Wang, Feng Liu, Xiaohong Wang, Jianyong Ma, Chen Gao, Mohit Kumar, Yuanxi Mo, Qingshan Geng, Changjun Luo, Yan Lin, Haiyang Chen, Shuang-Yin Wang, Michael J. Watson, Anil G. Jegga, Roger A. Pedersen, Ji-Dong Fu, Zhao Wang, Guo-Chang Fan, Sakthivel Sadayappan, Yigang Wang, Siim Pauklin, Feng Huang, Wei Huang, Lei Jiang
Summary: This study investigates the role of 3-dimensional chromatin topology in dilated cardiomyopathy (DCM) by analyzing the epigenome and transcriptome maps of DCM and nonfailing heart tissues. The research reveals that the reprogramming of chromatin topology is associated with transcriptional dysregulation in DCM, with the key transcription factor HAND1 implicated in the process. The findings provide insights into the pathogenesis of DCM and highlight the importance of chromatin organization in heart failure.
Article
Cardiac & Cardiovascular Systems
Huan Yu, Weiyue Sun, Haoran Wu, Shuchi Zhang, Zhipeng Xu, Rongzhou Wu, Xing Rong, Huixian Qiu, Jinshun Zhu, Chunxiang Zhang, Maoping Chu
Summary: This study aimed to investigate the impact of Kawasaki disease-related factors on the development of coronary artery aneurysms (CAA). The results showed that the absence of rash, oral changes, and cervical lymphadenopathy are risk factors for CAA, especially in female patients. Accurate recognition of symptoms, early diagnosis, and standard treatment are crucial in reducing the incidence of CAA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Runyu Liu, Junbing Pan, Chunxiang Zhang, Xiaolei Sun
Summary: Vaccination against COVID-19 has become crucial in controlling the pandemic, but it comes with potential cardiovascular complications such as myocarditis and immune thrombocytopenia. Accurate reporting and monitoring of vaccine safety are essential to address public concerns and ensure effective vaccine administration.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Yeying Sun, Rongrong Liu, Xiangwen Xia, Luchuan Xing, Jing Jiang, Weihua Bian, Wendy Zhang, Chunhua Wang, Chunxiang Zhang
Summary: This study determined the expression profiles of lncRNAs in human platelets and found that aberrantly expressed lncRNAs might be related to platelet activity and other functions. A clinical study showed that a down-regulated lncRNA in hyperreactive platelets was also significantly decreased in platelets from patients with acute myocardial infarction, which could be partially reversed by aspirin treatment.
Article
Cardiac & Cardiovascular Systems
Qian Ma, Qiuhua Yang, Jiean Xu, Xiaoyu Zhang, David Kim, Zhiping Liu, Qingen Da, Xiaoxiao Mao, Yaqi Zhou, Yongfeng Cai, Vidhi Pareek, Ha Won Kim, Guangyu Wu, Zheng Dong, Wen-Liang Song, Lin Gan, Chunxiang Zhang, Mei Hong, Stephen J. Benkovic, Neal L. Weintraub, David Fulton, John M. Asara, Issam Ben-Sahra, Yuqing Huo
Summary: This study reveals the important role of de novo purine synthesis in VSMC proliferation in arterial disease and suggests that targeting ATIC could be a promising therapeutic approach.
Review
Oncology
Xiaoran Guan, Yeying Sun, Chunxiang Zhang
Summary: Long non-coding RNA (LncRNA) is a class of non-coding RNA with more than 200 nucleotides, widely involved in biological processes and associated with the occurrence and development of various diseases. Studies have revealed the crucial role of LncRNA in red blood cell development and the pathogenesis of hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Gan Qiao, Jinshan Xing, Xin Luo, Chunxiang Zhang, Jingyan Yi
Summary: In this study, new biomarkers and potential therapeutic targets for polycystic ovary syndrome (PCOS) were explored using integrated bioinformatics tools. The key gene GNB3 was identified as the most important regulatory gene in PCOS, and a compound (compound 1) was found to interact with GNB3 and affect its function. The results suggest that compound 1 could be considered as a lead compound for drug development. This study provides new insights into PCOS-related drug development.
Article
Biochemistry & Molecular Biology
Jialing Shen, Ming Zhao, Chunxiang Zhang, Xiaolei Sun
Summary: Atherosclerotic vascular calcification is associated with increased risk of death in patients with cardiovascular diseases. IL-1 beta plays diverse roles in the pathogenesis of this condition, and anti-IL-1 beta therapy has shown to reduce the incidence of cardiovascular events, though the underlying mechanism remains unclear. This review summarizes current knowledge and clinical trial results on the role of IL-1 beta in atherosclerotic vascular calcification.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
