A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling
Authors
Keywords
-
Journal
MOLECULAR PSYCHIATRY
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2018-06-18
DOI
10.1038/s41380-018-0101-x
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1
- (2017) Tetsuo Cai et al. JOURNAL OF NEUROSCIENCE
- BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis
- (2017) Shuting Zhang et al. JOURNAL OF NEUROSCIENCE
- Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase
- (2016) Linfeng Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis
- (2013) Yu Deng et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- Biological function of Presenilin and its role in AD pathogenesis
- (2013) Shuting Zhang et al. Translational Neurodegeneration
- The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
- (2012) Lucía Chávez-Gutiérrez et al. EMBO JOURNAL
- Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes
- (2012) Philip T.T. Ly et al. JOURNAL OF CLINICAL INVESTIGATION
- Structure of a presenilin family intramembrane aspartate protease
- (2012) Xiaochun Li et al. NATURE
- Effect of Synthetic Cannabinoid HU210 on Memory Deficits and Neuropathology in Alzheimers Disease Mouse Model
- (2010) B. Chen et al. Current Alzheimer Research
- Functional Analysis of the Transmembrane Domains of Presenilin 1
- (2010) Naoto Watanabe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Participation of Transmembrane Domain 1 of Presenilin 1 in the Catalytic Pore Structure of the -Secretase
- (2010) S. Takagi et al. JOURNAL OF NEUROSCIENCE
- Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease
- (2010) Gen He et al. NATURE
- A novel presenilin 1 mutation (Ser169del) in a Chinese family with early-onset Alzheimer's disease
- (2009) Jifeng Guo et al. NEUROSCIENCE LETTERS
- Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models
- (2008) Hong Qing et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the -Secretase
- (2008) C. Sato et al. JOURNAL OF NEUROSCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started