Article
Microbiology
Victoria Palma, Maria Soledad Gutierrez, Orlando Vargas, Raghuveer Parthasarathy, Paola Navarrete
Summary: Bacterial motility is a common characteristic that can be studied through various methods, with three-dimensional imaging being advantageous in microscopic approaches. Understanding bacterial motility is also important for studying bacterial-host interactions.
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: The liver is a non-immunological organ involved in metabolic activities, nutrient storage, and detoxification. Resident immune cells in the liver drive immunological reactions and certain microRNAs are associated with the immune response to pathogens, although the exact mechanism of miRNA interference in these interactions remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Microbiology
Vera Vozandychova, Pavla Stojkova, Kamil Hercik, Pavel Rehulka, Jiri Stulik
Summary: Ubiquitination, similar to phosphorylation and acetylation, plays a crucial role in regulating various cell processes. Understanding how pathogens manipulate host ubiquitination processes is important for vaccine development and disease treatment. Pathogenic bacteria encode effector proteins targeting the host ubiquitin machinery to disrupt host defense processes.
Review
Biochemistry & Molecular Biology
Eleanor K. P. Marshall, Marc S. Dionne
Summary: Fruit fly Drosophila melanogaster has emerged as an important model for studying host-pathogen interactions, particularly in the context of mycobacterial infections. Studies using Drosophila have identified key factors involved in controlling or resisting mycobacterial infections, laying the groundwork for further research into the interaction between host and pathogen factors. The development of genetic tools for manipulating mycobacterial genomes holds promise for more detailed investigations using the fruit fly model, although its full potential has yet to be fully realized.
MOLECULAR MICROBIOLOGY
(2022)
Article
Immunology
Suborno Jati, Soham Sengupta, Malini Sen
Summary: The study found that the Wnt5A signaling pathway plays different roles in handling pathogenic and non-pathogenic infections, with a potentially crucial role in regulating intracellular actin organization of bacteria.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Fitz Gerald S. Silao, Per O. Ljungdahl
Summary: Nutrient uptake and metabolism, especially amino acid uptake, play vital roles in the virulence of Candida albicans, a pathogenic fungus closely associated with human hosts.
Review
Cell Biology
Dominik Brokatzky, Serge Mostowy
Summary: Pyroptosis is a regulated form of cell death characterized by cell lysis and the release of pro-inflammatory molecules. It plays a crucial role in bacterial infection by promoting an inflammatory response and eliminating intracellular pathogens. Recent studies using various bacterial pathogens have enhanced our understanding of pyroptosis and its importance in host defense.
DISEASE MODELS & MECHANISMS
(2022)
Article
Microbiology
Mark Deehan, Weiwei Lin, Benjamin Blum, Andrew Emili, Horacio Frydman
Summary: Autophagy is an intracellular degradation pathway involved in innate immunity. Pathogenic bacteria have evolved several mechanisms to escape degradation or exploit autophagy to acquire host nutrients. In the case of endosymbionts, which often have commensal or mutualistic interactions with the host, autophagy is not well characterized. We utilized tissue-specific autophagy mutants to determine if Wolbachia, a vertically transmitted obligate endosymbiont of Drosophila melanogaster, is regulated by autophagy in somatic and germ line cell types. Our analysis revealed core autophagy proteins Atg1 and Atg8 and a selective autophagy-specific protein Ref(2)p negatively regulate Wolbachia in the hub, a male gonad somatic cell type. Furthermore, we determined that the Wolbachia effector protein, CifB, modulates autophagy-Wolbachia interactions, identifying a new host-related pathway which these bacterial proteins interact with. In the female germ line, the cell type necessary for inheritance of Wolbachia through vertical transmission, we discovered that bulk autophagy mediated by Atg1 and Atg8 positively regulates Wolbachia density, whereas Ref(2)p had no effect. Global metabolomics of fly ovaries deficient in germ line autophagy revealed reduced lipid and carbon metabolism, implicating metabolites from these pathways as positive regulators of Wolbachia. Our work provides further understanding of how autophagy affects bacteria in a cell type-dependent manner. Autophagy is a eukaryotic intracellular degradation pathway which can act as an innate immune response to eliminate pathogens. Conversely, pathogens can evolve proteins which modulate the autophagy pathway to subvert degradation and establish an infection. Wolbachia, a vertically transmitted obligate endosymbiont which infects up to 40% of insect species, is negatively regulated by autophagy in whole animals, but the specific molecular mechanism and tissue which govern this interaction remain unknown. Our studies use cell type-specific autophagy mutants to reveal that Wolbachia is negatively regulated by selective autophagy in the soma, while nonselective autophagy positively regulates Wolbachia in the female germ line. These data provide evidence that cell type can drive different basal autophagy programs which modulate intracellular microbes differently. Additionally, we identified that the Wolbachia effector CifB acts in the selective autophagy pathway to aid in intracellular bacterial survival, providing a new function for CifB beyond its previously identified role in reproductive manipulation.
Review
Biotechnology & Applied Microbiology
Paula M. Tribelli, Nancy Lopez
Summary: This review provides an overview of temperature-response mechanisms in Pseudomonas species and highlights their relevance to human and animal health as well as agricultural applications.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Immunology
Yibin Yang, Xia Zhu, Haixin Zhang, Yuhua Chen, Yi Song, Xiaohui Ai
Summary: The study on the host-pathogen interaction between channel catfish and Yersinia ruckeri revealed the dynamic regulation of the transcriptome during infection, with significant upregulation of immune-related pathways. Specifically, the infection was found to be closely related to metabolic pathways, and the pathogenesis promoted by Y. ruckeri in channel catfish was mainly through the flagellum gene fliC. This research contributes to understanding how catfish respond to infection and develop enteric red mouth disease (ERM) through a transcriptional perspective.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Jingjing Luo, Lidong Wang, Lei Song, Zhao-Qing Luo
Summary: Ubiquitination is a commonly used post-translational modification in eukaryotic cells that plays a crucial role in immune responses. Pathogens like Legionella pneumophila utilize ubiquitin signaling to modulate host cell processes, support replication, and manipulate ubiquitin signaling through effector proteins.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Cell Biology
Johannes Westman, Sergio Grinstein
Summary: The ability of phagosomes to halt microbial growth is closely linked to their ability to acidify their luminal pH, but certain pathogens can survive and replicate inside phagosomes by targeting the pH-regulatory machinery of host cells to survive or escape.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Daniel Hammers, Katelyn Carothers, Shaun Lee
Summary: Bacterial secreted proteases play a crucial role in modulating the extracellular environment and interacting with other species. They have significant impacts on the immune system and microbial competition. Understanding how these proteases regulate host protection mechanisms and contribute to antimicrobial and anti-biofilm dynamics is of great importance for human health.
CURRENT DRUG TARGETS
(2022)
Review
Biochemistry & Molecular Biology
Kara R. Eichelberger, Saikat Paul, Brian M. Peters, James E. Cassat
Summary: This review highlights the impact of Candida albicans-bacteria interactions on healthy polymicrobial community structure, host immune responses, and microbial pathogenesis, and discusses the significance of these interactions in discovering novel antivirulence compounds for fungal infections.
TRENDS IN MICROBIOLOGY
(2023)
Review
Plant Sciences
Riccardo Lorrai, Simone Ferrari
Summary: The plant cell wall is a complex structure that can restrict most microbes’ access. Plants have evolved proteins to inhibit CWDEs, reducing cell wall damage and triggering an immune response. This interaction between CWI surveillance system and the innate immune system helps strike a balance between defense and growth.
Article
Biochemistry & Molecular Biology
Ying-Tao Zhao, Meng Wang, Zhi-Min Wang, Rong-Xiang Fang, Xiu-Jie Wang, Yan-Tao Jia
JOURNAL OF GENETICS AND GENOMICS
(2015)
Article
Multidisciplinary Sciences
Chunxi Yang, Chaoyu Cui, Qiumian Ye, Jinhong Kan, Shuna Fu, Shihao Song, Yutong Huang, Fei He, Lian-Hui Zhang, Yantao Jia, Yong-Gui Gao, Caroline S. Harwood, Yinyue Deng
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Review
Biology
Jinhong Kan, Rongxiang Fang, Yantao Jia
SCIENCE CHINA-LIFE SCIENCES
(2017)
Article
Biotechnology & Applied Microbiology
Jingxi Zhang, Jinhong Kan, Jieqiong Zhang, Ping Guo, Xiaoying Chen, Rongxiang Fang, Yantao Jia
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2012)
Article
Biotechnology & Applied Microbiology
Hong Liang, Ying-Tao Zhao, Jie-Qiong Zhang, Xiu-Jie Wang, Rong-Xiang Fang, Yan-Tao Jia
Article
Cell Biology
Li Wang, Lili Zhang, Yunfeng Geng, Wei Xi, Rongxiang Fang, Yantao Jia
Article
Biochemistry & Molecular Biology
Chunyan Zhang, Mingfa Lv, Wenfang Yin, Tingyan Dong, Changqing Chang, Yansong Miao, Yantao Jia, Yinyue Deng
MOLECULAR PLANT-MICROBE INTERACTIONS
(2019)
Article
Biotechnology & Applied Microbiology
Yanmei Li, Zhongkai Zhang, Yantao Jia, Yuemao Shen, Hongping He, Rongxiang Fang, Xiaoying Chen, Xiaojiang Hao
PLANT BIOTECHNOLOGY JOURNAL
(2008)
Article
Microbiology
Kun Li, Yanan Zhu, Wei Yan, Xin Deng, Yanmei Xiao, Liyang Song, Rongxiang Fang, Yantao Jia, Xiaoyan Tang
Article
Plant Sciences
Lin An, Siyuan Zhang, Ping Guo, Liyang Song, Chuanmiao Xie, Hongyan Guo, Rongxiang Fang, Yantao Jia
Summary: The research identified a gene in rice, RIR1, which acts as a repressor in the resistance against Xoo infection, with its overexpression making rice more susceptible to the pathogen. It was found that pathogens may inhibit OsmiR159 to interfere with the RIR1-NUO interaction, leading to the suppression of rice immune signaling pathways during host-pathogen interactions.
MOLECULAR PLANT PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lili Zhang, Yantao Jia, Li Wang, Rongxiang Fang
MOLECULAR MICROBIOLOGY
(2007)
Article
Biochemistry & Molecular Biology
W Qian, YT Jia, SX Ren, YQ He, JX Feng, LF Lu, QH Sun, G Ying, DJ Tang, H Tang, W Wu, P Hao, LF Wang, BL Jiang, SY Zeng, WY Gu, G Lu, L Rong, YC Tian, ZJ Yao, G Fu, BS Chen, RX Fang, BQ Qiang, Z Chen, GP Zhao, JL Tang, CZ He