Isothiocyanates and Xenobiotic Detoxification

Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress

(2017) Emiko Yoda et al.   Scientific Reports

Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers

(2016) J.-M. Yuan et al.   Cancer Prevention Research

2-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke

(2016) J.-M. Yuan et al.   Cancer Prevention Research

4-Methylthio-3-butenyl isothiocyanate (raphasatin) exerts chemopreventive effects against esophageal carcinogenesis in rats

(2016) Isamu Suzuki et al.   Journal of Toxicologic Pathology

Bioavailability and in vivo metabolism of intact glucosinolates

(2016) Jens Christian Sørensen et al.   Journal of Functional Foods

Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens

(2016) Romain Duval et al.   Oncotarget

Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats

(2015) Thangarasu Rajakumar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A principal mechanism for the cancer chemopreventive activity of phenethyl isothiocyanate is modulation of carcinogen metabolism

(2015) Costas Ioannides et al.   DRUG METABOLISM REVIEWS

Glucosinolates Are Mainly Absorbed Intact in Germfree and Human Microbiota-Associated Mice

(2015) Julia Budnowski et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bioavailability and metabolism of benzyl glucosinolate in humans consuming Indian cress (Tropaeolum majusL.)

(2015) Stefanie Platz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dietary Doses of Sulforaphane Affect Hepatic Drug Metabolizing Enzymes in Spontaneously Hypertensive Rats

(2015) Anik Amin et al.   PHYTOTHERAPY RESEARCH

Effects of sulforaphane and its S- and R-enantiomers on the expression and activities of human drug-metabolizing cytochromes P450

(2015) Alzbeta Srovnalova et al.   Journal of Functional Foods

Pharmacokinetics, Tissue Distribution, and Anti-Lipogenic/Adipogenic Effects of Allyl-Isothiocyanate Metabolites

(2015) Yang-Ji Kim et al.   PLoS One

Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China

(2014) P. A. Egner et al.   Cancer Prevention Research

Molecular targets of isothiocyanates in cancer: Recent advances

(2014) Parul Gupta et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Genetic regulation of glucoraphanin accumulation in Beneforté®broccoli

(2013) Maria H Traka et al.   NEW PHYTOLOGIST

Analysis of 4-Hydroxy-1-(3-pyridyl)-1-butanone (HPB)-Releasing DNA Adducts in Human Exfoliated Oral Mucosa Cells by Liquid Chromatography–Electrospray Ionization–Tandem Mass Spectrometry

(2012) Irina Stepanov et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A glucosinolate-rich extract of Japanese Daikon perturbs carcinogen-metabolizing enzyme systems in rat, being a potent inducer of hepatic glutathione S-transferase

(2012) Ahmad Faizal Abdull Razis et al.   EUROPEAN JOURNAL OF NUTRITION

Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes

(2012) M. La Marca et al.   FOOD AND CHEMICAL TOXICOLOGY

Characterization of the Temporal Induction of Hepatic Xenobiotic-Metabolizing Enzymes by Glucosinolates and Isothiocyanates: Requirement for at Least a 6 h Exposure To Elicit Complete Induction Profile

(2012) Ahmad F. Abdull Razis et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices

(2012) Costas Ioannides   XENOBIOTICA

4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent

(2011) Ahmed Faizal Abdull Razis et al.   ARCHIVES OF TOXICOLOGY

Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China

(2011) P. A. Egner et al.   Cancer Prevention Research

Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China

(2011) Thomas W. Kensler et al.   CARCINOGENESIS

Exposure to Isothiocyanates Suppresses Urinary Mutagenicity in Rats Treated With Heterocyclic Amine IQ: Lack of Association With CYP1 Activity

(2011) Natalya Hanlon et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450

(2010) Nattaya Konsue et al.   ARCHIVES OF TOXICOLOGY

Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality

(2010) Ahmad Faizal Abdull Razis et al.   ARCHIVES OF TOXICOLOGY

Formation and Distribution of NNK Metabolites in an Isolated Perfused Rat Lung

(2010) L. A. Maertens et al.   DRUG METABOLISM AND DISPOSITION

The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer

(2010) Ahmad Faizal Abdull Razis et al.   INTERNATIONAL JOURNAL OF CANCER

Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin

(2010) Ahmad Faizal Abdull Razis et al.   LUNG CANCER

Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate

(2010) Nattaya Konsue et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Sulforaphane- and Phenethyl Isothiocyanate–Induced Inhibition of Aflatoxin B1–Mediated Genotoxicity in Human Hepatocytes: Role of GSTM1 Genotype and CYP3A4 Gene Expression

(2010) Kerstin Gross-Steinmeyer et al.   TOXICOLOGICAL SCIENCES

Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables

(2010) Ahmad F. Abdull Razis et al.   TOXICOLOGY

Urinary Isothiocyanates; Glutathione S-Transferase M1, T1, and P1 Polymorphisms; and Risk of Colorectal Cancer: The Multiethnic Cohort Study

(2009) M. Epplein et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Cruciferous Vegetable Consumption and Lung Cancer Risk: A Systematic Review

(2009) T. K. Lam et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers

(2009) Natalya Hanlon et al.   CANCER LETTERS

Dietary glucosinolate intake and risk of prostate cancer in the EPIC-Heidelberg cohort study

(2009) Astrid Steinbrecher et al.   INTERNATIONAL JOURNAL OF CANCER

The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD(P)H:quinone oxidoreductase (NQO1) in human liver compared with rat

(2009) Natalya Hanlon et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats

(2009) Nattaya Konsue et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables

(2009) Nattaya Konsue et al.   TOXICOLOGY

Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane

(2008) Natalya Hanlon et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate

(2008) N. Konsue et al.   FOOD AND CHEMICAL TOXICOLOGY

Modulation of Rat Hepatic and Pulmonary Cytochromes P450 and Phase II Enzyme Systems by Erucin, an Isothiocyanate Structurally Related to Sulforaphane

(2008) Natalya Hanlon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structure–Activity Relationships and Organ Specificity in the Induction of GST and NQO1 by Alkyl-Aryl Isothiocyanates

(2008) Rex Munday et al.   PHARMACEUTICAL RESEARCH

Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane

(2008) Natalya Hanlon et al.   TOXICOLOGY