Article
Medicine, Research & Experimental
Hongcheng Luo, Deyou Huang, Xionglin Tang, Yu Liu, Qisheng Luo, Chunhong Liu, Huatuo Huang, Wencheng Chen, Zhongquan Qi
Summary: This study found that Beclin-1 protects neurons from damage in cerebral ischemia-reperfusion through non-autophagy-dependent DNA repair processes. Autophagy inhibitors can decrease brain tissue damage and cell apoptosis, but the decrease is not highly correlated with changes in autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Han-Geng Li, Wen-Hua Tian, Cun-Lan Qin, Rong-Rong Ye, Dong-Hua Liu, Hui-Wen Liu
Summary: The study revealed that Uhrf1 plays a protective role in myocardial ischemia-reperfusion injury (MIRI) by regulating mTOR and H3K9me2, promoting cardiomyocyte proliferation and reducing apoptosis.
Review
Medicine, Research & Experimental
N. Bhagya, K. R. Chandrashekar
Summary: This review evaluates the effectiveness of tetrandrine in targeting key proteins in the autophagy pathway to induce anticancer effects. It also discusses the influence of tetrandrine on autophagy regulation and highlights the limitations and future perspectives in developing tetrandrine as a chemotherapeutic drug.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Zhenzhen Liu, Wenting Leng, Jianmin Zhang, Guangru Zhang, Disheng Liu, Zhiyu Zhao, Feng Chen, Yajing Shi, Yingxiang Hao, Jipeng Lv, Zhanhai Wan, Yan Zhang, Xin Liu, Yongqiang Liu, Yufang Leng
Summary: This study highlights the role of miR-146a-5p in regulating autophagy by targeting TXNIP and suggests that miR-146a-5p may be a novel drug target for intestinal I/R therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Dan Wang, Zhenchao Niu, Xiaolong Wang
Summary: This article discusses the regulatory role of non-coding RNAs in myocardial ischemia-reperfusion injury, focusing on their impact on autophagy-related mTOR signaling pathways and mitophagy. Non-coding RNAs may serve as novel clinical diagnostic markers and therapeutic targets in the prediction and treatment of myocardial ischemia-reperfusion injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Han Xu, Jing Cheng, Fei He
Summary: Cordycepin has a cardioprotective effect on myocardial ischemia/reperfusion (I/R) injury by reducing apoptosis and infarct size, improving cardiac function, and enhancing autophagy via the AMPK-mTOR signaling pathway.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Xiaoying Chen, Qingfeng Xie, Ying Zhu, Jiamin Xu, Guoshu Lin, Shujun Liu, Ziren Su, Xiaoping Lai, Qian Li, Jianhui Xie, Xiaobo Yang
Summary: Tetrahydrocurcumin (THC) exerts cardiac protective effects by inhibiting cell autophagy and apoptosis induced by myocardial ischemia-reperfusion injury through activation of the PI3K/AKT/mTOR signaling pathways. THC demonstrates significant cardioprotective effects in rat hearts and H9c2 cells, suggesting its potential as a candidate for the treatment of MI/R injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Neurosciences
Yan-Yan Li, Zheng-Hong Qin, Rui Sheng
Summary: Autophagy plays an important role in neurological diseases by degrading abnormal proteins and damaged organelles, regulating apoptosis and inflammation, and maintaining cellular homeostasis in the nervous system. Multiple signaling pathways are involved in the regulation of autophagy and can serve as potential therapeutic targets for neurological diseases.
NEUROSCIENCE BULLETIN
(2023)
Article
Medicine, Research & Experimental
Ye Fang, Lin Zou, Wei He
Summary: The study demonstrated that miR-30a-5p expression levels were significantly decreased in renal I/R injury, suggesting a potential role in mitigating autophagy by regulating the Beclin-1/ATG16 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Lei Jin, Yun Mo, Er-Li Yue, Yuan Liu, Kang-Yong Liu
Summary: In conclusion, the study demonstrates that ibrutinib shows promising effects in improving cell viability under high glucose and H/R conditions, as well as reducing cerebral infarct volume, improving neurological deficits, and enhancing autophagy in diabetic mice suffering from I/R injury. Additionally, the neuroprotective effects of ibrutinib are associated with the regulation of PI3K/Akt/mTOR signaling pathway.
Review
Medicine, Research & Experimental
Manasi P. Jogalekar, Anurag Veerabathini, Prakash Gangadaran
Summary: Autophagy plays a crucial role in cellular development, diseases, and cancer. Various autophagy modulators have been developed and shown promising results in preclinical trials.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Cell Biology
Yanfei He, Huaqing Lu, Yuting Zhao
Summary: Autophagy activation plays a crucial role in many diseases, but the development of specific activators remains a challenge. Tat-BECN1 peptide is a candidate specific activator that initiates autophagy through specific molecular mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhen Liu, Kai Hu, Yue-Sheng Chen, Ying-Jie Huang, Qian Hu, Wei Zeng, Yue Cao, Qin Xiao, Xue-Kang Zhang
Summary: This study reveals that JAK2/STAT3 signaling pathway suppresses autophagy during intestinal ischemia-reperfusion (I/R), and inhibiting JAK-STAT can protect against I/R injury by activating autophagy, providing new therapeutic targets for clinical treatment.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Neurosciences
Donghai Chen, Kuang Zheng, Henggang Wu, Xuchun Zhang, Wangyang Ye, Xianxi Tan, Ye Xiong
Summary: This study revealed the important role of Lin28a in cerebral ischemia-reperfusion injury, showing that upregulation of Lin28a can alleviate nerve injury and promote autophagy in nerve cells as a protective factor against ischemia-induced damage.
BRAIN RESEARCH BULLETIN
(2021)
Article
Pharmacology & Pharmacy
Jian Zhang, Shiyu Hu, Yang Gao, Xiang Wei, Yanan Qu, Rifeng Gao, Yang Lv, Jingpu Wang, Yiwen Wang, Ji'e Yang, Jiatian Cao, Feng Zhang, Junbo Ge
Summary: This study observed the changes in autophagy after galangin treatment and investigated the cardioprotective effects of galangin on myocardial ischemia-reperfusion injury in both in vivo and in vitro experiments. The results show that galangin treatment can improve cardiac function, reduce infarct size, promote autophagy, and inhibit inflammation. Therefore, galangin can attenuate myocardial ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Mi-Hua Liu
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2015)
Article
Oncology
Mi-Hua Liu, Xiao-Long Lin, Jian Li, Jun He, Tian-Ping Tan, Shao-Jian Wu, Shan Yu, Li Chen, Jun Liu, Wei Tian, Yu-Dan Chen, Hong-Yun Fu, Cong Yuan, Yuan Zhang
MOLECULAR MEDICINE REPORTS
(2016)
Article
Cell Biology
Mi-Hua Liu, Guo-Hua Li, Li-Jun Peng, Shun-Lin Qu, Yuan Zhang, Juan Peng, Xin-Yuan Luo, Heng-Jing Hu, Zhong Ren, Yao Liu, Hui Tang, Lu-Shan Liu, Zhi-Han Tang, Zhi-Sheng Jiang
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2016)
Letter
Cardiac & Cardiovascular Systems
Xiao-Long Lin, Mi-Hua Liu
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Article
Medicine, Research & Experimental
Xiao-Long Lin, Yuanbo Liu, Mihua Liu, Huijun Hu, Yongquan Pan, Xiao-Juan Fan, Xue-Mei Hu, Wei-Wen Zou
MEDICAL SCIENCE MONITOR
(2017)
Review
Medicine, Research & Experimental
Xiao-Long Lin, Le-Le Xiao, Zhi-Han Tang, Zhi-Sheng Jiang, Mi-Hua Liu
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Review
Cardiac & Cardiovascular Systems
Mi-Hua Liu, Zhi-Han Tang, Guo-Hua Li, Shun-Lin Qu, Yuan Zhang, Zhong Ren, Lu-Shan Liu, Zhi-Sheng Jiang
Article
Cell Biology
Mi-Hua Liu, Cong Yuan, Jun He, Tian-Ping Tan, Shao-Jian Wu, Hong-Yun Fu, Jun Liu, Shan Yu, Yu-Dan Chen, Qun-Fang Le, Wei Tian, Heng-Jing Hu, Yuan Zhang, Xiao-Long Lin
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2015)
Article
Oncology
Mi-Hua Liu, Xiao-Long Lin, Le-Le Xiao
Summary: This study found that hydrogen sulfide (H2S) can alleviate macrophage inflammation by regulating the sulfhydration of SIRT1. In addition, H2S also reduces inflammation by inhibiting the expression of inflammatory cytokines and decreasing the phosphorylation of P65 NF-kappa B in TMAO-induced inflammation. Therefore, H2S may be used for the treatment of inflammatory vascular diseases.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Geriatrics & Gerontology
Danyang Li, Mihua Liu, Zhe Li, Guo Zheng, Amei Chen, Lei Zhao, Ping Yang, Li Wei, Yaxi Chen, Xiong Z. Ruan
Summary: The presence of sterol-resistant SCAP in vascular smooth muscle cells of mice induces vascular inflammation, endothelial dysfunction, and accelerates atherosclerosis progression by activating the NLRP3 inflammasome pathway.