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Biochemistry & Molecular Biology
Qing Shi, Xiaofeng Jin, Pingzhao Zhang, Qian Li, Zeheng Lv, Yan Ding, Huiying He, Yijun Wang, Yuanlong He, Xiaying Zhao, Shi-Min Zhao, Yao Li, Kun Gao, Chenji Wang
Summary: This study reveals that SPOP mutations induce non-degradative ubiquitination of p62, leading to suppression of p62-dependent autophagy and decreased Nrf2-mediated transcriptional activation of antioxidant genes, thus promoting tumor formation in SPOP-mutated PCa.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Oncology
Sheng Wang, Wei Feng, Wulin Wang, Xiaoman Ye, Hao Chen, Chunzhao Yu
Summary: This study aims to increase the sensitivity of gemcitabine chemotherapy for pancreatic cancer by silencing the Girdin gene, showing that Girdin may enhance chemotherapy resistance to gemcitabine through regulating autophagy activity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tetsushi Kataura, Elsje G. Otten, Yoana Rabanal-Ruiz, Elias Adriaenssens, Francesca Urselli, Filippo Scialo, Lanyu Fan, Graham R. Smith, William M. Dawson, Xingxiang Chen, Wyatt W. Yue, Agnieszka K. Bronowska, Bernadette Carroll, Sascha Martens, Michael Lazarou, Viktor Korolchuk
Summary: Mitophagy is essential for maintaining cellular homeostasis. The best characterised pathway involves the stabilisation of PINK1 and recruitment of Parkin to damaged mitochondria. NDP52 recognises ubiquitinated mitochondrial proteins and initiates autophagic vesicle formation. This study found that oxidation of NDP52 is crucial for efficient PINK1/Parkin-dependent mitophagy, and proposed that redox sensing allows mitophagy to function as an oxidative stress response.
Article
Biochemistry & Molecular Biology
Eric N. Bunker, Francois Le Guerroue, Chunxin Wang, Marie-Paule Strub, Achim Werner, Nico Tjandra, Richard J. Youle
Summary: This study reveals the mechanisms of Nix-mediated mitophagy and the importance of both the LIR and MER regions. The MER region interacts with the autophagy effector WIPI2 and recruits it to mitochondria, while the LIR region converts the distribution of WIPI2 on mitochondria into puncta. These findings provide valuable insights into the process of Nix-induced mitophagy.
Article
Plant Sciences
Xiaojie Liu, Lu Liu, Xu Wang, Yubin Jin, Shuang Wang, Qin Xie, Yanhe Jin, Mengli Zhang, Yunhe Liu, Jinfeng Li, Zhenya Wang, Xiangjing Fu, Cheng-Yun Jin
Summary: The study aimed to investigate the role of shikonin in bladder cancer and its underlying mechanisms in vitro and in vivo. Shikonin showed selective inhibitory effect on bladder cancer cells without toxicity on normal bladder epithelial cells. Mechanically, shikonin induced necroptosis and impaired autophagic flux through ROS generation. The crosstalk between necroptosis and autophagy was also observed.
Article
Biochemistry & Molecular Biology
Ashari R. Kannangara, Daniel M. Poole, Colten M. McEwan, Joshua C. Youngs, Vajira K. Weerasekara, Alex M. Thornock, Misael T. Lazaro, Eranga R. Balasooriya, Laura M. Oh, Erik J. Soderblom, Jonathan J. Lee, Daniel L. Simmons, Joshua L. Andersen
Summary: ATG9A, a multi-pass transmembrane protein, plays a crucial role in regulating autophagy. It interacts with members of the ULK1 complex and regulators of membrane fusion and vesicle trafficking, marking pathways of ATG9A trafficking through different cellular systems. ATG9A interacts with ATG13-ATG101 independently of ULK1, and deletion of ATG13 or ATG101 causes abnormal accumulation of ATG9A at stalled clusters of certain proteins, which can be rescued by a mutant form of ATG13 lacking ULK1 binding capability.
Article
Oncology
Zhao Zhang, Yongbo Yu, Zhilei Zhang, Dan Li, Zhijuan Liang, Liping Wang, Yuanbin Chen, Ye Liang, Haitao Niu
Summary: This study revealed a novel mechanism for the role of CXCL12 in P62-mediated PDL1 autophagic regulation. Combined application of CXCL12 receptor blocker and PD1/PDL1 blocker can more effectively inhibit PDL1 expression and enhance antitumor immune response. Targeting CAFs-derived CXCL12 may provide an effective strategy for immunotherapy in bladder cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Genetics & Heredity
Xiuying Chen, Li Yu, Junyang Zhou, Ji Ren, Shan Wang, Yujie Tan, Yan Ding
Summary: In esophageal squamous cell carcinoma, both NFE2L2 and SQSTM1 (p62) are upregulated and promote tumor progression and epithelial-mesenchymal transition (EMT) through autophagy activity. Inhibiting both proteins simultaneously can reverse the migration and EMT characteristics of the tumor, suggesting that targeting both proteins may be a viable treatment option for esophageal squamous cell carcinoma.
Article
Biochemistry & Molecular Biology
Cheong-Yong Yun, Nahyun Choi, Jae Un Lee, Eun Jung Lee, Ji Young Kim, Won Jun Choi, Sang Ho Oh, Jong-Hyuk Sung
Summary: This study demonstrated that the marliolide derivative DMF02 can induce melanosome degradation through autophagy pathway by activating Nrf2, leading to reduced melanin pigmentation. Additionally, DMF02 was effective in reducing UVB-induced hyperpigmentation and regulating melanosome degradation via suppression of p62. These findings suggest that Nrf2 activators could be promising therapeutic agents for reducing hyperpigmentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jiamei Zhang, Lu Han, Qinmei Ma, Xiaoping Wang, Jialin Yu, Yanan Xu, Xu Zhang, Xiaoling Wu, Guangcun Deng
Summary: It has been found that RIP3 plays a crucial role in fighting against Mycobacterium tuberculosis (M.tb) infection by promoting autophagy, which enhances host clearance of the bacteria.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Yinfeng Xu, Yaosen Wu, Lei Wang, Zhuo Ren, Lijiang Song, Hui Zhang, Chuying Qian, Qian Wang, Zhengfu He, Wei Wan
Summary: The study uncovered a regulatory role of autophagy in RNA metabolism, showing that autophagy-deficient cells have higher levels of 47S precursor rRNA due to accumulation of SQSTM1. This accumulation potentiates MTORC1 signaling, leading to increased rRNA transcription from rDNA and promoting protein synthesis and cell proliferation.
Review
Pharmacology & Pharmacy
Jacob Cuyler, Pranav Murthy, Neal G. Spada, Terence F. McGuire, Michael T. Lotze, Xiang-Qun Xie
Summary: PDAC is characterized by heightened autophagy and immune dysfunction, and targeting SQSTM-1-dependent autophagy could be a promising treatment strategy for promoting an effective immune response in PDAC.
DRUG DISCOVERY TODAY
(2022)
Retraction
Biochemistry & Molecular Biology
A. Caccamo, E. Ferreira, C. Branca, S. Oddo
Summary: The article has been retracted by the Editor-in-Chief and publisher.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Haifeng Lu, Yugang Wang, Hua Fan, Yiqing Wang, Shenghao Fan, Shimin Hu, Haitao Shen, Haiying Li, Qun Xue, Jianqiang Ni, Qi Fang, Gang Chen
Summary: The mechanisms underlying the regulation of circadian rhythms in relation to the development of brain disorders such as depression, autism, and stroke remain unclear. Glutamate systems and autophagy are thought to play important roles in the pathogenesis of stroke. This study found that GluA1 expression was decreased and autophagic activity was increased during the active phase of stroke in male mouse models. Inhibition of autophagy increased the infarct volume, while activation of autophagy decreased it. Additionally, the circadian rhythm gene Per1 was found to influence GluA1 expression and autophagic activity in stroke.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Liyan Gong, Kaihua Wang, Mengcheng Wang, Ronggui Hu, Huaguang Li, Daming Gao, Moubin Lin
Summary: The study identified the CUL5-ASB6 complex as a mediator of p62 ubiquitination and degradation, with overexpression of ASB6 inhibiting cell proliferation by reducing p62 protein level and affecting autophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
