Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain

Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity

(2017) Takahiro Horiuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Posttranslational Modifications of HMGB1 During Immune Responses

(2016) Yiting Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice

(2016) K. Stark et al.   BLOOD

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice

(2016) Peter Lundbäck et al.   HEPATOLOGY

TLR2 Plays a Critical Role in HMGB1-Induced Glomeruli Cell Proliferation Through the FoxO1 Signaling Pathway in Lupus Nephritis

(2016) Xiao-juan Feng et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia

(2016) Nabanita Das et al.   Cell Reports

MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

(2015) Huan Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

(2014) B. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The noninflammatory role of high mobility group box 1/toll-like receptor 2 axis in the self-renewal of mammary cancer stem cells

(2013) Laura Conti et al.   FASEB JOURNAL

Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent

(2013) Jan Mersmann et al.   MEDIATORS OF INFLAMMATION

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High mobility group box 1 protein synergizes with lipopolysaccharide and peptidoglycan for nitric oxide production in mouse peritoneal macrophages in vitro

(2012) Rituparna Chakraborty et al.   MOLECULAR IMMUNOLOGY

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(2012) Hulda Hreggvidsdottir et al.   MOLECULAR MEDICINE

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(2012) Huan Yang et al.   MOLECULAR MEDICINE

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

(2012) Shigeki Chiba et al.   NATURE IMMUNOLOGY

TLR2 and TLR4 Mediate Differential Responses to Limb Ischemia through MyD88-Dependent and Independent Pathways

(2012) Ulka Sachdev et al.   PLoS One

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model

(2011) Ju Ho Youn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

(2011) Heidi Wähämaa et al.   ARTHRITIS RESEARCH & THERAPY

Tail-Mediated Collapse of HMGB1 Is Dynamic and Occurs via Differential Binding of the Acidic Tail to the A and B Domains

(2010) Katherine Stott et al.   JOURNAL OF MOLECULAR BIOLOGY

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation

(2009) Hulda Sigridur Hreggvidsdottir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

(2009) James F Curtin et al.   PLOS MEDICINE

The Interaction of HMGB1 and Linker Histones Occurs Through their Acidic and Basic Tails

(2008) Laura Cato et al.   JOURNAL OF MOLECULAR BIOLOGY