Review
Cell Biology
Takanobu Tagawa, Anna Serquin, Insun Kook, Joseph Ziegelbauer
Summary: Viral ncRNAs can manipulate host cells without evoking adaptive immune responses and may trigger host innate immune responses. Viruses can encode decoys/inhibitors to counteract and evade these responses, and in addition, ncRNAs can be secreted into the extracellular space, influencing adjacent cells to create a pro-viral microenvironment.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Karthik Dhatchinamoorthy, Jeff D. Colbert, Kenneth L. Rock
Summary: Loss of MHC I antigen presentation is common in many cancers, which may impair immune responses and affect the efficacy of immunotherapy. Studies have discussed underlying mechanisms through which some cancers evade immune killing by shutting down the MHC I pathway, and proposed potential strategies to overcome this limitation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ian Mantel, Barzan A. A. Sadiq, J. Magarian Blander
Summary: This article discusses the importance of the transporter associated with antigen processing (TAP) protein in cellular immune responses, particularly in cross-presentation. TAP plays a crucial role in transporting peptides to the endoplasmic reticulum as well as in phagosomes and endosomes, and its expression and function are often compromised by cancer and viruses.
MOLECULAR IMMUNOLOGY
(2022)
Article
Microbiology
Chenhe Su, Fang Lu, Samantha S. Soldan, R. Jason Lamontagne, Hsin-Yao Tang, Giorgia Napoletani, Paul J. Farrell, Italo Tempera, Andrew V. Kossenkov, Paul M. Lieberman
Summary: The study reveals a new transcriptional mechanism by which EBV encoded EBNA2 down-regulates HLA class II gene expression, impacting T-cell recognition of infected cells. EBNA2 competes with CIITA binding, leading to CIITA transcriptional down-regulation and subsequent HLA-II gene expression attenuation. This indirect regulation is proposed to be due to enhancer competition at neighboring chromosome domains.
Article
Biochemistry & Molecular Biology
Han-Ha Chai, Tae-Hun Kim, Young Ran Kim, Dajeong Lim
Summary: The study predicted the structure of the pig TAP transporter and its inhibition complex by the herpes simplex virus-encoded ICP47 inhibitor, revealing the specificity determinants and functional effects of the ICP47 inhibitor on TAP. The research also demonstrated the specialized structure-function relationship of the pig TAP exporter and its implications for antiviral resistance and disease susceptibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Virology
Nicole Mihelson, Dorian B. McGavern
Summary: Glioblastoma multiforme (GBM) is a deadly cancer of the central nervous system with limited treatment options. Virotherapy shows promising results in overcoming the challenges posed by GBM and achieving success in treatment.
Review
Pharmacology & Pharmacy
Mabroka H. Saad, Raied Badierah, Elrashdy M. Redwan, Esmail M. El-Fakharany
Summary: Exosomes, as a subtype of extracellular vesicles, play crucial roles in cellular communication and immune modulation. Recent studies have shown that many viruses exploit exosomes to export viral elements, influencing viral propagation and cellular immunity. Understanding exosome biology in viral infections is essential for developing novel therapeutic strategies and vaccines.
Article
Multidisciplinary Sciences
Caitlin E. Pegg, Sofia Zaichick, Ewa Bomba-Warczak, Vladimir Jovasevic, DongHo Kim, Himanshu Kharkwal, Duncan W. Wilson, Derek Walsh, Patricia J. Sollars, Gary E. Pickard, Jeffrey N. Savas, Gregory A. Smith
Summary: Neurotropic alphaherpesviruses infect exposed mucosal tissues and spread rapidly to sensory and autonomic nerves to establish lifelong latency. The viruses utilize a cellular kinesin motor to transport to neuronal nuclei, which is crucial for their neuroinvasive capability. These findings may have implications for other virus families and suggest new strategies for combating infections.
Review
Immunology
Xiaochun Xie, Jianxiong Zeng
Summary: Zika virus targets neural stem cells and progenitor cells, causing fetal microcephaly and other congenital malformations. The virus has developed a complex strategy of neuroimmune evasion to facilitate viral pathogenesis, especially in embryonic brain development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Immunology
Debipreeta Bhowmik, Fanxiu Zhu
Summary: Sensing viral constituents is crucial for host immune defense against viruses. Host DNA sensors have been discovered and their mechanisms elucidated, but herpesviruses employ diverse strategies to evade host DNA sensing.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Immunology
Jingyun Wang, Keying Liang, Li Chen, Xiaoling Su, Daoyong Liao, Jianwei Yu, Jun He
Summary: Mycoplasmas, the smallest self-replicating organisms, are capable of causing infections in humans and animals. They have developed various evasion strategies to avoid immune responses, including invasion, biofilm formation, and modulation of immune reactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Uxia Gestal-Mato, Lina Herhaus
Summary: The major histocompatibility complex (MHC) class I presents peptide antigens to CD8+ T lymphocytes to trigger immune response. Besides the conventional antigen-processing pathway, autophagy also plays a role in MHC-I peptide loading and presentation. This review article explores the involvement of autophagy in MHC class I-restricted antigen presentation and its potential implications in T cell immunotherapies.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Najla Arshad, Maudry Laurent-Rolle, Wesam S. Ahmed, Jack Chun-Chieh Hsu, Susan M. Mitchell, Joanna Pawlak, Debrup Sengupta, Kabir H. Biswas, Peter Cresswell
Summary: Two accessory proteins encoded by SARS-CoV-2, ORF3a and ORF7a, down-regulate MHC-I expression through distinct mechanisms, reducing surface MHC-I levels and enabling immune evasion by the virus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Microbiology
Chonghui Xu, Jizheng Chen, Xinwen Chen
Summary: Hepatitis viruses are the primary causative agents of hepatitis and pose a major public health issue globally. The host innate immune system acts as the first line of defense against these viruses. However, hepatitis viruses evade host immune surveillance through various strategies, compromising the innate immune response and creating a favorable environment for viral replication.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Huimin Hu, Ming Fu, Chuntian Li, Binman Zhang, Yuncheng Li, Qinxue Hu, Mudan Zhang
Summary: HSV-2 inhibits the activation of NF-kappa B through the immediate early protein ICP22, suggesting a novel mechanism by which HSV-2 evades the host antiviral responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dani A. C. Heesterbeek, Bart W. Bardoel, Edward S. Parsons, Isabel Bennett, Maartje Ruyken, Dennis J. Doorduijn, Ronald D. Gorham, Evelien T. M. Berends, Alice L. B. Pyne, Bart W. Hoogenboom, Suzan H. M. Rooijakkers
Article
Virology
Jelle de Wit, Maarten E. Emmelot, Martien C. M. Poelen, Josien Lanfermeijer, Wanda G. H. Han, Odle A. C. M. van Els, Patricia Kaaijk
JOURNAL OF VIROLOGY
(2019)
Review
Immunology
Sara P. H. van den Berg, Iris N. Pardieck, Josien Lanfermeijer, Delphine Sauce, Paul Klenerman, Debbie van Baarle, Ramon Arens
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2019)
Correction
Multidisciplinary Sciences
Rutger D. Luteijn, Shivam A. Zaver, Benjamin G. Gowen, Stacia K. Wyman, Nick E. Garelis, Liberty Onia, Sarah M. McWhirter, George E. Katibah, Jacob E. Corn, Joshua J. Woodward, David H. Raulet
Review
Cell Biology
Josien Lanfermeijer, Jose A. M. Borghans, Debbie van Baarle
Article
Cell Biology
Rutger D. Luteijn, Patrique Praest, Frank Thiele, Saravanan Manikam Sadasivam, Katrin Singethan, Jan W. Drijfhout, Christian Bach, Steffen Matthijn de Boer, Robert J. Lebbink, Sha Tao, Markus Helfer, Nina C. Bach, Ulrike Protzer, Ana I. Costa, J. Antoinette Killian, Ingo Drexler, Emmanuel J. H. J. Wiertz
Article
Biochemistry & Molecular Biology
A. B. C. Schuren, I. G. J. Boer, E. M. Bouma, M. L. van de Weijer, A. I. Costa, P. Hubel, A. Pichlmair, R. J. Lebbink, E. J. H. J. Wiertz
Summary: The study explores the molecular mechanisms of ER-associated protein degradation (ERAD), involving chaperones' quality control, degradation by the ubiquitin-proteasome system, and US2-mediated fast ERAD. In investigating the degradation of HLA-I mediated by US2, it was found that the UFM1 pathway also impacts ERAD.
Article
Food Science & Technology
Ana Isabel de Almeida Costa, Carla Marano-Marcolini, Manuel Malfeito-Ferreira, Virgilio Loureiro
Summary: This study identified the authenticity attributes of Historical Wines of Portugal (HWP) through interviews with Portuguese wine producers and consumers, as well as an online questionnaire with Portuguese wine consumers. It found that wine knowledge significantly influenced consumer associations with HWP, and that different types of consumers showed varying degrees of association with HWP attributes.
Article
Immunology
Josien Lanfermeijer, Marieke M. Nuehn, Maarten E. Emmelot, Martien C. M. Poelen, Cecile A. C. M. van Els, Jose A. M. Borghans, Debbie van Baarle, Patricia Kaaijk, Jelle de Wit
Summary: Decrease in MuV-specific humoral response after vaccination may contribute to recent mumps outbreaks, but CD8(+) T cells could play a key role in the immune response against MuV. The frequency of MuV-specific CD8(+) T cells in the blood declines within 9 months post-infection, although the TCR beta analysis reveals a stable MuV-specific T-cell repertoire over time.
Editorial Material
Microbiology
Rutger D. Luteijn, Frank J. M. van Kuppeveld
NATURE MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Ana Cecilia Barbosa, Ana Isabel Costa, Silvia Garcia, Rosana Dias, Edgar Mesquita
Summary: This study developed and validated a scale called AnsT-19 to assess the anxiety of family physicians during teleconsultation. The results showed that the scale had good properties and validity in terms of factor structure, convergent validity, and predictive validity.
ACTA MEDICA PORTUGUESA
(2023)
Article
Medicine, Research & Experimental
Cassandra Maya, Luis Miguel Cunha, Ana Isabel de Almeida Costa, Teun Veldkamp, Nanna Roos
Summary: This study aims to investigate the impact of plant and insect-based foods on replacing meat protein, focusing on changes in meat protein intake and the proportion of plant/insect protein. The results will provide valuable data and insights for the field of alternative proteins.
Article
Multidisciplinary Sciences
Koen van de Ven, Josien Lanfermeijer, Harry van Dijken, Hiromi Muramatsu, Caroline Vilas Boas de Melo, Stefanie Lenz, Florence Peters, Mitchell B. Beattie, Paulo J. C. Lin, Jose A. Ferreira, Judith van den Brand, Debbie van Baarle, Norbert Pardi, Jorgen de Jonge
Summary: This study evaluated a novel T cell-inducing nucleoside-modified messenger RNA (mRNA) vaccine that encoded conserved proteins of an H1N1 influenza virus, and found that it induced broadly reactive T cells and enhanced protection against potential influenza viruses.
Article
Economics
Julio Lobao, Ana Isabel Costa
CUADERNOS DE ECONOMIA-SPAIN
(2020)