Article
Biotechnology & Applied Microbiology
Okhee Choi, Jaeyeong Cho, Byeongsam Kang, Yeyeong Lee, Jinwoo Kim
Summary: This study identified the essential role of two siderophores, aerobactin and desferrioxamine E, in the antibacterial activity of P. ananatis PA13. The biosynthetic gene clusters of these siderophores were found to be negatively regulated by the Fur protein. Siderophore production was not required for P. ananatis virulence in plants, but it appears to be involved in the microbial ecology surrounding the plant environment.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Oncology
Valentina Pita-Grisanti, Kaylin Chasser, Trevor Sobol, Zobeida Cruz-Monserrate
Summary: Siderophores are iron chelating molecules produced by bacteria that play a crucial role in iron homeostasis and interspecies competition. They have potential in cancer treatment, but research is limited and their use may have both risks and benefits.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vladimir Gorshkov, Olga Parfirova, Olga Petrova, Natalia Gogoleva, Evgeny Kovtunov, Vladimir Vorob'ev, Yuri Gogolev
Summary: Enterobactin can be considered as a conditionally beneficial virulence factor for Pba, as the entA knockout does not reduce its virulence on non-primed plants, but makes salicylic acid-primed plants more resistant to the Delta entA mutant. The reduced virulence of the mutant towards primed plants is likely due to its compromised resistance to oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Matthew B. Nodwell, Robert Britton
Summary: A solid-phase platform for the precise synthesis of enterobactin analogues was described, revealing structure-activity relationships for growth promotion in P. aeruginosa by certain HEHC analogues.
ACS INFECTIOUS DISEASES
(2021)
Article
Microbiology
Christian Hintersatz, Shalini Singh, Luis Antonio Rojas, Jerome Kretzschmar, Sean Ting-Shyang Wei, Khushal Khambhati, Sabine Kutschke, Falk Lehmann, Vijai Singh, Rohan Jain, Katrin Pollmann
Summary: This study aimed to identify and characterize novel siderophore-producing organisms from hypersaline, alkaline surface waters. Two halophilic strains designated ATCHA(T) and ATCH28(T) were isolated, and their affiliation with the genus Halomonas was determined. Both strains were found to secrete siderophores based on the CAS assay and genomic analysis. Strain ATCH28(T) was found to produce a non-amphiphilic siderophore called desferrioxamine E (DFOE), and the quantity of DFOE secretion could be increased through media optimization. These findings contribute to the understanding of siderophore production in halophilic microorganisms and propose two new species of the genus Halomonas.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Katsushiro Miyamoto, Hiroaki Kawano, Naoko Okai, Takeshi Hiromoto, Nao Miyano, Koji Tomoo, Takahiro Tsuchiya, Jun Komano, Tomotaka Tanabe, Tatsuya Funahashi, Hiroshi Tsujibo
Summary: Vibrio vulnificus M2799 secretes the catecholate siderophore vulnibactin to capture ferric ions for growth, utilizing a ferric-import system composed of various proteins including an isochorismate synthase and an outer membrane receptor. In infectious diseases, periplasmic-binding proteins and ferric-chelate reductases involved in the ferric-siderophore utilization system could be potential targets for drug discovery.
Article
Chemistry, Analytical
Matthew Kirby, Dominik J. Weiss
Summary: A pilot study investigates the potential of desferrioxamine B (DFOB) to prevent U-VI precipitation in alkaline NaCl solutions. The results show that DFOB can quantitatively prevent U-VI precipitation as >= 0.2 mu m precipitates when present at concentrations of 130 mu M and 420 mu M in solution. The impact decreases as the concentration decreases, suggesting a lesser mobilizing effect on uranium in a geological disposal facility.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2022)
Review
Biochemical Research Methods
Girish Swayambhu, Michael Bruno, Andrew M. Gulick, Blaine A. Pfeifer
Summary: Siderophore natural products are characterized by their ability to tightly chelate metals, with origins often found in pathogenic microbes. Despite the traditional association with pathogenicity, the evolutionarily-optimized binding abilities of siderophores suggest potential for redirection towards alternative beneficial applications.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Microbiology
William Santus, Amisha P. Rana, Jason R. Devlin, Kaitlyn A. Kiernan, Carol C. Jacob, Joshua Tjokrosurjo, David M. Underhill, Judith Behnsen
Summary: This study investigated the functional relationships between gut bacteria and fungi during infectious colitis. The researchers found that fungi present in both the gut microbiota and diet can provide siderophores, small molecules that scavenge iron from the host, giving a competitive advantage to certain Salmonella strains. This study reveals the importance of inter-kingdom cross-feeding between fungi and Salmonella and sheds light on the additional function of the gut mycobiota during bacterial infection.
NATURE MICROBIOLOGY
(2022)
Review
Chemistry, Organic
Philipp Klahn, Robert Zscherp, Claire C. Jimidar
Summary: Iron is essential for bacterial growth, and bacteria produce and secrete siderophores, such as enterobactin and salmochelins, to ensure their supply of iron. The synthesis and design of these compounds are of great importance for the development of antimicrobial drugs and tools for detecting bacterial infections.
SYNTHESIS-STUTTGART
(2022)
Article
Microbiology
D. L. Itkina, A. D. Suleimanova, M. R. Sharipova
Summary: The biocontrol mechanisms of Pantoea brenneri AS3 and Bacillus ginsengihumi M2.11 strains were studied, revealing their abilities to release ammonium and cyanide ions, produce cellulase and protease, fix nitrogen, mobilize soil phosphates and phytates, synthesize siderophores, and produce the phytohormone indoleacetic acid (IAA). Both strains exhibited fungicidal activity against Fusarium species, making them potential candidates for biofertilizers and plant growth stimulators.
Article
Materials Science, Multidisciplinary
S. Perez-Miranda, L. S. Zamudio-Rivera, R. Cisneros-Devora, R. George-Tellez, F. J. Fernandez
Summary: The research found that the hydroxamate functional group is the best corrosion inhibitor, and desferrioxamine B can act as an ecological corrosion inhibitor at minimal concentrations. Additionally, the experiments demonstrated that desferrioxamine B can effectively control corrosion problems in acidic environments characteristic of the oil industry.
CORROSION ENGINEERING SCIENCE AND TECHNOLOGY
(2021)
Article
Forestry
Stavroula Rapti, Stamatis Boyatzis, Shayne Rivers, Athanasios Velios, Anastasia Pournou
Summary: This study investigated the potential of desferrioxamine B (DFO-B) as a chelator for removing ferric oxides/hydroxy-oxides from cultural heritage wooden substrates. The results showed that the alkaline hydrogel (pH 8.6) was the most effective formulation, followed by the acidic hydrogel (pH 6.5) and DFO-B ethanol gel. The DFO-B ethanol gels also showed potential as alternatives to hydrogels for water-sensitive cultural heritage substrates.
Article
Multidisciplinary Sciences
Nuria Marti Gutierrez, Aleksei Mikhalchenko, Hong Ma, Amy Koski, Ying Li, Crystal Van Dyken, Rebecca Tippner-Hedges, David Yoon, Dan Liang, Tomonari Hayama, David Battaglia, Eunju Kang, Yeonmi Lee, Anthony Paul Barnes, Paula Amato, Shoukhrat Mitalipov
Summary: Cells can acquire mitochondrial DNA (mtDNA) from other cells without a parent-offspring relationship, and this acquisition can occur at high levels. The transfer of mtDNA may serve as a compensatory mechanism to restore compromised mitochondrial function. These findings have important implications for understanding mtDNA transfer and developing gene therapies.
Article
Biotechnology & Applied Microbiology
Joshua G. Philips, Elena Martin-Avila, Andrea V. Robold
Summary: This review provides updated evidence on the likelihood, factors, and barriers for horizontal gene transfer in genetically modified plants, and presents the legislation and frameworks followed by the Australian Gene Technology Regulator in considering the risks posed by horizontal gene transfer.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Craig D. Soutar, John Stavrinides
Article
Microbiology
Craig D. Soutar, John Stavrinides
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Craig D. Soutar, John Stavrinides
Summary: This study conducted a taxogenomic analysis of the Erwiniaceae family and proposed the reclassification of several species within the genus Erwinia. The findings suggest the possible subdivision of the genus Erwinia and provided insights into the diversity of the Erwiniaceae family. These results lay a solid foundation for advancing the taxonomic revision of this broadly relevant family.
MOLECULAR GENETICS AND GENOMICS
(2022)
Article
Immunology
Arthur H. Totten, Gulbu Uzel, Pavel P. Khil, Jung-Ho Youn, Jennifer Treat, Craig D. Soutar, Steven M. Holland, John P. Dekker, Christa S. Zerbe
Summary: The article describes 2 cases of PI3KR1 deficiency with invasive Mycoplasma orale infection, emphasizing that PI3KR1 mutations predispose to infections and autoimmune diseases, and mentioning that Mycoplasma orale is a pathobiont that causes rare diseases in immunodeficient hosts.
OPEN FORUM INFECTIOUS DISEASES
(2022)