Article
Ecology
Aaron A. Vogan, Jesper Svedberg, Magdalena Grudzinska-Sterno, Hanna Johannesson
Summary: This study reveals the role of meiotic drive in the formation of Bateson-Dobzhansky-Muller (BDM) incompatibilities. Using the model fungus Neurospora, the researchers demonstrate that the large meiotic drive haplotypes Sk-2 and Sk-3 contain putative sexual incompatibilities. Their experiments show that when strains of N. intermedia carry Sk-2 or Sk-3, the proportion of viable progeny drops substantially, indicating the contribution of meiotic drive to reproductive isolation and speciation.
Article
Biochemistry & Molecular Biology
Madhav Jagannathan, Yukiko M. Yamashita
Summary: The inefficient clustering of divergent satellite DNA in Drosophila hybrid cells leads to chromocenter disruption, micronuclei formation, and tissue atrophy, which is linked to the reproductive isolation between closely related species.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Ecology
Christina A. Muirhead, Daven C. Presgraves
Summary: Sex chromosomes are susceptible to selfish meiotic drive elements that can lead to evolutionary arms races and genetically suppressed drive systems. In Drosophila species, complex interactions among different classes of selfish DNAs result in the genomic consequences of these evolutionary arms races.
NATURE ECOLOGY & EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Cecile Courret, David Ogereau, Clement Gilbert, Amanda M. Larracuente, Catherine Montchamp-Moreau
Summary: The recent evolution of the Y chromosome in Drosophila simulans is closely linked to X-linked meiotic drivers. The spread of the drivers has led to the selection of drive-resistant Y chromosomes. Through sequencing, it has been found that sensitive Y chromosomes, despite their different origins, are highly similar, suggesting a recent common ancestor. Resistant Y chromosomes are more divergent and segregate into four distinct clusters.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Review
Biology
Matthias Stoeck, Dmitrij Dedukh, Radka Reifova, Dunja K. Lamatsch, Zuzana Starostova, Karel Janko
Summary: The roles of sex chromosomes in vertebrate hybridization and speciation are dependent on the level of divergence, affecting the degree of reproductive isolation. Undifferentiated sex chromosomes are more susceptible to introgression and may give rise to new sex chromosome systems.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jesper Svedberg, Aaron A. Vogan, Nicholas A. Rhoades, Dilini Sarmarajeewa, David J. Jacobson, Martin Lascoux, Thomas M. Hammond, Hanna Johannesson
Summary: This study identifies the gene responsible for spore killing in the Sk-1 element in the filamentous ascomycete Neurospora sitophila, naming it Spk-1. Through molecular dissection and phylogenetic analysis, the study shows that Spk-1 likely originated from a closely related species and that spore killing can be suppressed through an RNA interference-based genome defense pathway. Spk-1 is unique to Neurospora and sheds light on meiotic drive genes and their interaction with the host genome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Silu Wang, Matthew J. Nalley, Kamalakar Chatla, Reema Aldaimalani, Ailene MacPherson, Kevin H-C Wei, Russell B. Corbett-Detig, Dat Mai, Doris Bachtrog
Summary: This study describes the conflicting roles of nascent sex chromosomes on introgression patterns in an experimental hybrid swarm. The researchers found that a large block containing overlapping inversions on the neo-sex chromosome acted as the strongest barrier to introgression. The study also investigated the interplay of sex chromosome drive, heterospecific pairing incompatibility, neo-Y disadvantage, and neo-X advantage in generating the observed introgression patterns.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Genetics & Heredity
Carl Mackintosh, Andrew Pomiankowski, Michael F. Scott
Summary: X-linked meiotic drivers can lead to an imbalance in sex ratios by producing an excess of X-bearing sperm in male carriers. The spread and fixation of X-linked alleles depend on sex-specific selection and transmission, rather than time spent in each sex. These drivers can enhance population size and persistence by increasing productivity, but can also lead to population extinction if the sex ratio becomes too skewed.
Article
Cell Biology
Findley Finseth
Summary: Female meiosis is asymmetric, providing a platform for genetic elements to compete for inclusion in the egg. Centromeres can evolve through 'female meiotic drive', which creates an arms race between selfish centromeres and kinetochore proteins. This study focuses on maize as a model to understand the mechanistic basis of female meiotic drive and monkeyflowers as a model to uncover the dynamics of active selfish centromeres in nature.
CURRENT OPINION IN GENETICS & DEVELOPMENT
(2023)
Article
Biochemistry & Molecular Biology
Matthew A. Conte, Frances E. Clark, Reade B. Roberts, Luohao Xu, Wenjing Tao, Qi Zhou, Deshou Wang, Thomas D. Kocher
Summary: This study investigates the evolution of a giant sex chromosome in cichlid fish, finding that it consists of three distinct regions and contains unprecedented amounts of endogenous retroviral elements, immunoglobulin genes, and long non-coding RNAs. Comparative analysis across 69 teleost genomes supports the hypothesis that the giant sex chromosome originated from the fusion of a B chromosome.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Review
Biochemistry & Molecular Biology
Frances E. Clark, Takashi Akera
Summary: Female meiotic drive is a phenomenon where a selfish genetic element alters chromosome segregation during female meiosis to transmit more frequently to the next generation. Despite known examples for many years, a molecular understanding of the underlying mechanisms has been challenging. Recent advances in several model species have prompted a comparative re-examination of these drive systems.
Review
Genetics & Heredity
Krishna B. S. Swamy, Scott C. Schuyler, Jun-Yi Leu
Summary: Proteins in cells form complexes through interactions, executing functions; inter-species hybrid offspring are often inviable or sterile due to genetic differences; Understanding protein interactions and omics technologies are key in characterizing multi-locus incompatibilities.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Jiri Forejt, Petr Jansa
Summary: Hybrid sterility is an early reproductive isolation mechanism in sexually reproducing species, preventing gene flow and leading to speciation. Increasing DNA divergence between closely related species may impair homologous chromosome recognition and disrupt synapsis, resulting in early meiotic arrest or aneuploidy. Impaired recognition of homologs acts as a universal chromosomal checkpoint in hybrid sterility, and examples such as the Prdm9 gene in mice and mismatch repair machinery in yeast demonstrate chromosomal homology search-based hybrid sterility. Further investigation of meiosis at the cellular and molecular level is needed to validate the role of homolog recognition in hybrid sterility and speciation.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Ecology
Kelsie A. Lopez, Callum S. McDiarmid, Simon C. Griffith, Irby J. Lovette, Daniel M. Hooper
Summary: Through the study of long-tailed finches in Australia, it was discovered that there are discrepancies in the geographical locations of mitochondrial and Z chromosome admixture in hybrid zones, indicating the presence of sex chromosome incompatibilities and mitonuclear mismatches.
Review
Immunology
Kelly Z. Z. Young, Peter Dimitrion, Li Zhou, Indra Adrianto, Qing-Sheng Mi
Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by abscesses, sinus tracts, and scarring. HS has a strong female sex bias, and this article reviews the role of intrinsic and extrinsic factors in sex-related differences in immunity and their potential role in HS pathophysiology. Hormones, X chromosome dosage, genetics, the microbiome, and smoking are discussed as possible factors contributing to sex-related differences in immunity and HS disease presentations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Ecology
Charles Y. Feigin, Axel H. Newton, Liliya Doronina, Juergen Schmitz, Christy A. Hipsley, Kieren J. Mitchell, Graham Gower, Bastien Llamas, Julien Soubrier, Thomas N. Heider, Brandon R. Menzies, Alan Cooper, Rachel J. O'Neill, Andrew J. Pask
NATURE ECOLOGY & EVOLUTION
(2018)
Review
Biochemistry & Molecular Biology
Savannah J. Klein, Rachel J. O'Neill
CHROMOSOME RESEARCH
(2018)
Editorial Material
Cell Biology
Rachel J. O'Neill, Michael J. O'Neill
JOURNAL OF CELL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Judy Brown, Julianna Crivello, Rachel J. O'Neill
Article
Genetics & Heredity
Rebecca N. Johnson, Denis O'Meally, Zhiliang Chen, Graham J. Etherington, Simon Y. W. Ho, Will J. Nash, Catherine E. Grueber, Yuanyuan Cheng, Camilla M. Whittington, Siobhan Dennison, Emma Peel, Wilfried Haerty, Rachel J. O'Neill, Don Colgan, Tonia L. Russell, David E. Alquezar-Planas, Val Attenbrow, Jason G. Bragg, Parice A. Brandies, Amanda Yoon-Yee Chong, Janine E. Deakin, Federica Di Palma, Zachary Duda, Mark D. B. Eldridge, Kyle M. Ewart, Carolyn J. Hogg, Greta J. Frankham, Arthur Georges, Amber K. Gillett, Merran Govendir, Alex D. Greenwood, Takashi Hayakawa, Kristofer M. Helgen, Matthew Hobbs, Clare E. Holleley, Thomas N. Heider, Elizabeth A. Jones, Andrew King, Danielle Madden, Jennifer A. Marshall Graves, Katrina M. Morris, Linda E. Neaves, Hardip R. Patel, Adam Polkinghorne, Marilyn B. Renfree, Charles Robin, Ryan Salinas, Kyriakos Tsangaras, Paul D. Waters, Shafagh A. Waters, Belinda Wright, Marc R. Wilkins, Peter Timms, Katherine Belov
Article
Biotechnology & Applied Microbiology
Marilyn B. Renfree, Anthony T. Papenfuss, Janine E. Deakin, James Lindsay, Thomas Heider, Katherine Belov, Willem Rens, Paul D. Waters, Elizabeth A. Pharo, Geoff Shaw, Emily Swwong, Christophe M. Lefevre, Kevin R. Nicholas, Yoko Kuroki, Matthew J. Wakefield, Kyall R. Zenger, Chenwei Wang, Malcolm Ferguson-Smith, Frank W. Nicholas, Danielle Hickford, Hongshi Yu, Kirsty R. Short, Hannah V. Siddle, Stephen R. Frankenberg, Keng Yih Chew, Brandon R. Menzies, Jessica M. Stringer, Shunsuke Suzuki, Timothy A. Hore, Margaret L. Delbridge, Amir Mohammadi, Nanette Y. Schneider, Yanqiu Hu, William O'Hara, Shafagh Al Nadaf, Chen Wu, Zhi-Ping Feng, Benjamin G. Cocks, Jianghui Wang, Paul Flicek, Stephen M. J. Searle, Susan Fairley, Kathryn Beal, Javier Herrero, Dawn M. Carone, Yutaka Suzuki, Sumio Sugano, Atsushi Toyoda, Yoshiyuki Sakaki, Shinji Kondo, Yuichiro Nishida, Shoji Tatsumoto, Ion Mandiou, Arthur Hsu, Kaighin A. McColl, Benjamin Lansdell, George Weinstock, Elizabeth Kuczek, Annette McGrath, Peter Wilson, Artem Men, Mehlika Hazar-Rethinam, Allison Hall, John Davis, David Wood, Sarah Williams, Yogi Sundaravadanam, Donna M. Muzny, Shalini N. Jhangiani, Lora R. Lewis, Margaret B. Morgan, Geoffrey O. Okwuonu, San Juana Ruiz, Jireh Santibanez, Lynne Nazareth, Andrew Cree, Gerald Fowler, Christie L. Kovar, Huyen H. Dinh, Vandita Joshi, Chyn Jing, Fremiet Lara, Rebecca Thornton, Lei Chen, Jixin Deng, Yue Liu, Joshua Y. Shen, Xing-Zhi Song, Janette Edson, Carmen Troon, Daniel Thomas, Amber Stephens, Lankesha Yapa, Tanya Levchenko, Richard A. Gibbs, Desmond W. Cooper, Terence P. Speed, Asao Fujiyama, Jennifer A. M. Graves, Rachel J. O'Neill, Andrew J. Pask, Susan M. Forrest, Kim C. Worley
Article
Biochemistry & Molecular Biology
Brendan M. Smalec, Thomas N. Heider, Brianna L. Flynn, Rachel J. O'Neill
CHROMOSOME RESEARCH
(2019)
Review
Biochemistry & Molecular Biology
Rachel J. O'Neill
CHROMOSOME RESEARCH
(2020)
Article
Multidisciplinary Sciences
Mariam Okhovat, Kimberly A. Nevonen, Brett A. Davis, Pryce Michener, Samantha Ward, Mark Milhaven, Lana Harshman, Ajuni Sohota, Jason D. Fernandes, Sofie R. Salama, Rachel J. O'Neil, Nadav Ahituv, Krishna R. Veeramah, Lucia Carbone
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Gabrielle A. Hartley, Mariam Okhovat, Rachel J. O'Neill, Lucia Carbone
Summary: The study reveals dynamic shifts in the repeat content that define gibbon centromeres, with the presence of retroelements dominating the centromeric repeat sequences across gibbon genera. Hoolock centromeres show an independent evolutionary trajectory compared to other genera, with the presence of retroelement-derived macrosatellite SST1. Additionally, transcripts originating from gibbon centromeres recapitulate the species-specific TE composition, indicating evolutionary divergence within the gibbon lineage.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Editorial Material
Multidisciplinary Sciences
Harris A. Lewin, Stephen Richards, Erez Lieberman Aiden, Miguel L. Allende, John M. Archibald, Miklos Balint, Katharine B. Barker, Bridget Baumgartner, Katherine Belov, Giorgio Bertorelle, Mark L. Blaxter, Jing Cai, Nicolette D. Caperello, Keith Carlson, Juan Carlos Castilla-Rubio, Shu-Miaw Chaw, Lei Chen, Anna K. Childers, Jonathan A. Coddington, Dalia A. Conde, Montserrat Corominas, Keith A. Crandall, Andrew J. Crawford, Federica DiPalma, Richard Durbin, ThankGod E. Ebenezer, Scott V. Edwards, Olivier Fedrigo, Paul Flicek, Giulio Formenti, Richard A. Gibbs, M. Thomas P. Gilbert, Melissa M. Goldstein, Jennifer Marshall Graves, Henry T. Greely, Igor V. Grigoriev, Kevin J. Hackett, Neil Hall, David Haussler, Kristofer M. Helgen, Carolyn J. Hogg, Sachiko Isobe, Kjetill Sigurd Jakobsen, Axel Janke, Erich D. Jarvis, Warren E. Johnson, Steven J. M. Jones, Elinor K. Karlsson, Paul J. Kersey, Jin-Hyoung Kim, W. John Kress, Shigehiro Kuraku, Mara K. N. Lawniczak, James H. Leebens-Mack, Xueyan Li, Kerstin Lindblad-Toh, Xin Liu, Jose V. Lopez, Tomas Marques-Bonet, Sophie Mazard, Jonna A. K. Mazet, Camila J. Mazzoni, Eugene W. Myers, Rachel J. O'Neill, Sadye Paez, Hyun Park, Gene E. Robinson, Cristina Roquet, Oliver A. Ryder, Jamal S. M. Sabir, H. Bradley Shaffer, Timothy M. Shank, Jacob S. Sherkow, Pamela S. Soltis, Boping Tang, Leho Tedersoo, Marcela Uliano-Silva, Kun Wang, Xiaofeng Wei, Regina Wetzer, Julia L. Wilson, Xun Xu, Huanming Yang, Anne D. Yoder, Guojie Zhang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
