Retraction
Cell Biology
Xinggang Guo, Hongqi Xiao, Sihong Guo, Jing Li, Yuxia Wang, Jie Chen, Ge Lou
Summary: The article published on October 26, 2018, has been retracted due to flaws and inconsistencies between results presented and experimental methods described, rendering the conclusions invalid.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Fisheries
Qing Chu, Jingjing Han, Lingping Sun, Junxia Cui, Tianjun Xu
Summary: MDA5, a crucial member of RIG-I-like receptors, plays a significant role in antiviral immune response. MicroRNAs have been discovered to regulate the RLR signaling pathway, with miR-203 directly negatively regulating MDA5 in miiuy croaker. This study sheds light on miRNA-mediated regulation of immune responses and cytokine suppression in teleost fish, offering new insights for mammalian immune response studies.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Cell Biology
Anli Yang, Fu Peng, Lewei Zhu, Xing Li, Shunling Ou, Zhongying Huang, Song Wu, Cheng Peng, Peng Liu, Yanan Kong
Summary: Melatonin treatment downregulated FUNDC1 and lnc049808 in TNBC cell lines, which inhibited cell proliferation, invasion, and metastasis. lnc049808 and FUNDC1 acted as competing endogenous RNAs binding to miR-101, indicating a potential therapeutic pathway for TNBC progression inhibition by melatonin.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Iveta Yotova, Quanah J. Hudson, Florian M. Pauler, Katharina Proestling, Isabella Haslinger, Lorenz Kuessel, Alexandra Perricos, Heinrich Husslein, Rene Wenzl
Summary: LINC01133 is upregulated in endometriosis and may affect pathogenesis through cellular proliferation and migration pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Xiaobo Zhang, Jun Xie, Hongmei Sun, Qin Wei, Guangmin Nong
Summary: Research on neutrophilic asthma (NA) suggests that decreased miR-29a-3p and elevated SPARC levels are associated with EMT in the mouse model, where SPARC induces EMT in 16HBE cells and miR-29a-3p can regulate this process.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Paola Briata, Luca Mastracci, Ettore Zapparoli, Luca Caputo, Elisa Ferracci, Alessandra Silvestri, Anna Garuti, Meriem Hadjer Hamadou, Alberto Inga, Elisa Marcaccini, Federica Grillo, Gabriele Bucci, Pier Lorenzo Puri, Galina Beznoussenko, Alexander Mironov, Fulvio Chiacchiera, Roberto Gherzi
Summary: The long non-coding RNA EPR regulates various biological activities in mouse mammary gland cells and is highly expressed in the intestine. The specific deletion of EPR in the colon of mice results in hyperproliferation of epithelial cells, impaired mucus production and secretion, inflammatory infiltration, and increased vulnerability to colitis and tumor formation. EPR interacts with genes involved in mucus metabolism and its deletion causes changes in chromatin organization.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Medicine, Research & Experimental
Jia-Qi Sheng, Mu-Ru Wang, Dan Fang, Lian Liu, Wen-Jie Huang, De-An Tian, Xing-Xing He, Pei-Yuan Li
Summary: Long noncoding RNA NBR2 acts as a tumor suppressor gene in hepatocellular carcinoma, inhibiting cell proliferation, invasion, and migration, as well as promoting proliferation by repressing autophagy. The study provides a novel treatment strategy for hepatocellular carcinoma.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Mahsa Golshan, Saeedeh Khaleghi, Sayed Mohammad Shafiee, Shiva Valaee, Zahra Ghanei, Abbas Jamshidizad, Mojtaba Dashtizad, Mehdi Shamsara
Summary: The study demonstrated that metformin can inhibit EMT behavior and HOTAIR expression in breast cancer cells, resulting in decreased cell migration and invasion, and modulation of the expression levels of related genes. Additionally, metformin also altered the promoter methylation pattern of the HOTAIR gene.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Review
Oncology
Laura Amicone, Alessandra Marchetti, Carla Cicchini
Summary: Epithelial-to-mesenchymal transition (EMT) is a cell differentiation process that gives epithelial cells the ability to move and invade, and its abnormal reactivation in cancer cells is crucial for metastasis. EMT is a dynamic program with various states, and the inverse transition, mesenchymal-to-epithelial transition (MET), is important for colonization of distant sites. Long non-coding RNAs (lncRNAs), specifically HOTAIR, play a critical role in regulating epithelial cell plasticity and EMT in tumors. This review focuses on the molecular mechanisms of HOTAIR expression and its functions in gene regulation and protein activities, as well as the challenges of targeting HOTAIR for therapeutic approaches against EMT.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Endocrinology & Metabolism
Hongqin Xiang, Luling Qiu, Wenqian Meng, Liangying Wang
Summary: Shikonin reduces the multiplication and metastasis of PTX-resistant CC cells and stimulates apoptosis. These effects may be related to the inhibition of HOTAIR and modulation of the Akt signal pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Developmental Biology
Tiffany L. Dill, Alina Carroll, Amanda Pinheiro, Jiachen Gao, Francisco J. Naya
Summary: The long noncoding RNA Meg3 plays a crucial role in regulating EMT, affecting myoblast differentiation and skeletal muscle regeneration. Inhibition of Meg3 induces EMT and suppresses cell state transitions, highlighting its key role in promoting differentiation of myoblasts. The study also demonstrates that Meg3-dependent Ezh2 activity impacts epigenetic alterations associated with TGF beta activation, providing insights into the mechanisms of muscle development.
Article
Biochemistry & Molecular Biology
Shuai Yang, Hui Li, Haipei Yao, Yao Zhang, Huiqian Bao, Liangjing Wu, Conghui Zhang, Min Li, Le Feng, Jingfa Zhang, Zhi Zheng, Guotong Xu, Fang Wang
Summary: The study revealed that lncRNA ERLR plays a role in TGF-beta 1-induced EMT in human RPE cells and is involved in the pathogenesis of PVR, providing new insights into the mechanism and treatment of the disease.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Qun Zhao, Xinran Cheng, Jian Guo, Yun Bi, Li Kuang, Jianhua Ren, Jing Zhong, Longrui Pan, Xudong Zhang, Yang Guo, Yongqiang Liu, Shu Jin, Yan Tan, Xianjun Yu
Summary: MLKL plays a suppressive role in intestinal tumorigenesis by inhibiting the IL-6/JAK2/STAT3 signaling pathway, reducing the risk of intestinal tumor development.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yonghe Li, Yaolin Yin, Yi He, Kun He, Jingdong Li
Summary: This study investigated the influence of son of sevenless homolog 1 (SOS1) on invasion and metastasis of hepatocellular carcinoma (HCC) cells. High expression of SOS1 was observed in most human liver cancers, indicating a worse prognosis. Knockout of SOS1 significantly decreased cell invasion and migration, inhibited the epithelial-mesenchymal transition (EMT), and suppressed the PI3K/AKT/mTOR pathway. These findings suggest that SOS1 may play a role in promoting invasion, migration, and metastasis of HCC cells through the activation of the PI3K/AKT/mTOR pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Rebekah Brooks, Judith Monzy, Bailey Aaron, Xue Zhang, Andrew Kossenkov, James Hayden, Frederick Keeney, David W. Speicher, Lin Zhang, Chi V. Dang
Summary: We identified ADIRF-AS1 as a circadian long non-coding RNA (lncRNA) that interacts with all components of the PBAF complex. ADIRF-AS1 partially regulates specific genes through modulation of PBAF and is associated with survival in human ccRCC.
Article
Pharmacology & Pharmacy
Pritha Dasgupta, Priyanka Kulkarni, Nadeem S. Bhat, Shahana Majid, Marisa Shiina, Varahram Shahryari, Soichiro Yamamura, Yuichiro Tanaka, Ravi Kumar Gupta, Rajvir Dahiya, Yutaka Hashimoto
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Cell Biology
Pritha Dasgupta, Priyanka Kulkarni, Shahana Majid, Yutaka Hashimoto, Marisa Shiina, Varahram Shahryari, Nadeem S. Bhat, Laura Tabatabai, Soichiro Yamamura, Sharanjot Saini, Yuichiro Tanaka, Rajvir Dahiya
CELL DEATH & DISEASE
(2020)
Article
Pharmacology & Pharmacy
Priyanka Kulkarni, Pritha Dasgupta, Nadeem S. Bhat, Yutaka Hashimoto, Sharanjot Saini, Varahram Shahryari, Soichiro Yamamura, Marisa Shiina, Yuichiro Tanaka, Rajvir Dahiya, Shahana Majid
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Oncology
Mohammed Soutto, Nadeem Bhat, Shayan Khalafi, Shoumin Zhu, Julio Poveda, Monica Garcia-Buitrago, Alexander Zaika, Wael El-Rifai
Summary: This study revealed that H. pylori infection can activate NF-kB and STAT3 to promote gastric cancer, with TFF1 acting as a suppressor of NF-kB activity and inflammatory response induced by H. pylori.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Kannappan Sriramajayam, Dunfa Peng, Heng Lu, Shoumin Zhou, Nadeem Bhat, Oliver G. McDonald, Jianwen Que, Alexander Zaika, Wael El-Rifai
Summary: The study showed that APE1 plays a critical role in regulating cellular responses to reflux conditions by protecting against oxidative damage and controlling NRF2 expression. APE1 is required for NRF2 stabilization, nuclear localization, and transcription activation in esophageal adenocarcinoma cells, contributing to cell survival under oxidative reflux conditions.
Article
Gastroenterology & Hepatology
Longlong Cao, Shoumin Zhu, Heng Lu, Mohammed Soutto, Nadeem Bhat, Zheng Chen, Dunfa Peng, Jianxian Lin, Jun Lu, Ping Li, Chaohui Zheng, Changming Huang, Wael El-Rifai
Summary: H. pylori infection induced the expression of RASAL2 through NF-kappa B, promoting beta-catenin activity. RASAL2 inhibited protein phosphatase 2A activity, activating the AKT/beta-catenin signaling axis.
Article
Gastroenterology & Hepatology
Xing Zhang, Mohammed Soutto, Zheng Chen, Nadeem Bhat, Shoumin Zhu, Moritz F. Eissmann, Matthias Ernst, Heng Lu, Dunfa Peng, Zekuan Xu, Wael El-Rifai
Summary: This study reveals the link between H pylori infection, inflammation, and FGFR4 activation, and identifies the important role of FGFR4 in gastric cancer development. The activation loop between FGFR4 and STAT3, mediated by steroid receptor coactivator, protects against H pylori-induced DNA damage and cell death.
Meeting Abstract
Oncology
Nadeem S. Bhat, Mohammed Soutto, Xing Zhang, Zheng Chen, Shoumin Zhu, Heng Lu, Dunfa Peng, Zekuan Xu, Wael El-Rifai
Meeting Abstract
Oncology
Nadeem S. Bhat, Mohammed Soutto, Xing Zhang, Zheng Chen, Shoumin Zhu, Heng Lu, Dunfa Peng, Zekuan Xu, Wael El-Rifai
Meeting Abstract
Gastroenterology & Hepatology
Ahmed R. Gomaa, Zheng Chen, Mohammed Soutto, Shoumin Zhu, Nadeem S. Bhat, Wael El-Rifai
Meeting Abstract
Gastroenterology & Hepatology
Mohammed Soutto, Nadeem S. Bhat, Shayan Khalafi, Shoumin Zhu, Julio Poveda, Monica Garcia-Buitrago, Alexander Zaika, Wael El-Rifai
Meeting Abstract
Gastroenterology & Hepatology
Shayan Khalafi, Shoumin Zhu, Mohammed Soutto, Nadeem S. Bhat, Wael El-Rifai
Meeting Abstract
Gastroenterology & Hepatology
Ahmed R. Gomaa, Zheng Chen, Mohammed Soutto, Nadeem S. Bhat, Shoumin Zhu, Wael El-Rifai
Meeting Abstract
Gastroenterology & Hepatology
Mohammed Soutto, Nadeem S. Bhat, Shoumin Zhu, Gomaa R. Ahmed, Zheng Chen, Dunfa Peng, Julio Poveda, Richard M. Peek, Wael El-Rifai