Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models

(2017) Nicolas Malmanche et al.   Scientific Reports

Activation of Cell Cycle Proteins in Transgenic Mice in Response to Neuronal Loss but not Amyloid-β and Tau Pathology

(2017) Joao P. Lopes et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death

(2016) Anne-Laure Bougé et al.   Disease Models & Mechanisms

Traumatic Brain Injury Causes Aberrant Migration of Adult-Born Neurons in the Hippocampus

(2016) Sara Ibrahim et al.   Scientific Reports

Regional mosaic genomic heterogeneity in the elderly and in Alzheimer’s disease as a correlate of neuronal vulnerability

(2015) Thomas Arendt et al.   ACTA NEUROPATHOLOGICA

Role of Trisomy 21 Mosaicism in Sporadic and Familial Alzheimer's Disease

(2015) Huntington Potter et al.   Current Alzheimer Research

Striatal astrocytes transdifferentiate into functional mature neurons following ischemic brain injury

(2015) Chun-Ling Duan et al.   GLIA

Neuroinflammatory Gene Regulation, Mitochondrial Function, Oxidative Stress, and Brain Lipid Modifications With Disease Progression in Tau P301S Transgenic Mice as a Model of Frontotemporal Lobar Degeneration-Tau

(2015) Irene López-González et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Aneuploidy in Lewy body diseases

(2015) Yue Yang et al.   NEUROBIOLOGY OF AGING

Aneuploidy: implications for protein homeostasis and disease

(2014) A. B. Oromendia et al.   Disease Models & Mechanisms

Continuous Postnatal Neurogenesis Contributes to Formation of the Olfactory Bulb Neural Circuits and Flexible Olfactory Associative Learning

(2014) M. Sakamoto et al.   JOURNAL OF NEUROSCIENCE

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

(2014) J. P. Magnusson et al.   SCIENCE

X chromosome aneuploidy in the Alzheimer’s disease brain

(2014) Yuri B Yurov et al.   Molecular Cytogenetics

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Amyloid-  signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease

(2013) M. E. Seward et al.   JOURNAL OF CELL SCIENCE

Mutations in MAPT give rise to aneuploidy in animal models of tauopathy

(2013) Giacomina Rossi et al.   NEUROGENETICS

Mitotic Spindle Defects and Chromosome Mis-Segregation Induced by LDL/Cholesterol—Implications for Niemann-Pick C1, Alzheimer’s Disease, and Atherosclerosis

(2013) Antoneta Granic et al.   PLoS One

Mosaic Copy Number Variation in Human Neurons

(2013) M. J. McConnell et al.   SCIENCE

Changes in neuronal DNA content variation in the human brain during aging

(2012) Hans-Georg Fischer et al.   AGING CELL

Cell Cycle Activation and Aneuploid Neurons in Alzheimer's Disease

(2012) Thomas Arendt   MOLECULAR NEUROBIOLOGY

Advances in understanding the molecular basis of frontotemporal dementia

(2012) Rosa Rademakers et al.   Nature Reviews Neurology

Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors

(2011) Sergiy I. Borysov et al.   CELL CYCLE

Neurogenesis in Adult Human Brain after Traumatic Brain Injury

(2011) WeiMing Zheng et al.   JOURNAL OF NEUROTRAUMA

Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes

(2011) Monique Judge et al.   Molecular Neurodegeneration

Selective Cell Death of Hyperploid Neurons in Alzheimer’s Disease

(2010) Thomas Arendt et al.   AMERICAN JOURNAL OF PATHOLOGY

A new function of microtubule-associated protein tau: Involvement in chromosome stability

(2010) Giacomina Rossi et al.   CELL CYCLE

Ontogenetic Variation of the Human Genome

(2010) Y. Yurov et al.   CURRENT GENOMICS

Neuronal Aneuploidy in Health and Disease:A Cytomic Approach to Understand the Molecular Individuality of Neurons

(2009) Thomas Arendt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alzheimer Aβ Peptide Induces Chromosome Mis-Segregation and Aneuploidy, Including Trisomy 21: Requirement for Tau and APP

(2009) Antoneta Granic et al.   MOLECULAR BIOLOGY OF THE CELL

Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: Differential expression and pathological meaning

(2009) Ivan Y. Iourov et al.   NEUROBIOLOGY OF DISEASE

GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny

(2009) Yuri B Yurov et al.   Molecular Cytogenetics

Different fibrillar Aβ 1–42 concentrations induce adult hippocampal neurons to reenter various phases of the cell cycle

(2008) Shohreh Majd et al.   BRAIN RESEARCH

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance

(2008) Yoshiteru Kai et al.   CELL RESEARCH

Apoptotic cell death, long-term persistence, and neuronal differentiation of aneuploid cells generated in the adult brain of teleost fish

(2008) R. Samuel Rajendran et al.   Developmental Neurobiology

Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy

(2006) Debrah I. Boeras et al.   NEUROBIOLOGY OF AGING