Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway

The Major Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate, Inhibits Obesity, Metabolic Syndrome, and Fatty Liver Disease in High-Fat–Fed Mice

(2018) Mousumi Bose et al.   JOURNAL OF NUTRITION

A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2

(2017) Yujie Li et al.   HEPATOLOGY

FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain

(2017) Han Yan et al.   Molecular Medicine Reports

Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass

(2016) Masaki Funamoto et al.   ANNALS OF THORACIC SURGERY

SIRT1 is a critical regulator of K562 cell growth, survival, and differentiation

(2016) Mark T. Duncan et al.   EXPERIMENTAL CELL RESEARCH

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

SREBP2 Activation Induces Hepatic Long-chain Acyl-CoA Synthetase 1 (ACSL1) Expressionin Vivoandin Vitrothrough a Sterol Regulatory Element (SRE) Motif of the ACSL1 C-promoter

(2016) Amar Bahadur Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk factors and subtypes of acute ischemic stroke. A study at King Fahd Hospital of the University

(2016) Azra Zafar et al.   Neurosciences

Hyperlipidemia in Early Adulthood Increases Long-Term Risk of Coronary Heart Disease

(2015) A. M. Navar-Boggan et al.   CIRCULATION

SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway

(2015) C. C. S. Chini et al.   CLINICAL CANCER RESEARCH

MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4

(2015) Kai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigallocatechin gallate potentially attenuates Fluoride induced oxidative stress mediated cardiotoxicity and dyslipidemia in rats

(2015) S. Miltonprabu et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake

(2015) Jonathan W. Haskins et al.   Science Signaling

Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion

(2015) Yuting Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake

(2015) Jonathan W. Haskins et al.   Science Signaling

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis

(2014) Kyoung-Jin Oh et al.   BMB Reports

Treatment of Non-Alcoholic Fatty Liver Disease

(2014) Jessica Dyson et al.   DIGESTIVE DISEASES

EGCG Attenuates Autoimmune Arthritis by Inhibition of STAT3 and HIF-1α with Th17/Treg Control

(2014) Eun-Ji Yang et al.   PLoS One

Therapeutic potential of EGCG on acute renal damage in a rat model of obstructive nephropathy

(2013) PING ZHOU et al.   Molecular Medicine Reports

FoxO1 Inhibits Sterol Regulatory Element-binding Protein-1c (SREBP-1c) Gene Expression via Transcription Factors Sp1 and SREBP-1c

(2012) Xiong Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective effect of (–)-epigallocatechin-3-gallate in rats when administered pre- or post-traumatic brain injury

(2012) Tatsuki Itoh et al.   JOURNAL OF NEURAL TRANSMISSION

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

(2012) Zheng Sun et al.   NATURE MEDICINE

Hyperlipidemia as a Risk Factor for Cardiovascular Disease

(2012) Robert H. Nelson   PRIMARY CARE

Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications

(2011) Brahma N. Singh et al.   BIOCHEMICAL PHARMACOLOGY

FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes

(2011) Shin Tsunekawa et al.   DIABETES

Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo

(2010) Phan LCHB Tran et al.   BMC CANCER

EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling

(2010) Hsiu-Chung Ou et al.   JOURNAL OF APPLIED PHYSIOLOGY

DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1

(2010) Xiumei Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SREBPs: protein interaction and SREBPs

(2008) Ryuichiro Sato   FEBS Journal

Epigallocatechin Gallate, a Green Tea Phytochemical, Attenuates Alcohol-Induced Hepatic Protein and Lipid Damage

(2008) S. Kaviarasan et al.   TOXICOLOGY MECHANISMS AND METHODS