A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2

Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2

(2015) Meghan F. Hogan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis

(2015) Yongfeng Song et al.   JOURNAL OF HEPATOLOGY

The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1

(2015) Jinbo Han et al.   NATURE

PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus

(2015) Daqian Xu et al.   Nature Communications

CRTC2 activation in the suprachiasmatic nucleus, but not paraventricular nucleus, varies in a diurnal fashion and increases with nighttime light exposure

(2014) Julie A. Highland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

SIK2 Is Critical in the Regulation of Lipid Homeostasis and Adipogenesis In Vivo

(2014) Jinyoung Park et al.   DIABETES

Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6

(2013) Rongya Tao et al.   JOURNAL OF LIPID RESEARCH

A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products

(2012) James R. Krycer et al.   BIOCHEMICAL JOURNAL

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner

(2012) Rachel Tanos et al.   HEPATOLOGY

FoxO1 Inhibits Sterol Regulatory Element-binding Protein-1c (SREBP-1c) Gene Expression via Transcription Factors Sp1 and SREBP-1c

(2012) Xiong Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Hepatic Suppression ofFoxo1andFoxo3Causes Hypoglycemia and Hyperlipidemia in Mice

(2011) Kebin Zhang et al.   ENDOCRINOLOGY

Nuclear receptors in liver disease

(2011) Martin Wagner et al.   HEPATOLOGY

Sterol metabolism and SREBP activation

(2010) Ryuichiro Sato   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis

(2010) Tiangang Li et al.   HEPATOLOGY

Hepatic FoxO1 Ablation Exacerbates Lipid Abnormalities during Hyperglycemia

(2010) Rebecca A. Haeusler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity

(2010) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes

(2009) Maziyar Saberi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Control of ACAT2 Liver Expression by HNF4α

(2009) C. Pramfalk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TORC2, a Coactivator of cAMP-response Element-binding Protein, Promotes Epstein-Barr Virus Reactivation from Latency through Interaction with Viral BZLF1 Protein

(2009) Takayuki Murata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Enhances Post-translational Processing of Nascent SREBP-1c by Promoting Its Phosphorylation and Association with COPII Vesicles

(2009) Chandrahasa R. Yellaturu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism

(2008) Laura Calpe-Berdiel et al.   ATHEROSCLEROSIS

Hepatic insulin resistance directly promotes formation of cholesterol gallstones

(2008) Sudha B Biddinger et al.   NATURE MEDICINE