PI3K–Akt signaling controls PFKFB3 expression during human T-lymphocyte activation

TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells

(2017) Ana Rodríguez-García et al.   FEBS Journal

Lymphocyte surface molecules as immune activation biomarkers

(2016) Eberhard Wieland et al.   CLINICAL BIOCHEMISTRY

Akt mediates TIGAR induction in HeLa cells following PFKFB3 inhibition

(2016) Helga Simon-Molas et al.   FEBS LETTERS

Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation

(2016) Hung D. Nguyen et al.   JOURNAL OF CLINICAL INVESTIGATION

PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense

(2016) Hui Jiang et al.   JOURNAL OF IMMUNOLOGY

Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia

(2016) Peter J. Siska et al.   JOURNAL OF IMMUNOLOGY

Emerging concepts of T cell metabolism as a target of immunotherapy

(2016) Chih-Hao Chang et al.   NATURE IMMUNOLOGY

HIF-1  and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages

(2015) A. Tawakol et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions

(2015) Kathrin Renner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway

(2015) Sophie Trefely et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR and metabolic regulation of conventional and regulatory T cells

(2015) Chaohong Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metabolism of activated T lymphocytes

(2014) Jason A Maciolek et al.   CURRENT OPINION IN IMMUNOLOGY

Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells

(2014) Samik Basu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

(2013) Laura Novellasdemunt et al.   BIOCHEMICAL JOURNAL

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Dendritic cells phenotype fitting under hypoxia or lipopolysaccharide; adenosine 5′-triphosphate-binding cassette transporters far beyond an efflux pump

(2013) N. Lloberas et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation

(2012) Sucheta Telang et al.   Journal of Translational Medicine

Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells

(2011) Laura Novellasdemunt et al.   BIOCHEMICAL JOURNAL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Cooperation of Adenosine with Macrophage Toll-4 Receptor Agonists Leads to Increased Glycolytic Flux through the Enhanced Expression ofPFKFB3Gene

(2011) Almudena Ruiz-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Glucose Metabolism in Stimulated T Lymphocytes Is Regulated by Mitogen-Activated Protein Kinase Signaling

(2010) Aimee J. Marko et al.   PLoS One

Interleukin 6 Enhances Glycolysis through Expression of the Glycolytic Enzymes Hexokinase 2 and 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase-3

(2010) Masaru Ando et al.   JOURNAL OF NIPPON MEDICAL SCHOOL

Pfkfb3is transcriptionally upregulated in diabetic mouse liver through proliferative signals

(2009) Joan Duran et al.   FEBS Journal