Multicenter double-blind randomized controlled trial to evaluate the effectiveness and safety of bortezomib as a treatment for refractory systemic lupus erythematosus

The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus

(2015) Tobias Alexander et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-DNA antibodies — quintessential biomarkers of SLE

(2015) David S. Pisetsky   Nature Reviews Rheumatology

Bortezomib Plus Continuous B Cell Depletion Results in Sustained Plasma Cell Depletion and Amelioration of Lupus Nephritis in NZB/W F1 Mice

(2015) Laleh Khodadadi et al.   PLoS One

A pathogenic role for ER stress-induced autophagy and ER chaperone GRP78/BiP in T lymphocyte systemic lupus erythematosus

(2014) Won-Seok Lee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bortezomib therapy-related lung disease in Japanese patients with multiple myeloma: Incidence, mortality and clinical characterization

(2013) Kazutake Yoshizawa et al.   CANCER SCIENCE

Bone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: Implications for the treatment of autoimmunity

(2012) Imtiaz M. Mumtaz et al.   JOURNAL OF AUTOIMMUNITY

Proteasome inhibitor-based therapy for antibody-mediated rejection

(2012) R. Carlin Walsh et al.   KIDNEY INTERNATIONAL

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Successful use of bortezomib in a patient with systemic lupus erythematosus and multiple myeloma

(2010) K. Frohlich et al.   ANNALS OF THE RHEUMATIC DISEASES

The Endoplasmic Reticulum Stress-Inducible Protein, Herp, Is a Potential Triggering Antigen for Anti-DNA Response

(2010) Y. Hirabayashi et al.   JOURNAL OF IMMUNOLOGY

The Role of Ubiquitin in NF-κB Regulatory Pathways

(2009) Brian Skaug et al.   Annual Review of Biochemistry

Infections as triggers and complications of systemic lupus erythematosus

(2008) A Doria et al.   AUTOIMMUNITY REVIEWS

Lupus: improving long-term prognosis

(2008) A Doria et al.   LUPUS

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

(2008) Kirsten Neubert et al.   NATURE MEDICINE

Proteasome inhibition: a new therapeutic option in lupus nephritis?

(2008) J. van der Vlag et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bortezomib Provides Effective Therapy for Antibody- and Cell-Mediated Acute Rejection

(2008) Matthew J. Everly et al.   TRANSPLANTATION