Determining the fate of hepatic cells by lineage tracing: Facts and pitfalls

Ablation of Foxl1-Cre–Labeled Hepatic Progenitor Cells and Their Descendants Impairs Recovery of Mice From Liver Injury

(2015) Soona Shin et al.   GASTROENTEROLOGY

Hepatocytes, Rather than Cholangiocytes, Can Be the Major Source of Primitive Ductules in the Chronically Injured Mouse Liver

(2014) Sayaka Sekiya et al.   AMERICAN JOURNAL OF PATHOLOGY

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

(2014) Kilangsungla Yanger et al.   Cell Stem Cell

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

(2014) Branden D. Tarlow et al.   Cell Stem Cell

Clonal tracing of Sox9+liver progenitors in mouse oval cell injury

(2014) Branden D. Tarlow et al.   HEPATOLOGY

The biliary epithelium gives rise to liver progenitor cells

(2014) Daniel Rodrigo-Torres et al.   HEPATOLOGY

Sry HMG Box Protein 9-positive (Sox9+) Epithelial Cell Adhesion Molecule-negative (EpCAM−) Biphenotypic Cells Derived from Hepatocytes Are Involved in Mouse Liver Regeneration

(2014) Naoki Tanimizu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury

(2014) Johanna R. Schaub et al.   Cell Reports

KDR Identifies a Conserved Human and Murine Hepatic Progenitor and Instructs Early Liver Development

(2013) Orit Goldman et al.   Cell Stem Cell

Extensive Conversion of Hepatic Biliary Epithelial Cells to Hepatocytes After Near Total Loss of Hepatocytes in Zebrafish

(2013) Tae–Young Choi et al.   GASTROENTEROLOGY

Regeneration of Liver After Extreme Hepatocyte Loss Occurs Mainly via Biliary Transdifferentiation in Zebrafish

(2013) Jianbo He et al.   GASTROENTEROLOGY

Robust cellular reprogramming occurs spontaneously during liver regeneration

(2013) K. Yanger et al.   GENES & DEVELOPMENT

PTEN loss and KRAS activation cooperate in murine biliary tract malignancies

(2013) Victoria Marsh et al.   JOURNAL OF PATHOLOGY

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury

(2013) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice

(2012) Regina Español–Suñer et al.   GASTROENTEROLOGY

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Embryonic Ductal Plate Cells Give Rise to Cholangiocytes, Periportal Hepatocytes, and Adult Liver Progenitor Cells

(2011) Rodolphe Carpentier et al.   GASTROENTEROLOGY

Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential

(2011) S. Shin et al.   GENES & DEVELOPMENT

Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice

(2011) Sonya V. Iverson et al.   HEPATOLOGY

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

(2011) Yann Malato et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Labeling Does Not Detect Epithelial-to-Mesenchymal Transition of Cholangiocytes in Liver Fibrosis in Mice

(2010) David Scholten et al.   GASTROENTEROLOGY

Genetic lineage tracing, a powerful tool to investigate the embryonic organogenesis and adult organ maintenance of the pancreas

(2010) Yoshiya Kawaguchi et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

(2010) C. H. Osterreicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The histogenesis of regenerative nodules in human liver cirrhosis

(2009) Wey-Ran Lin et al.   HEPATOLOGY

Foxl1 is a marker of bipotential hepatic progenitor cells in mice

(2008) Sara D. Sackett et al.   HEPATOLOGY

Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development

(2008) Kinji Asahina et al.   HEPATOLOGY

Fate-Mapping Evidence That Hepatic Stellate Cells Are Epithelial Progenitors in Adult Mouse Livers

(2008) Liu Yang et al.   STEM CELLS