Article
Oncology
Swetlana Ladigan-Badura, Deepak B. Vangala, Christoph Engel, Karolin Bucksch, Robert Hueneburg, Claudia Perne, Jacob Nattermann, Verena Steinke-Lange, Nils Rahner, Hans K. Schackert, Juergen Weitz, Matthias Kloor, Judith Kuhlkamp, Huu Phuc Nguyen, Gabriela Moeslein, Christian Strassburg, Monika Morak, Elke Holinski-Feder, Reinhard Buettner, Stefan Aretz, Markus Loeffler, Wolff Schmiegel, Christian Pox, Karsten Schulmann
Summary: Regular upper GI endoscopy surveillance for LS patients starting from the age of 30 can successfully detect gastric cancer in early stages, leading to more frequent diagnoses in early-stage disease compared to symptomatic diagnoses. The study emphasizes the importance of early detection through regular screenings.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
James London, Juana Martin-Lopez, Inho Yang, Jiaquan Liu, Jong-Bong Lee, Richard Fishel
Summary: The study reveals that HsMSH2-HsMSH6 serves as a platform for the formation of a stable sliding clamp by HsMLH1-HsPMS2 on mismatched DNA. This mechanism solves an operational puzzle in MMR and can predict the distribution of clinically relevant HsMLH1 missense mutations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Deepak B. Vangala, Swetlana Ladigan-Badura, Christoph Engel, Robert Hueneburg, Claudia Perne, Karolin Bucksch, Jacob Nattermann, Verena Steinke-Lange, Nils Rahner, Juergen Weitz, Matthias Kloor, Judith Tomann, Ali Canbay, Huu-Phuc Nguyen, Christian Strassburg, Gabriele Moeslein, Monika Morak, Elke Holinski-Feder, Reinhard Buettner, Stefan Aretz, Markus Loeffler, Wolff Schmiegel, Christian Pox, Karsten Schulmann
Summary: Early detection of duodenal cancer (DC) through esophago-gastro-duodenoscopy (EGD) in Lynch syndrome (LS) patients is feasible, with a higher rate in the surveillance group. Despite factors like family history and genetic mutations, a significant proportion of patients can benefit from early detection through surveillance.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medical Laboratory Technology
Ashley Scheiderer, Courtney Riedinger, Kristopher Kimball, Larry Kilgore, Amila Orucevic
Summary: This study found that Lynch syndrome germline mutation can be detected in endometrial carcinoma patients whose tumors display sole subclonal mismatch repair protein staining. The results emphasize the importance of reporting subclonal staining patterns to ensure appropriate clinical follow-up.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Article
Oncology
Po-Kuei Hsu, Yi-Chen Yeh, Ling- Chien, Chien-Sheng Huang, Han-Shui Hsu
Summary: Pathologic complete lymph node regression may be an indicator of sensitivity to neoadjuvant treatment and serves as a good prognostic factor in patients with esophageal squamous cell carcinoma.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Guillaume Perrod, Gabriel Rahmi, Christophe Cellier
Summary: Lynch syndrome is a hereditary predisposition to colorectal cancer, and regular colonoscopies with high definition screening can reduce the incidence and mortality of colorectal cancer, recommended to start at the age of 20-25.
DIGESTIVE ENDOSCOPY
(2021)
Article
Surgery
Boris Janssen, Stijn van Roessel, Susan van Dieren, Onno de Boer, Volkan Adsay, Olca Basturk, Lodewijk Brosens, Fiona Campbell, Deyali Chatterjee, Angela Chou, Claudio Doglioni, Irene Esposito, Roger Feakins, Talia L. Fuchs, Noriyoshi Fukushima, Anthony J. Gill, Seung-Mo Hong, Ralph H. Hruban, Jeffrey Kaplan, Alyssa Krasinkas, Claudio Luchini, Chanjuan Shi, Aatur Singhi, Elizabeth Thompson, Marie-Louise F. Velthuysen, Marc G. Besselink, Joanne Verheij, Huamin Wang, Caroline Verbeke, Arantza Farina
Summary: The ISGPP-1 study found that it is unreliable to identify the effect of neoadjuvant therapy in resected pancreatic cancer, and the interobserver agreement for current tumour response scoring systems is suboptimal.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Oncology
J. F. Huisman, I. J. H. Schoenaker, R. M. Brohet, O. Reerink, H. van der Sluis, F. C. P. Moll, E. de Boer, J. C. de Graaf, W. H. de Vos tot Nederveen Cappel, G. L. Beets, H. L. van Westreenen
Summary: The study demonstrates that the introduction of structured multidisciplinary response evaluation leads to a significant decrease in patients with locally advanced rectal cancer achieving complete response after nCRT, reducing the need for surgery and improving stoma-free survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Khaled M. Madbouly, Sameh Hany Emile, Yasmine Amr Issa
Summary: Compared to sporadic rectal cancer, rectal cancer in patients with HNPCC shows poorer response to neoadjuvant chemoradiation, leading to higher local recurrence and lower overall survival. Tumor regression is less common in HNPCC patients, and none of them achieve complete response.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Pathology
Anne-Sophie van der Werf-'t, Diantha Terlouw, Carli M. Tops, Merel S. van Kan, Liselotte P. van Hest, Hans J. P. Gille, Floor A. M. Duijkers, Anja Wagner, Ellis L. Eikenboom, Tom G. W. Letteboer, Mirjam M. de Jong, Sanne W. Bajwa-ten Broeke, Fonnet E. Bleeker, Encarna B. Gomez Garcia, Niels de Wind, J. Tom van Wezel, Hans Morreau, Manon Suerink, Maartje Nielsen
Summary: This study aimed to identify the various causes of the discordant phenotypes in MSH6-associated Lynch syndrome, including abnormal immunohistochemical staining and mutations in the mismatch repair genes. The results suggest that genetic analysis should be considered in colorectal cancer patients with a strong family history.
Article
Oncology
Anne E. O'Shea, Phillip M. Kemp Bohan, Elizabeth L. Carpenter, Patrick M. McCarthy, Alexandra M. Adams, Robert C. Chick, Julia O. Bader, Robert W. Krell, George E. Peoples, Guy T. Clifton, Daniel W. Nelson, Timothy J. Vreeland
Summary: Downstaging after neoadjuvant therapies improves survival in patients with localized pancreatic adenocarcinoma. The addition of radiation therapy may increase the rate of downstaging without affecting overall oncologic outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Joana Lemos Garcia, Isadora Rosa, Sofia Saraiva, Ines Marques, Ricardo Fonseca, Pedro Lage, Ines Francisco, Patricia Silva, Bruno Filipe, Cristina Albuquerque, Isabel Claro
Summary: Recognition of hereditary colorectal cancer (CRC) syndrome is crucial, and Lynch Syndrome (LS) is the most frequent immunohistochemistry (IHC)-screening for mismatch repair proteins (MMR) deficiency in CRC. An unicentric cohort study was conducted in a central Oncological Hospital to assess its results. Routine immunohistochemistry screening for MMR protein deficiency in CRC patients under 70 years-old identified Lynch Syndrome patients that could be missed using restrictive criteria. These results highlight the importance of universal CRC screening for MMR protein status.
Article
Oncology
Andressa Dias Costa, Sara A. Vayrynen, Akhil Chawla, Jinming Zhang, Juha P. Vayrynen, Mai Chan Lau, Hannah L. Williams, Chen Yuan, Vicente Morales-Oyarvide, Dalia Elganainy, Harshabad Singh, James M. Cleary, Kimberly Perez, Kimmie Ng, William Freed-Pastor, Joseph D. Mancias, Stephanie K. Dougan, Jiping Wang, Douglas A. Rubinson, Richard F. Dunne, Margaret M. Kozak, Lauren Brais, Emma Reilly, Thomas Clancy, David C. Linehan, Daniel T. Chang, Aram F. Hezel, Albert C. Koong, Andrew J. Aguirre, Brian M. Wolpin, Jonathan A. Nowak
Summary: This study investigates the impact of neoadjuvant chemotherapy on the tumor immune microenvironment in pancreatic ductal adenocarcinoma. The findings suggest that neoadjuvant chemotherapy can shift the immune microenvironment towards an anti-tumorigenic state and improve patient survival.
CLINICAL CANCER RESEARCH
(2022)
Article
Engineering, Biomedical
Noriaki Hashimoto, Kaho Ko, Tatsuya Yokota, Kei Kohno, Masato Nakaguro, Shigeo Nakamura, Ichiro Takeuchi, Hidekata Hontani
Summary: This study proposes a method that quantitatively evaluates the typicality of H&E-stained tissue slides using IHC staining patterns, and applies this typicality to select instances for constructing classifiers to predict the subtype of malignant lymphoma. The results show that instance selection based on typicality can improve the generalization ability of the classifier.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2022)
Article
Oncology
Robyn D. Gartrell, Thomas Enzler, Pan S. Kim, Benjamin T. Fullerton, Ladan Fazlollahi, Andrew X. Chen, Hanna E. Minns, Subha Perni, Stuart P. Weisberg, Emanuelle M. Rizk, Samuel Wang, Eun Jeong Oh, Xinzheng Guo, Codruta Chiuzan, Gulam A. Manji, Susan E. Bates, John Chabot, Beth Schrope, Michael Kluger, Jean Emond, Raul Rabadan, Donna Farber, Helen E. Remotti, David P. Horowitz, Yvonne M. Saenger
Summary: Despite complete surgical resection and intense systemic therapies, patients with pancreatic ductal adenocarcinoma (PDAC) have a poor prognosis. Immunotherapies have almost uniformly failed in the treatment of PDAC. This study found that while chemoradiation therapy (CRT) can achieve high T cell densities in PDAC compared to melanoma, the phenotype and spatial organization of T cells may limit the benefit of T cell infiltration in this immunotherapy-resistant tumor.
Article
Pathology
Alex Vilkin, Ya'ara Leibovici-Weissman, Marisa Halpern, Sara Morgenstern, Eli Brazovski, Rachel Gingold-Belfer, Nir Wasserberg, Baruch Brenner, Yaron Niv, Orly Sneh-Arbib, Zohar Levi
Article
Oncology
Hagit N. Baris, Inbal Barnes-Kedar, Helen Toledano, Marisa Halpern, Dov Hershkovitz, Alexander Lossos, Israela Lerer, Tamar Peretz, Revital Kariv, Shlomi Cohen, Elizabeth E. Half, Nurit Magal, Valerie Drasinover, Katharina Wimmer, Yael Goldberg, Dani Bercovich, Zohar Levi
PEDIATRIC BLOOD & CANCER
(2016)
Article
Gastroenterology & Hepatology
Yaron Niv, Ram Dickman, Zohar Levi, Gadi Neumann, Dorit Ehrlich, Haim Bitterman, Jacob Dreiher, Arnon Cohen, Doron Comaneshter, Eyran Halpern
WORLD JOURNAL OF GASTROENTEROLOGY
(2015)
Article
Oncology
Zohar Levi, Jeremy D. Kark, Ari Shamiss, Estela Derazne, Dorit Tzur, Lital Keinan-Boker, Irena Liphshitz, Yaron Niv, Moshe Furman, Arnon Afek
Article
Genetics & Heredity
Z. Levi, R. Kariv, I. Barnes-Kedar, Y. Goldberg, E. Half, S. Morgentern, B. Eli, H. N. Baris, A. Vilkin, R. G. Belfer, Y. Niv, R. Elhasid, R. Dvir, N. Abu-Freha, S. Cohen
Article
Genetics & Heredity
Y. Goldberg, I. Barnes-Kedar, I. Lerer, N. Halpern, M. Plesser, A. Hubert, L. Kadouri, H. Goldshmidt, I. Solar, H. Strul, G. Rosner, H. N. Baris, T. Peretz, Z. Levi, R. Kariv
Correction
Gastroenterology & Hepatology
Yaron Niv, Doron Boltin, Marisa Halpern, Miriam Cohen, Zohar Levi, Alex Vilkin, Sara Morgenstern, Vahig Manugian, Erica St Lawrence, Pascal Gagneux, Surinder K. Batra, Samuel B. Ho
DIGESTIVE DISEASES AND SCIENCES
(2013)
Article
Gastroenterology & Hepatology
Doron Boltin, Rachel Gingold-Belfer, Ram Dickman, Marisa Halpern, Sara Morgenstern, Miri Roth, Olga Layfer, Alex Vilkin, Yaron Niv, Zohar Levi
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2014)
Article
Gastroenterology & Hepatology
Doron Boltin, Rachel Gingold-Belfer, Lev Lichtenstein, Zohar Levi, Yaron Niv
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2014)
Article
Oncology
Yael Goldberg, Inbal Kedar, Revital Kariiv, Naama Halpern, Morasha Plesser, Ayala Hubert, Luna Kaduri, Michal Sagi, Israela Lerer, Dvorah Abeliovich, Tamar Hamburger, Aviram Nissan, Hanoch Goldshmidt, Irit Solar, Ravit Geva, Hana Strul, Guy Rosner, Hagit Baris, Zohar Levi, Tamar Peretz
Article
Gastroenterology & Hepatology
Zohar Levi, Ari Shamiss, Gerald M. Fraser, Moshe Furman, Estela Derazne, Dorit Tzur, Barak Gordon, Sara Welinsky, Rachel Gingold Belfer, Arnon Afek
INFLAMMATORY BOWEL DISEASES
(2013)
Article
Gastroenterology & Hepatology
Yaron Niv, Doron Boltin, Marisa Halpern, Miriam Cohen, Zohar Levi, Alex Vilkin, Sara Morgenstern, Vahig Manugian, Erica St Lawrence, Pascal Gagneux, Sukhwinder Kaur, Poonam Sharma, Surinder K. Batra, Samuel B. Ho
WORLD JOURNAL OF GASTROENTEROLOGY
(2014)
Article
Biotechnology & Applied Microbiology
Ayelet Harari, Revital Abecassis, Noa Relevi, Zohar Levi, Ami Ben-Amotz, Yehuda Kamari, Dror Harats, Aviv Shaish
BIOMED RESEARCH INTERNATIONAL
(2013)
Article
Biotechnology & Applied Microbiology
Annat Raiter, Alexander Vilkin, Rachel Gingold, Zohar Levi, Marisa Halpern, Yaron Niv, Britta Hardy
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
(2014)