Article
Gastroenterology & Hepatology
Joana Alves da Silva, Daniela Falcao, Luis Maia, Tiago Pereira Guedes, Monica Garrido, Maria Ines Novo, Marta Rocha, Pedro Pinto, Teresa Moreira, Jose Manuel Ferreira, Isabel Pedroto
Summary: This study evaluated the adherence of acute variceal bleeding patients to recommended care and found a high adherence rate which significantly impacted outcomes. The results suggest that this model of care provides accessibility and equity in urgent endoscopy services.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Nicolas M. Intagliata, Robert S. Rahimi, Fatima Higuera-de-la-Tijera, Douglas A. Simonetto, Alberto Queiroz Farias, Daniel F. Mazo, Justin R. Boike, Jonathan G. Stine, Marina Serper, Gustavo Pereira, Angelo Z. Mattos, Sebastian Marciano, Jessica P. E. Davis, Carlos Benitez, Ryan Chadha, Nahum Mendez-Sanchez, Andrew S. deLemos, Arpan Mohanty, Melisa Dirchwolf, Brett E. Fortune, Patrick G. Northup, James T. Patrie, Stephen H. Caldwell
Summary: Procedural-related bleeding occurs rarely in hospitalized patients with cirrhosis. It is associated with high-risk procedures, higher Model for End-Stage Liver Disease score, and elevated body mass index (BMI). However, it is not associated with conventional hemostasis tests, preprocedure prophylaxis, or recent antithrombotic therapy.
Article
Medicine, General & Internal
Aalam Sohal, Hunza Chaudhry, Armaan Dhaliwal, Piyush Singla, Gagan Gupta, Raghav Sharma, Dino Dukovic, Devang Prajapati
Summary: Gender differences have an impact on outcomes in hospitalizations related to esophageal variceal bleeding. Women hospitalized with esophageal variceal bleeding have a lower risk of death and are less likely to receive TIPS treatment.
ANNALS OF MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Angelo Zullo, Marco Soncini, Cristina Bucci, Riccardo Marmo
Summary: The study found that the overall mortality rate in cirrhotics with UGIB seems to be decreasing, and the value did not differ significantly between variceal and nonvariceal types. Prevention of hepatorenal syndrome and hepatic encephalopathy, along with implementation of antibiotic prophylaxis, could potentially improve survival in these patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Surgery
Siyu Jiang, Xiaoquan Huang, Liyuan Ni, Ruiqi Xia, Kiyoko Nakayama, Shiyao Chen
Summary: The study found that splenectomy prior to endoscopic treatment leads to a better long-term survival rate for patients with schistosomiasis-induced variceal bleeding, although it also increases the risk of portal vein thrombosis and decreases the proportion of severe ascites.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Haiyu Wang, Biao Wen, Xianyi Chang, Qiaoping Wu, Weiqun Wen, Fuyuan Zhou, Yabing Guo, Yali Ji, Yixiu Gu, Qintao Lai, Qinjun He, Junying Li, Jinjun Chen, Jinlin Hou
Summary: This study validates the excellent performance of the combination of spleen stiffness measurement (cut-off 46 kPa) with Baveno VI criteria in ruling out high-risk varices in patients with HBV-related cirrhosis under maintained viral suppression. The combined model is able to safely rule out high-risk varices (missed/total < 5%) and spare over half of esophagogastroduodenoscopy procedures.
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Javier Martinez, Virginia Hernandez-Gea, Enrique Rodriguez-de-Santiago, Luis Tellez, Bogdan Procopet, Alvaro Giraldez, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Luis Ibanez-Samaniego, Gilberto Silva-Junior, Joan Genesca, Christophe Bureau, Jonel Trebicka, Rafael Banares, Aleksander Krag, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise L. Gluud, Carlos Noronha-Ferreira, Nuria Canete, Manuel Rodriguez, Arnulf Ferlitsch, Remy Schwarzer, Jose Luis Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'Era, Marco Senzolo, Juan G. Abraldes, Manuel Romero-Gomez, Alexander Zipprich, Meritxell Casas, Helena Masnoun, Massimo Primignani, Frederik Nevens, Jose Luis Calleja, Christian Jansen, Marie Angele Robic, Irene Conejo, Maria Vega Catalina, Marika Rudler, Edilmar Alvarado, Valeria Perez-Campuzano, Maria Anna Guardascione, Petra Fischer, Jaime Bosch, Juan Carlos Garcia-Pagan, Agustin Albillos
Summary: Despite antibiotic prophylaxis, nearly 20% of patients with acute variceal bleeding develop bacterial infections during hospitalization. Respiratory bacterial infections are the most common, occurring early after admission. Respiratory infection is associated with advanced liver disease, severe hepatic encephalopathy, and the use of nasogastric tube, orotracheal intubation for endoscopy, or esophageal balloon tamponade.
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ares Villagrasa, Virginia Hernandez-Gea, Ramon Bataller, Alvaro Giraldez, Bogdan Procopet, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Luis Ibanez-Samaniego, Agustin Albillos, Christophe Bureau, Jonel Trebicka, Elba Llop, Wim Laleman, J. M. Palazon, Jose Castellote, Susana L. Rodrigues, Lise N. Gluud, Carlos Ferreira, Nuria Canete, Manuel Rodriguez, Arnulf L. Ferlitsch, Jose Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'Era, Marco G. Senzolo, Juan Abraldes, Alexander Zipprich, Meritxell Casas, Helena Masnou, Massimo Primignani, Aleksander Krag, Gilberto Silva-Junior, Manuel Romero-Gomez, Marcel A. Tantau, Maria Guardascione, Edilmar Alvarado, Marika Rudler, Rafael Banares, Javier A. Martinez, Marie Robic, Christian L. Jansen, Jose Calleja, Frederik Nevens, Jaime Bosch, Meritxell C. Ventura-Cots, Juan Garcia-Pagan, Joan Genesca
Summary: This study aimed to assess the prevalence of alcohol-related hepatitis (AH) in patients with variceal bleeding and compare the clinical outcomes of AH patients with other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. The results showed that AH patients had more complications and abstinent ALD patients had higher survival rates compared to other groups.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Marika Rudler, Virginia Hernandez-Gea, Bogdan Dumitru Procopet, Alvaro Giraldez, Lucio Amitrano, Candid Villanueva, Luis Ibanez, Gilberto Silva-Junior, Joan Genesca, Christophe Bureau, Jonel Trebicka, Rafael Banares, Aleksander Krag, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise Lotte Gluud, Carlos Noronha Ferreira, Nouria Canete, Manuel Rodriguez, Arnulf Ferlitsch, Jose Luis Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'era, Marco Senzolo, Juan G. Abraldes, Manuel Romero-Gomez, Alexander Zipprich, Meritxell Casas, Helena Masnou, Helene Larrue, Massimo Primignani, Frederik Nevens, Jose Luis Calleja, Remy Schwarzer, Christian Jansen, Marie-Angele Robic, Irene Conejo, Javier Martinez Gonzalez, Maria Vega Catalina, Agustin Albillos, Edilmar Alvarado, Maria Anna Guardascione, Maxime Mallet, Simona Tripon, Georgina Casanovas, Jaume Bosch, Juan-Carlos Garcia-Pagan, Dominique Thabut
Summary: pTIPS is more effective in improving survival compared to endoscopic treatment for high-risk patients with cirrhosis and variceal bleeding. HE at admission does not affect the efficacy of pTIPS.
Article
Health Care Sciences & Services
Jing Wang, Zhengqiang Wang, Mingkai Chen, Yong Xiao, Shi Chen, Lianlian Wu, Liwen Yao, Xiaoda Jiang, Jiao Li, Ming Xu, Mengjuan Lin, Yijie Zhu, Renquan Luo, Chenxia Zhang, Xun Li, Honggang Yu
Summary: Bleeding risk factors for gastroesophageal varices (GEV) detected by endoscopy in cirrhotic patients determine the prophylactical treatment patients will undergo in the following 2 years. We propose a methodology for measuring the risk factors. We create an artificial intelligence system (ENDOANGEL-GEV) containing six models to segment GEV and to classify the grades (grades 1-3) and red color signs (RC, RC0-RC3) of varices. It also summarizes changes in the above results with region in real time. ENDOANGEL-GEV is trained using 6034 images from 1156 cirrhotic patients across three hospitals (dataset 1) and validated on multicenter datasets with 11009 images from 141 videos (dataset 2) and in a prospective study recruiting 161 cirrhotic patients from Renmin Hospital of Wuhan University (dataset 3). In dataset 1, ENDOANGEL-GEV achieves intersection over union values of 0.8087 for segmenting esophageal varices and 0.8141 for gastric varices. In dataset 2, the system maintains fairly accuracy across images from three hospitals. In dataset 3, ENDOANGEL-GEV surpasses attended endoscopists in detecting RC of GEV and classifying grades (p < 0.001). When ranking the risk of patients combined with the Child-Pugh score, ENDOANGEL-GEV outperforms endoscopists for esophageal varices (p < 0.001) and shows comparable performance for gastric varices (p = 0.152). Compared with endoscopists, ENDOANGEL-GEV may help 12.31% (16/130) more patients receive the right intervention. We establish an interpretable system for the endoscopic diagnosis and risk stratification of GEV. It will assist in detecting the first bleeding risk factors accurately and expanding the scope of quantitative measurement of diseases.
NPJ DIGITAL MEDICINE
(2022)
Article
Medicine, General & Internal
Kaini Wu, Yunfeng Fu, Zixiang Guo, Xiaodong Zhou
Summary: This study aimed to investigate the correlation between the timing of endoscopy and clinical outcomes in cirrhotic patients with esophagogastric variceal bleeding (EGVB), as well as to analyze the risk factors for composite outcomes after endoscopic treatment. The results showed that the 30-day rebleeding rate was significantly higher in patients who underwent endoscopic treatment within 12 hours compared to those treated beyond 12 hours, but there was no significant difference in 30-day mortality.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Yong Lv, Wei Bai, Xuan Zhu, Hui Xue, Jianbo Zhao, Yuzheng Zhuge, Junhui Sun, Chunqing Zhang, Pengxu Ding, Zaibo Jiang, Xiaoli Zhu, Weixin Ren, Yingchun Kewei LiZhang, Wenguang Zhang, Kai Li, Zhengyu Wang, Bohan Luo, Xiaomei Li, Jie Yuan, Zhiping Yang, Wengang Guo, Dongdong Xia, Huahong Xie, Changbing Yang, Yanglin Pan, Zhanxin Yin, Daiming Fan, Guohong Han
Summary: This study aimed to assess the impact of portal vein thrombosis (PVT) on the outcomes of cirrhotic patients with acute variceal bleeding (AVB). The results showed that, compared to patients without PVT, patients with PVT had a similar risk of mortality, further bleeding, and new or worsening ascites after standard treatment.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Min Wei, Yong Chen, Minghui Wang, Jinhou Li, Yunqing Zeng, Xin Sun, Anzhong Zhang, Xiaofeng Liu, Tao Zhou, Yanjing Gao
Summary: This study compared the efficacy of partial splenic embolization (PSE) combined with endoscopic therapy versus endoscopic therapy alone in cirrhosis patients with acute variceal bleeding (AVB) and hypersplenism. The results showed that the rates of variceal re-bleeding and recurrence were significantly lower in the combined treatment group. Furthermore, peripheral blood counts and liver function improved significantly in the combined treatment group.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Jae Heon Kim, Chang Bin Im, Sang Soo Lee, Hankyu Jeon, Jung Woo Choi, Hee Jin Kim, Ra Ri Cha, Hyun Chin Cho, Jae Min Lee, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung, Ok-Jae Lee
Summary: This study evaluated the incidence of acute kidney injury (AKI) using International Club of Ascites (ICA) criteria in cirrhotic patients with acute variceal bleeding (AVB) and found that the presence of AKI is a predictor of mortality in these patients.
BMC GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Thomas Horvatits, Nadim Mahmud, Marina Serper, Oliver Seiz, Dominik Reher, Andreas Drolz, Naveed Sarnast, Wenyi Gu, Hans Peter Erasmus, Gabriel Allo, Phillip Ferstl, Sebastian Wittmann, Felix Piecha, Stefan Groth, Stefan Zeuzem, Christoph Schramm, Samuel Huber, Thomas Rosch, Ansgar W. Lohse, Jonel Trebicka, Gerald Ogola, Sumeet K. Asrani, Johannes Kluwe
Summary: MELD-LA significantly improves the predictive performance of short-term mortality associated with variceal bleeding and might represent a useful marker for risk assessment and therapeutic intervention in patients with this condition.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Infectious Diseases
Georges-Philippe Pageaux, Clovis Lusivika Nzinga, Nathalie Ganne, Didier Samuel, Celine Dorival, Fabien Zoulim, Carole Cagnot, Thomas Decaens, Dominique Thabut, Tarik Asselah, Philippe Mathurin, Francois Habersetzer, Jean-Pierre Bronowicki, Dominique Guyader, Isabelle Rosa, Vincent Leroy, Olivier Chazouilleres, Victor de Ledinghen, Marc Bourliere, Xavier Causse, Paul Cales, Sophie Metivier, Veronique Loustaud-Ratti, Ghassan Riachi, Laurent Alric, Moana Gelu-Simeon, Anne Minello, Jerome Gournay, Claire Geist, Albert Tran, Armand Abergel, Isabelle Portal, Louis d'Alteroche, Francois Raffi, Helene Fontaine, Fabrice Carrat, Stanislas Pol
Summary: Treatment with direct antiviral agents is associated with reduced risk for mortality. The sustained virological response rate is 88%. Therefore, direct antiviral agents should be considered for any patient with HCV-related decompensated cirrhosis.
BMC INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
Isabelle Ollivier-Hourmand, Yohann Repesse, Pierre Nahon, Cendrine Chaffaut, Thong Dao, Thi Thu Nga Nguyen, Patrick Marcellin, Dominique Roulot, Victor De Ledinghen, Stanislas Pol, Dominique Guyader, Isabelle Archambeaud, Fabien Zoulim, Frederic Oberti, Albert Tran, Jean-Pierre Bronowicki, Louis D'Alteroche, Denis Ouzan, Jean-Marie Peron, Jean-Pierre Zarski, Marc Bourliere, Dominique Larrey, Alexandre Louvet, Paul Cales, Armand Abergel, Philippe Mathurin, Ariane Mallat, Jean-Frederic Blanc, Eric Nguyen-Khac, Ghassan Riachi, Laurent Alric, Lawrence Serfaty, Teresa Antonini, Christophe Moreno, Pierre Attali, Dominique Thabut, Christophe Pilette, Jean-Didier Grange, Christine Silvain, Nicolas Carbonell, Brigitte Bernard-Chabert, Odile Goria, Claire Wartelle, Romain Moirand, Christos Christidis, Gabriel Perlemuter, Violaine Ozenne, Jean Henrion, Sophie Hillaire, Vincent Di Martino, Xavier Amiot, Angela Sutton, Nathalie Barget, Sylvie Chevret, Nathalie Ganne-Carrie
Summary: The study indicates that non-O blood type does not influence the disease outcome, disease progression, or overall survival in Child-Pugh A cirrhotic patients.
LIVER INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Oumarou Nabi, Jerome Boursier, Nathanael Lapidus, Philippe Mathurin, Victor de Ledinghen, Jean-Michel Petit, Marcel Goldberg, Marie Zins, Karine Lacombe, Lawrence Serfaty
Summary: This study evaluates the characteristics of non-alcoholic fatty liver disease (NAFLD) and its impact on morbidity and mortality in type 2 diabetic subjects in a community setting. The results show that diabetes significantly increases the risk of NAFLD and advanced fibrosis in diabetic patients. Furthermore, the presence of NAFLD in diabetic subjects is associated with an increased risk of severe liver-related events, cardiovascular disease, and overall mortality. The severity of fibrosis also correlates with an increased risk of hepatic and extrahepatic complications. These findings provide real-world evidence of the clinical and economic burden of NAFLD in diabetic subjects.
LIVER INTERNATIONAL
(2022)
Correction
Gastroenterology & Hepatology
D. Morales-Arraez, M. Ventura-Cots, J. Altamirano, J. G. Abraldes, M. Cruz-Lemini, M. R. Thursz, S. R. Atkinson, S. K. Sarin, W. Kim, R. Chavez-Araujo, M. F. de la Tijera, A. K. Singal, V. H. Shah, P. S. Kamath, A. Duarte-Rojo, E. A. Charles, V. Vargas, M. Jager, P. E. Rautou, D. Rincon, F. Zamarripa, J. C. Restrepo-Gutierrez, A. Torre, M. R. Lucey, J. P. Arab, P. Mathurin, A. Louvet, G. Garcia-Tsao, J. A. Gonzalez, E. C. Verna, R. S. Brown, J. Argemi, C. Fernandez-Carrillo, A. Clemente, E. Alvarado-Tapias, E. Forrest, M. Allison, R. Bataller
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Line Carolle Ntandja Wandji, Massih Ningarhari, Elise Lemaitre, Marion Khaldi, Pierre Saffers, Julien Lollivier, Guillaume Lassailly, Sebastien Dharancy, Philippe Mathurin, Alexandre Louvet
Summary: Severe alcohol-related hepatitis patients with lung infection at admission had lower probability of receiving steroids compared to other infections and noninfected patients. Lung infection and nonresponse to steroids were independently associated with 3-month mortality after steroid initiation, highlighting the importance of specific management for lung infection during severe AH.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Letter
Gastroenterology & Hepatology
Francois Pattou, Guillaume Lasailly, Violeta Raverdy, Robert Caiazzo, Philippe Mathurin
Letter
Gastroenterology & Hepatology
Coralie Amadou, Oumarou Nabi, Lawrence Serfaty, Karine Lacombe, Jerome Boursier, Philippe Mathurin, Celine Ribet, Victor de Ledinghen, Marie Zins, Marie-Aline Charles
Review
Gastroenterology & Hepatology
Daniel Q. Huang, Philippe Mathurin, Helena Cortez-Pinto, Rohit Loomba
Summary: Global alcohol consumption has increased, leading to a rise in the incidence of alcohol-associated cirrhosis and hepatocellular carcinoma. Heavy alcohol consumption is a major cause of morbidity and mortality. Measures are needed to reduce the burden of alcohol-related liver diseases.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Surgery
Kate Minoux, Guillaume Lassailly, Massih Ningarhari, Henri Lubret, Medhi El Amrani, Valerie Canva, Stephanie Truant, Philippe Mathurin, Alexandre Louvet, Gilles Lebuffe, Odile Goria, Eric Nguyen-Khac, Emmanuel Boleslawski, Sebastien Dharancy
Summary: This study investigated the trajectory of HCC patients awaiting liver transplantation who were treated with sorafenib. The results suggest that patients treated for HCC progression have high dropout rates and low survival rates, while patients treated for impossibility of loco-regional therapy have acceptable survival rates.
TRANSPLANT INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Massih Ningarhari, Abbas Mourad, Claire Delacote, Line-Carolle Ntandja Wandji, Guillaume Lassailly, Alexandre Louvet, Sebastien Dharancy, Philippe Mathurin, Sylvie Deuffic-Burban
Summary: This study evaluates the effects of hepatocellular carcinoma (HCC) screening on case fatality rates (CFRs) and cancer-specific mortality in patients with cirrhosis using a modeling approach. The results indicate that six-month ultrasound (US) screening can reduce the 10-year HCC-CFR, and shorter US intervals or the use of MRI can further decrease HCC-related mortality and overall mortality.
HEPATOLOGY COMMUNICATIONS
(2022)
Letter
Gastroenterology & Hepatology
Philippe Mathurin, Sebastien Dharancy, Alexandre Louvet
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Claire Delacote, Line Carolle Ntandja Wandji, Alexandre Louvet, Pierre Bauvin, Guillaume Lassailly, Massih Ningarhari, Sebastien Dharancy, Philippe Mathurin, Sylvie Deuffic-Burban
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Claire Delacote, Line Carolle Ntandja Wandji, Alexandre Louvet, Pierre Bauvin, Guillaume Lassailly, Massih Ningarhari, Sebastien Dharancy, Guillaume Clement, Amelie Bruandet, Xavier Lenne, Philippe Mathurin, Sylvie Deuffic-Burban
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Massih Ningarhari, Abbas Mourad, Claire Delacote, Line Carolle Ntandja Wandji, Guillaume Lassailly, Alexandre Louvet, Sebastien Dharancy, Philippe Mathurin, Sylvie Deuffic-Burban
JOURNAL OF HEPATOLOGY
(2022)