Review
Gastroenterology & Hepatology
Nidhi Jalan-Sakrikar, Teresa Brevini, Robert C. Huebert, Fotios Sampaziotis
Summary: The burden of liver diseases is increasing worldwide, and liver transplantation is the only treatment option. Regenerative medicine aims to repair or replace damaged liver tissue with healthy functional cells, offering potential therapeutic benefits. Liver organoids provide an optimal source of cells for regenerative medicine and offer new insights into liver physiology.
Review
Gastroenterology & Hepatology
Barath Jagadisan, Anil Dhawan
Summary: The etiology of liver diseases in children varies by age and may have significant consequences if not diagnosed and managed promptly. This article covers 5 clinical scenarios including infant liver disease, acute liver failure, bleeding varices, metabolic disorders, and liver tumors/trauma, emphasizing the importance of early diagnosis and appropriate management. Various conditions can cause liver disease in infants, often presenting as conjugated jaundice, requiring algorithmic testing for accurate diagnosis and timely treatment to prevent mortality and long-term morbidity.
JOURNAL OF HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Scott L. L. Friedman, Arun J. J. Sanyal
Summary: The field of hepatology has made significant progress in understanding liver function, genetic determinants of disease, antiviral therapy, and transplantation in the past 75 years. However, challenges such as fatty liver diseases, autoimmune disease, cancer, and pediatric liver disease still need to be addressed. Diagnostic advances are urgently needed to improve risk stratification and testing of new agents. Integrated care models should be extended to address systemic manifestations and comorbidities. Expansion of the workforce and incorporating emerging skills in data management and precision medicine are necessary. Continued investment in science is crucial for further progress.
Review
Gastroenterology & Hepatology
Elliot B. Tapper, Marina Serper, David S. Goldberg
Summary: Patients with chronic liver disease can benefit from pragmatic trial designs, which aim to provide evidence for the adoption of interventions in real-world clinical practice. The efficiency of identifying, recruiting, and following patients, the resemblance of interventions and design to usual clinical care, and the importance of outcomes to patients are key factors in determining the pragmatism of a trial. This review focuses on the promise, trade-offs, and purpose of pragmatic trials in hepatology.
Article
Gastroenterology & Hepatology
Joern M. Schattenberg, Naga Chalasani, Naim Alkhouri
Summary: In the past 20 years, hepatology has experienced major developments in diagnostic tools, prognostic models, and treatment options, making it one of the most complex medical subspecialties. Artificial intelligence (AI) and machine learning have enabled computers to learn from clinical datasets and solve medical problems better than physicians in certain areas. AI algorithms are being implemented in liver imaging, interpretation of liver histopathology, noninvasive tests, and prediction models in hepatology.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Joan A. Culpepper-Morgan, Alexandra Guillaume, Jeremy Louissaint, Renee Williams
Summary: The viewpoint discusses the members' routes into gastroenterology and hepatology, the promotion of inclusivity and equity in academia and medicine, and advice to Black students interested in a career in science or medicine.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Dingzhi Wang, Carlos S. Cabalag, Nicholas J. Clemons, Raymond N. DuBois
Summary: The cyclooxygenase-2-prostaglandin E2 pathway plays an important role in the development of gastrointestinal cancer, promoting tumor growth and affecting host defenses. Overcoming tumor immune evasion is a major challenge in cancer immunotherapy.
Review
Gastroenterology & Hepatology
Alireza Lorzadeh, Maile Romero-Wolf, Ajay Goel, Unmesh Jadhav
Summary: Mutational defects and epigenetic regulation play crucial roles in diseases like colorectal cancer and inflammatory bowel diseases. The interplay of epigenetic features, such as polycomb repressive complex 2-mediated trimethylation of lysine 27 on histone 3 and DNA methylation, are important in these diseases, but molecular details are still lacking. This review also discusses other epigenetic mechanisms relevant to gastrointestinal cancers and the current understanding of chromatin control in the pathogenesis of inflammatory bowel diseases.
Editorial Material
Gastroenterology & Hepatology
Naima Amrani
Summary: As the first woman to serve as the president of the World Gastroenterology Organisation, I have the chance to reflect on the place of women in gastroenterology and assess the progress we have made and the challenges still ahead of us.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tung-Hung Su, Chih-Horng Wu, Jia-Horng Kao
Summary: Artificial intelligence, machine learning, and deep learning are revolutionizing the field of hepatology by providing precise predictive models for disease diagnosis, monitoring, and prognosis. Despite the vast potential of AI applications, challenges such as data preparation, quality, biases, algorithm selection, evaluation, and validation must be addressed to fully realize the benefits of AI in healthcare.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Editorial Material
Chemistry, Applied
Andrew Teasdale, Kevin Hughes
Summary: This article primarily discusses two specific areas. First, it examines the revision of ICH Q2(R1) and the development of ICH Q14, which have reached the key ICH milestone of Step 2 publication for public consultation. Second, it discusses the evolving and critical area of the environmental impact of the pharmaceutical industry, particularly focusing on the impact of solvent use and the necessity to reduce barriers for recycling and reuse in order to decrease reliance on virgin solvents. It explores how guidance on quality can affect this and emphasizes the need for a more holistic approach to recycling.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Review
Gastroenterology & Hepatology
Tiffany Wu, Douglas A. Simonetto, John D. Halamka, Vijay H. Shah
Summary: Innovative digital health technologies are revolutionizing healthcare, enabling personalized and patient-centric approaches that extend beyond traditional facilities into patients' homes and daily lives. These digital solutions can monitor physiological data, predict disease progression, and facilitate disease intervention through accessible telemedicine and mobile health options.
Article
Chemistry, Applied
Andrew Teasdale, Phil J. Borman, Alexander K. Mullen
Summary: This edition focuses on the revision of ICH Q2(R1) and the development of ICH Q14, which have reached the significant milestone of Step 2 publication for public consultation. It also examines the environmental impact of the pharmaceutical industry, particularly the impact of solvent use and the need to reduce barriers to recycling and reuse. The article emphasizes the role of quality guidance and the importance of adopting a holistic approach to recycling.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Editorial Material
Gastroenterology & Hepatology
Patrizia Burra, Alberto Zanetto, Giacomo Germani
Summary: Biological sex bias is a common issue in clinical trials, including fields such as gastroenterology and hepatology. Lack of sex parity and attention to sex-specific analyses hinder the translation of trial results into real-world clinical practice, leading to unpredictable consequences for patient care.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Ji-Qiao Liu, Jia-Yu Ren, Xiao-Lan Xu, Li-Yan Xiong, Yue-Xiang Peng, Xiao-Fang Pan, Christoph F. Dietrich, Xin-Wu Cui
Summary: Artificial intelligence (AI), especially deep learning, has gained attention for its performance in medical image analysis. It can help doctors make more accurate diagnoses by automatically assessing complex medical images. AI based on ultrasound has shown promising results in analyzing liver diseases and gastrointestinal conditions, such as predicting the severity of fatty liver and identifying benign and malignant liver lesions. It has also been applied in detecting pancreatic cancer and predicting tumor deposits in rectal cancer using endoscopic ultrasonography. This review focuses on the technical knowledge and clinical applications of AI in ultrasound of liver and gastroenterology diseases, as well as discusses the challenges and future perspectives of AI.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
