Anticonvulsive effects of endocannabinoids; an investigation to determine the role of regulatory components of endocannabinoid metabolism in the Pentylenetetrazol induced tonic- clonic seizures

Cannabinoid receptor 1/2 double-knockout mice develop epilepsy

(2017) Shane Rowley et al.   EPILEPSIA

Cannabis and epilepsy: An ancient treatment returns to the fore

(2017) Ethan B. Russo   EPILEPSY & BEHAVIOR

Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures

(2016) Yuki Sugaya et al.   Cell Reports

Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice

(2015) E.L. von Rüden et al.   NEUROBIOLOGY OF DISEASE

Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis

(2015) Jie Wen et al.   NEUROPHARMACOLOGY

Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation

(2015) Erin M. Rock et al.   PSYCHOPHARMACOLOGY

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

(2015) Guy Griebel et al.   Scientific Reports

Disease-Modifying Effects of RHC80267 and JZL184 in a Pilocarpine Mouse Model of Temporal Lobe Epilepsy

(2014) Lei Ma et al.   CNS Neuroscience & Therapeutics

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

(2014) Orrin Devinsky et al.   EPILEPSIA

Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting

(2014) Filomena Fezza et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice

(2014) Alipi V. Naydenov et al.   NEURON

Modulation of Pilocarpine-Induced Seizures by Cannabinoid Receptor 1

(2014) Rebecca L. Kow et al.   PLoS One

Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1receptor-independent mechanism

(2013) T D M Hill et al.   BRITISH JOURNAL OF PHARMACOLOGY

Piperazine and Piperidine Triazole Ureas as Ultrapotent and Highly Selective Inhibitors of Monoacylglycerol Lipase

(2013) Niina Aaltonen et al.   CHEMISTRY & BIOLOGY

CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations

(2013) Rita Citraro et al.   EPILEPSY RESEARCH

Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism

(2013) Katarzyna Starowicz et al.   PLoS One

CB1 receptor activation in the nucleus accumbens core impairs contextual fear learning

(2012) Rodrigo Pedroza-Llinás et al.   BEHAVIOURAL BRAIN RESEARCH

High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes

(2012) Jochen Schwenk et al.   NEURON

Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy

(2012) Rita Citraro et al.   NEUROPHARMACOLOGY

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

(2011) J. R. Savinainen et al.   Acta Physiologica

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

(2011) Wolfgang Löscher   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Novel selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models

(2010) Wei Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus

(2010) Andrés E Chávez et al.   NATURE NEUROSCIENCE

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

(2010) William R Marrs et al.   NATURE NEUROSCIENCE

Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus

(2010) A. Ludányi et al.   NEUROSCIENCE

Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy

(2009) Robert E. Blair et al.   NEUROPHARMACOLOGY

Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats

(2009) Alexa A. Wakley et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

(2008) Heather S. Hoover et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms

(2008) S Maione et al.   BRITISH JOURNAL OF PHARMACOLOGY

The global burden and stigma of epilepsy

(2008) Hanneke M. de Boer et al.   EPILEPSY & BEHAVIOR

Targeting the endocannabinoid system: to enhance or reduce?

(2008) Vincenzo Di Marzo   NATURE REVIEWS DRUG DISCOVERY