The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response

Mechanisms governing inflammasome activation, assembly and pyroptosis induction

(2017) Sannula Kesavardhana et al.   INTERNATIONAL IMMUNOLOGY

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β

(2017) Benjamin Weichand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation

(2017) Catherine Olesch et al.   MEDIATORS OF INFLAMMATION

Glycosphingolipids on Human Myeloid Cells Stabilize E-Selectin–Dependent Rolling in the Multistep Leukocyte Adhesion CascadeSignificance

(2016) Nandini Mondal et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline

(2016) Constantin Adams et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Implication of matrix metalloproteinases 2 and 9 in ceramide 1-phosphate-stimulated macrophage migration

(2016) Marta Ordoñez et al.   CELLULAR SIGNALLING

Starvation-Induced Stress Response Is Critically Impacted by Ceramide Levels in Caenorhabditis elegans

(2016) Mingxue Cui et al.   GENETICS

Lipid rafts in immune signalling: current progress and future perspective

(2016) Pallavi Varshney et al.   IMMUNOLOGY

C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-κB Activation in Neutrophils

(2016) Kristin Baudiß et al.   JOURNAL OF IMMUNOLOGY

Nuclear Lipids in the Nervous System: What they do in Health and Disease

(2016) Mercedes Garcia-Gil et al.   NEUROCHEMICAL RESEARCH

The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells

(2016) Mateusz Adamiak et al.   Stem Cell Reviews and Reports

Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system

(2016) K Wang et al.   Cell Death & Disease

Instigation of NLRP3 inflammasome activation and glomerular injury in mice on the high fat diet: role of acid sphingomyelinase gene

(2016) Krishna M. Boini et al.   Oncotarget

Starvation-Induced Stress Response Is Critically Impacted by Ceramide Levels in Caenorhabditis elegans

(2016) Mingxue Cui et al.   GENETICS

The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells

(2016) Mateusz Adamiak et al.   Stem Cell Reviews and Reports

Liposomal C6 Ceramide Activates Protein Phosphatase 1 to Inhibit Melanoma Cells

(2016) Fangzhen Jiang et al.   PLoS One

Role of lipid microdomains in TLR-mediated signalling

(2015) Jean-Marie Ruysschaert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils

(2015) Julia Barthelmes et al.   BRAIN BEHAVIOR AND IMMUNITY

LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme

(2015) Mohammad Ali et al.   FEBS LETTERS

Properties and functions of lactosylceramide from mouse neutrophils

(2015) K. Iwabuchi et al.   GLYCOBIOLOGY

Macrophage-specificde NovoSynthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity

(2015) Christina D. Camell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis

(2015) Huiming Peng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans

(2015) Kazuhisa Iwabuchi et al.   MEDIATORS OF INFLAMMATION

Very-long-chain fatty acid sphingomyelin in nuclear lipid microdomains of hepatocytes and hepatoma cells: can the exchange from C24:0 to C16:0 affect signal proteins and vitamin D receptor?

(2015) Andrea Lazzarini et al.   MOLECULAR BIOLOGY OF THE CELL

Serum deprivation alters lipid profile in HN9.10e embryonic hippocampal cells

(2015) Mercedes Garcia-Gil et al.   NEUROSCIENCE LETTERS

Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation

(2015) Patrick S. Tawadros et al.   SHOCK

Regulation of the Inflammasome by Ceramide in Cystic Fibrosis Lungs

(2014) Heike Grassmé et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Nuclear Lipid Microdomain as Resting Place of Dexamethasone to Impair Cell Proliferation

(2014) Samuela Cataldi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration

(2013) Lide Arana et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

GSL-Enriched Membrane Microdomains in Innate Immune Responses

(2013) Hitoshi Nakayama et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Role of acid sphingomyelinase in the regulation of mast cell function

(2013) W. Yang et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase

(2013) Jennifer A. Mietla et al.   JOURNAL OF LIPID RESEARCH

Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

(2013) Dhirendra K. Simanshu et al.   NATURE

Impact of Sphingomyelin Synthase 1 Deficiency on Sphingolipid Metabolism and Atherosclerosis in Mice

(2012) Zhiqiang Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues

(2012) Krishna P. Bhabak et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ceramide kinase deficiency improves diet-induced obesity and insulin resistance

(2012) Susumu Mitsutake et al.   FEBS LETTERS

Ganglioside-binding specificities of E. coli enterotoxin LT-IIc: Importance of long-chain fatty acyl ceramide

(2012) C. S. Berenson et al.   GLYCOBIOLOGY

Ceramide and Toll-Like Receptor 4 Are Mobilized into Membrane Rafts in Response to Helicobacter pylori Infection in Gastric Epithelial Cells

(2012) Dah-Yuu Lu et al.   INFECTION AND IMMUNITY

Factor Associated with Neutral Sphingomyelinase Activity Mediates Navigational Capacity of Leukocytes Responding to Wounds and Infection: Live Imaging Studies in Zebrafish Larvae

(2012) A. Boecke et al.   JOURNAL OF IMMUNOLOGY

E-prostanoid 2 receptors dampen mast cell degranulation via cAMP/PKA-mediated suppression of IgE-dependent signaling

(2012) Mariona Serra-Pages et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis

(2012) DeAnna A. Baker et al.   RHEUMATOLOGY INTERNATIONAL

Intracellular Lipid Flux and Membrane Microdomains as Organizing Principles in Inflammatory Cell Signaling

(2011) M. B. Fessler et al.   JOURNAL OF IMMUNOLOGY

Nuclear lipid microdomains regulate nuclear vitamin D3 uptake and influence embryonic hippocampal cell differentiation

(2011) Elisa Bartoccini et al.   MOLECULAR BIOLOGY OF THE CELL

DC-SIGN Mediated Sphingomyelinase-Activation and Ceramide Generation Is Essential for Enhancement of Viral Uptake in Dendritic Cells

(2011) Elita Avota et al.   PLoS Pathogens

An Obligate Role for Membrane-Associated Neutral Sphingomyelinase Activity in Orienting Chemotactic Migration of Human Neutrophils

(2010) Robert G. Sitrin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Dihydrosphingomyelin Impairs HIV-1 Infection by Rigidifying Liquid-Ordered Membrane Domains

(2010) Catarina R. Vieira et al.   CHEMISTRY & BIOLOGY

Ceramide kinase is not essential but might act as an Ca2+-sensor for mast cell activation

(2010) Susumu Mitsutake et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Significance of glycosphingolipid fatty acid chain length on membrane microdomain-mediated signal transduction

(2009) Kazuhisa Iwabuchi et al.   FEBS LETTERS

Ceramide 1-Phosphate Is Required for the Translocation of Group IVA Cytosolic Phospholipase A2and Prostaglandin Synthesis

(2009) Nadia F. Lamour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Polarity Factor Par3 Binds SPTLC1 and Modulates Monocyte Serine Palmitoyltransferase Activity and Chemotaxis

(2009) Norimasa Tamehiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels

(2009) Dayanjan S. Wijesinghe et al.   JOURNAL OF LIPID RESEARCH

The nuclear ceramide/diacylglycerol balance depends on the physiological state of thyroid cells and changes during UV-C radiation-induced apoptosis

(2008) E. Albi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Sphingomyelin Synthase 2 Deficiency Attenuates NFκB Activation

(2008) Tiruneh K. Hailemariam et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate

(2008) C MAO   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions

(2008) C. A. Oskeritzian et al.   BLOOD

Ceramide 1-phosphate (C1P) promotes cell migration

(2008) María H. Granado et al.   CELLULAR SIGNALLING

Lipid Microdomains in Cell Nucleus

(2008) Giacomo Cascianelli et al.   MOLECULAR BIOLOGY OF THE CELL