Investigation of the role ofTCF4rare sequence variants in schizophrenia

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Large-scale genomics unveils the genetic architecture of psychiatric disorders

(2014) Jacob Gratten et al.   NATURE NEUROSCIENCE

Congenital erythrocytosis associated with gain-of-function HIF2A gene mutations and erythropoietin levels in the normal range

(2013) S. Perrotta et al.   HAEMATOLOGICA

Exome Sequencing Followed by Large-Scale Genotyping Suggests a Limited Role for Moderately Rare Risk Factors of Strong Effect in Schizophrenia

(2012) Anna C. Need et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rare, Low-Frequency, and Common Variants in the Protein-Coding Sequence of Biological Candidate Genes from GWASs Contribute to Risk of Rheumatoid Arthritis

(2012) Dorothée Diogo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TCF4(e2-2; ITF2): A schizophrenia-associated gene with pleiotropic effects on human disease

(2012) Katherinne Navarrete et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

A novel genetic variant in the transcription factor Islet-1 exerts gain of function on myocyte enhancer factor 2C promoter activity

(2012) Felix W. Friedrich et al.   EUROPEAN JOURNAL OF HEART FAILURE

Pitt–Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects

(2012) Mari Sepp et al.   HUMAN MOLECULAR GENETICS

Functional analysis ofTCF4missense mutations that cause Pitt-Hopkins syndrome

(2012) Marc Forrest et al.   HUMAN MUTATION

ALX4 gain-of-function mutations in nonsyndromic craniosynostosis

(2012) Garima Yagnik et al.   HUMAN MUTATION

The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants

(2012) B J Mowry et al.   MOLECULAR PSYCHIATRY

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

Exome sequencing and the genetic basis of complex traits

(2012) Adam Kiezun et al.   NATURE GENETICS

Differential confounding of rare and common variants in spatially structured populations

(2012) Iain Mathieson et al.   NATURE GENETICS

Genetic architectures of psychiatric disorders: the emerging picture and its implications

(2012) Patrick F. Sullivan et al.   NATURE REVIEWS GENETICS

Analysis of the VAV3 as Candidate Gene for Schizophrenia: Evidences From Voxel-Based Morphometry and Mutation Screening

(2012) Branko Aleksic et al.   SCHIZOPHRENIA BULLETIN

Genetic and functional analysis of the gene encoding neurogranin in schizophrenia

(2012) Yu-Chih Shen et al.   SCHIZOPHRENIA RESEARCH

An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People

(2012) M. R. Nelson et al.   SCIENCE

TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders

(2012) K V Wirgenes et al.   Translational Psychiatry

Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

(2011) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Comparison of statistical tests for disease association with rare variants

(2011) Saonli Basu et al.   GENETIC EPIDEMIOLOGY

Common variants at VRK2 and TCF4 conferring risk of schizophrenia

(2011) Stacy Steinberg et al.   HUMAN MOLECULAR GENETICS

Exome sequencing supports a de novo mutational paradigm for schizophrenia

(2011) Bin Xu et al.   NATURE GENETICS

Increased exonic de novo mutation rate in individuals with schizophrenia

(2011) Simon L Girard et al.   NATURE GENETICS

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

(2011) Manuel A Rivas et al.   NATURE GENETICS

Clustered Coding Variants in the Glutamate Receptor Complexes of Individuals with Schizophrenia and Bipolar Disorder

(2011) René A. W. Frank et al.   PLoS One

Functional Diversity of Human Basic Helix-Loop-Helix Transcription Factor TCF4 Isoforms Generated by Alternative 5′ Exon Usage and Splicing

(2011) Mari Sepp et al.   PLoS One

Sequencing of DISC1 Pathway Genes Reveals Increased Burden of Rare Missense Variants in Schizophrenia Patients from a Northern Swedish Population

(2011) Lotte N. Moens et al.   PLoS One

Demographic history and rare allele sharing among human populations

(2011) S. Gravel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADAMTSL3 as a candidate gene for schizophrenia: Gene sequencing and ultra-high density association analysis by imputation

(2011) David J. Dow et al.   SCHIZOPHRENIA RESEARCH

A New Testing Strategy to Identify Rare Variants with Either Risk or Protective Effect on Disease

(2011) Iuliana Ionita-Laza et al.   PLoS Genetics

Testing for an Unusual Distribution of Rare Variants

(2011) Benjamin M. Neale et al.   PLoS Genetics

Pooled Association Tests for Rare Variants in Exon-Resequencing Studies

(2010) Alkes L. Price et al.   AMERICAN JOURNAL OF HUMAN GENETICS

No evidence that rare coding variants in ZNF804A confer risk of schizophrenia

(2010) S. Dwyer et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Cognitive and Sensorimotor Gating Impairments in Transgenic Mice Overexpressing the Schizophrenia Susceptibility Gene Tcf4 in the Brain

(2010) Magdalena M. Brzózka et al.   BIOLOGICAL PSYCHIATRY

Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia

(2010) A Piton et al.   MOLECULAR PSYCHIATRY

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

(2010) Christopher T Johansen et al.   NATURE GENETICS

Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility

(2010) Itaru Kushima et al.   SCHIZOPHRENIA BULLETIN

TCF4, Schizophrenia, and Pitt-Hopkins Syndrome

(2010) D. J. Blake et al.   SCHIZOPHRENIA BULLETIN

Resequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia

(2010) Yu-Chih Shen et al.   SCHIZOPHRENIA RESEARCH

Genome-wide Association Study of Alcohol Dependence

(2009) Jens Treutlein et al.   ARCHIVES OF GENERAL PSYCHIATRY

A Genome-Wide Screen for Spatially Restricted Expression Patterns Identifies Transcription Factors That Regulate Glial Development

(2009) H. Fu et al.   JOURNAL OF NEUROSCIENCE

Discovery of Rare Variants via Sequencing: Implications for the Design of Complex Trait Association Studies

(2009) Bingshan Li et al.   PLoS Genetics

A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic

(2009) Bo Eskerod Madsen et al.   PLoS Genetics

Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data

(2008) Bingshan Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia

(2008) Wenjia Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

E protein dosage influences brain development more than family member identity

(2008) Ali C. Ravanpay et al.   JOURNAL OF NEUROSCIENCE RESEARCH