TCF4(e2-2; ITF2): A schizophrenia-associated gene with pleiotropic effects on human disease

Gliomas display a microRNA expression profile reminiscent of neural precursor cells

(2017) Iris Lavon et al.   NEURO-ONCOLOGY

Association of TCF4 and CLU polymorphisms with Fuchs’ endothelial dystrophy and implication of CLU and TGFBI proteins in the disease process

(2012) Abraham Kuot et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Association of the Type 2 Diabetes Mellitus Susceptibility Gene, TCF7L2, with Schizophrenia in an Arab-Israeli Family Sample

(2012) Anna Alkelai et al.   PLoS One

Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating

(2012) B. B. Quednow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmacytoid dendritic cells control T-cell response to chronic viral infection

(2012) L. Cervantes-Barragan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription Factor TCF4 Maintains the Properties of Human Corneal Epithelial Stem Cells

(2012) Rong Lu et al.   STEM CELLS

Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain

(2011) Hywel J. Williams et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia

(2011) Thomas Hansen et al.   BIOLOGICAL PSYCHIATRY

Transcription Factor-Induced Lineage Selection of Stem-Cell-Derived Neural Progenitor Cells

(2011) Lia Panman et al.   Cell Stem Cell

CREB in adult neurogenesis - master and partner in the development of adult-born neurons?

(2011) Katharina Merz et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Olig1 is expressed in human oligodendrocytes during maturation and regeneration

(2011) Ahmad Othman et al.   GLIA

Neurologic and ocular phenotype in Pitt–Hopkins syndrome and a zebrafish model

(2011) Antje Brockschmidt et al.   HUMAN GENETICS

Common variants at VRK2 and TCF4 conferring risk of schizophrenia

(2011) Stacy Steinberg et al.   HUMAN MOLECULAR GENETICS

Novel comprehensive diagnostic strategy in Pitt-Hopkins syndrome: Clinical score and further delineation of the TCF4 mutational spectrum

(2011) Sandra Whalen et al.   HUMAN MUTATION

miRWalk – Database: Prediction of possible miRNA binding sites by “walking” the genes of three genomes

(2011) Harsh Dweep et al.   JOURNAL OF BIOMEDICAL INFORMATICS

The Schizophrenia Risk Allele C of the TCF4 rs9960767 Polymorphism Disrupts Sensorimotor Gating in Schizophrenia Spectrum and Healthy Volunteers

(2011) B. B. Quednow et al.   JOURNAL OF NEUROSCIENCE

The Master Negative Regulator REST/NRSF Controls Adult Neurogenesis by Restraining the Neurogenic Program in Quiescent Stem Cells

(2011) Z. Gao et al.   JOURNAL OF NEUROSCIENCE

Transcription and pathway analysis of the superior temporal cortex and anterior prefrontal cortex in schizophrenia

(2011) Michael R. Barnes et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets

(2011) E Kwon et al.   MOLECULAR PSYCHIATRY

Spatio-temporal transcriptome of the human brain

(2011) Hyo Jung Kang et al.   NATURE

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

(2011)   NATURE GENETICS

Replication of TCF4 through Association and Linkage Studies in Late-Onset Fuchs Endothelial Corneal Dystrophy

(2011) Yi-Ju Li et al.   PLoS One

Functional Diversity of Human Basic Helix-Loop-Helix Transcription Factor TCF4 Isoforms Generated by Alternative 5′ Exon Usage and Splicing

(2011) Mari Sepp et al.   PLoS One

Non-Coding RNAs in Neural Networks, REST-Assured

(2011) Michael Rossbach   Frontiers in Genetics

Cognitive and Sensorimotor Gating Impairments in Transgenic Mice Overexpressing the Schizophrenia Susceptibility Gene Tcf4 in the Brain

(2010) Magdalena M. Brzózka et al.   BIOLOGICAL PSYCHIATRY

Epigenetic Studies of Psychosis: Current Findings, Methodological Approaches, and Implications for Postmortem Research

(2010) Ruth Pidsley et al.   BIOLOGICAL PSYCHIATRY

Disturbed synaptic connectivity in schizophrenia: Convergence of genetic risk factors during neurodevelopment

(2010) Akiko Hayashi-Takagi et al.   BRAIN RESEARCH BULLETIN

ITF2 is a target of CXCR4 in MDA-MB-231 breast cancer cells and is associated with reduced survival in estrogen receptor-negative breast cancer

(2010) Hitesh Appaiah et al.   CANCER BIOLOGY & THERAPY

CXCR4 signaling identifies a role for IFT2 in ER-negative breast cancers

(2010) Jonathan R. Brody et al.   CANCER BIOLOGY & THERAPY

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

(2010) Timothy Ravasi et al.   CELL

Targeting CREB signalling in neurogenesis

(2010) Sebastian Dworkin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries

(2010) H. J. Williams et al.   HUMAN MOLECULAR GENETICS

Continuous Expression of the Transcription Factor E2-2 Maintains the Cell Fate of Mature Plasmacytoid Dendritic Cells

(2010) Hiyaa S. Ghosh et al.   IMMUNITY

E proteins and the regulation of early lymphocyte development

(2010) Renée F. De Pooter et al.   IMMUNOLOGICAL REVIEWS

Mechanisms regulating dendritic cell specification and development

(2010) Stephanie S. Watowich et al.   IMMUNOLOGICAL REVIEWS

Mental retardation, macrostomia and hyperpnoea syndrome

(2010) H. A. SINGH   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility

(2010) C O'Dushlaine et al.   MOLECULAR PSYCHIATRY

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

(2010) Christopher T Johansen et al.   NATURE GENETICS

RNA sequencing: advances, challenges and opportunities

(2010) Fatih Ozsolak et al.   NATURE REVIEWS GENETICS

E2-2 Protein and Fuchs's Corneal Dystrophy

(2010) Keith H. Baratz et al.   NEW ENGLAND JOURNAL OF MEDICINE

De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures

(2010) A Ernst et al.   ONCOGENE

The role of hippocampus dysfunction in deficient memory encoding and positive symptoms in schizophrenia

(2010) Kathrin Zierhut et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

TCF4, Schizophrenia, and Pitt-Hopkins Syndrome

(2010) D. J. Blake et al.   SCHIZOPHRENIA BULLETIN

Functional modules, mutational load and human genetic disease

(2010) Norann A. Zaghloul et al.   TRENDS IN GENETICS

CNTNAP2 and NRXN1 Are Mutated in Autosomal-Recessive Pitt-Hopkins-like Mental Retardation and Determine the Level of a Common Synaptic Protein in Drosophila

(2009) Christiane Zweier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Roles of the Akt/GSK-3 and Wnt Signaling Pathways in Schizophrenia and Antipsychotic Drug Action

(2009) Zachary Freyberg et al.   AMERICAN JOURNAL OF PSYCHIATRY

MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme

(2009) Yiming Li et al.   BRAIN RESEARCH

The miR-17/92 Polycistron Is Up-regulated in Sonic Hedgehog-Driven Medulloblastomas and Induced by N-myc in Sonic Hedgehog-Treated Cerebellar Neural Precursors

(2009) P. A. Northcott et al.   CANCER RESEARCH

Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury

(2009) O. F. Laterza et al.   CLINICAL CHEMISTRY

Small RNAs and developmental timing in plants

(2009) R Scott Poethig   CURRENT OPINION IN GENETICS & DEVELOPMENT

MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness

(2009) Cristina Evangelisti et al.   FASEB JOURNAL

Mutational, functional, and expression studies of theTCF4gene in Pitt-Hopkins syndrome

(2009) Lo��c de Pontual et al.   HUMAN MUTATION

The class I bHLH factors E2-2A and E2-2B regulate EMT

(2009) V. R. Sobrado et al.   JOURNAL OF CELL SCIENCE

Brain and Blood microRNA Expression Profiling of Ischemic Stroke, Intracerebral Hemorrhage, and Kainate Seizures

(2009) Da-Zhi Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

miR-21 and 221 upregulation and miR-181b downregulation in human grade II–IV astrocytic tumors

(2009) Alfredo Conti et al.   JOURNAL OF NEURO-ONCOLOGY

A Genome-Wide Screen for Spatially Restricted Expression Patterns Identifies Transcription Factors That Regulate Glial Development

(2009) H. Fu et al.   JOURNAL OF NEUROSCIENCE

Schizophrenia

(2009) Jim van Os et al.   LANCET

microRNAs miR-124, let-7d and miR-181a regulate Cocaine-induced Plasticity

(2009) Vijay Chandrasekar et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Identification of blood biomarkers for psychosis using convergent functional genomics

(2009) S M Kurian et al.   MOLECULAR PSYCHIATRY

Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function

(2009) P R Maycox et al.   MOLECULAR PSYCHIATRY

Neuroscience in the era of functional genomics and systems biology

(2009) Daniel H. Geschwind et al.   NATURE

PeakSeq enables systematic scoring of ChIP-seq experiments relative to controls

(2009) Joel Rozowsky et al.   NATURE BIOTECHNOLOGY

Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis

(2009) Matthew B. Johnson et al.   NEURON

ThemiR-17∼92cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma

(2009) Tamar Uziel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring

(2009) K. E. Stephan et al.   SCHIZOPHRENIA BULLETIN

MicroRNA and vascular smooth muscle cell phenotype: new therapy for atherosclerosis?

(2009) Chunxiang Zhang   Genome Medicine

Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism

(2008) Zohreh Talebizadeh et al.   Autism Research

A conserved domain in the transcription factor ITF-2B attenuates its activity

(2008) A. Herbst et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of the proneural gene regulatory network during mouse telencephalon development

(2008) Julia M Gohlke et al.   BMC BIOLOGY

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

(2008) Joachim Silber et al.   BMC Medicine

MiR-92b and miR-9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors

(2008) Dvora Nass et al.   BRAIN PATHOLOGY

Molecular profiles of schizophrenia in the CNS at different stages of illness

(2008) Sujatha Narayan et al.   BRAIN RESEARCH

Transcription Factor E2-2 Is an Essential and Specific Regulator of Plasmacytoid Dendritic Cell Development

(2008) Babacar Cisse et al.   CELL

Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B

(2008) Maho Nagasawa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MicroRNAs Differentially Expressed in ACTH-Secreting Pituitary Tumors

(2008) Fernando Colbari Amaral et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma

(2008) Jessica Pierson et al.   JOURNAL OF NEURO-ONCOLOGY

E protein dosage influences brain development more than family member identity

(2008) Ali C. Ravanpay et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A role for E2-2 at the DN3 stage of early thymopoiesis

(2008) Ingela Wikström et al.   MOLECULAR IMMUNOLOGY

Functional organization of the transcriptome in human brain

(2008) Michael C Oldham et al.   NATURE NEUROSCIENCE

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

(2008) Sébastien S. Hébert et al.   NEUROBIOLOGY OF DISEASE

Heterogeneous dysregulation of microRNAs across the autism spectrum

(2008) Kawther Abu-Elneel et al.   NEUROGENETICS

A miRNA Signature of Prion Induced Neurodegeneration

(2008) Reuben Saba et al.   PLoS One

Genomic Convergence Analysis of Schizophrenia: mRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum

(2008) Joann Mudge et al.   PLoS One

Neuronal distribution in the neocortex of schizophrenic patients

(2008) Manuel F. Casanova et al.   PSYCHIATRY RESEARCH

High-Resolution Mapping of Expression-QTLs Yields Insight into Human Gene Regulation

(2008) Jean-Baptiste Veyrieras et al.   PLoS Genetics