Journal
MATERIALS LETTERS
Volume 227, Issue -, Pages 136-140Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2018.05.059
Keywords
Drug delivery system; Mesoporous silica; Drug adsorption; Mineralization potential
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In this paper the amino-modified mesoporous silica (SBA-NH2) was investigated as a potential bifunctional drug delivery system for cefazolin with both prolonged drug release and mineralization properties. The primary SBA-15 was synthesized using sol-gel method and surface functionalization was carried out using post-synthesis grafting. The obtained SBA-NH2 was characterized by higher adsorption efficiency of cefazolin with drug release prolonged to 7 days compared to primary SBA-15. The amino-modified SBA-15 exhibited also mineralization potential after immersion in simulated body fluid (SBF) with delayed hydroxycarbonate apatite (HCA) formation compared to SBA-15 which did not interrupt the cefazolin release in controlled manner. A bone-mineral-mimicking layer of HCA was formed on the SBA-NH2 surface after 28 days in SBF. (C) 2018 Elsevier B.V. All rights reserved.
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