Anti-Tumorigenic and Anti-Metastatic Activity of the Sponge-Derived Marine Drugs Aeroplysinin-1 and Isofistularin-3 against Pheochromocytoma In Vitro

3D chitinous scaffolds derived from cultivated marine demosponge Aplysina aerophoba for tissue engineering approaches based on human mesenchymal stromal cells

(2017) Vitalii V. Mutsenko et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cytotoxic activity of aeroplysinin-1 against colon cancer cells by promoting β-catenin degradation

(2016) Seoyoung Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells

(2016) Cristina Florean et al.   Oncotarget

Cilengitide combined with cetuximab and platinum-based chemotherapy as first-line treatment in advanced non-small-cell lung cancer (NSCLC) patients: results of an open-label, randomized, controlled phase II study (CERTO)

(2015) J. Vansteenkiste et al.   ANNALS OF ONCOLOGY

Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells

(2015) Fabian Stuhldreier et al.   CANCER LETTERS

Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug

(2015) Javier García-Vilas et al.   Marine Drugs

Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X

(2014) Nan Qin et al.   INTERNATIONAL JOURNAL OF CANCER

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

(2014) Roger Stupp et al.   LANCET ONCOLOGY

Integrative Analyses Identify Osteopontin, LAMB3 and ITGB1 as Critical Pro-Metastatic Genes for Lung Cancer

(2013) Xiao-Min Wang et al.   PLoS One

The Brominated Compound Aeroplysinin-1 Inhibits Proliferation and the Expression of Key Pro- Inflammatory Molecules in Human Endothelial and Monocyte Cells

(2013) Beatriz Martínez-Poveda et al.   PLoS One

Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma

(2013) Merve Erdem et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Poriferan chitin as a template for hydrothermal zirconia deposition

(2013) Marcin Wysokowski et al.   Frontiers of Materials Science

Randomized phase II study of three doses of the integrin inhibitor cilengitide versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer

(2012) Christian Manegold et al.   INVESTIGATIONAL NEW DRUGS

The Antiangiogenic Compound Aeroplysinin-1 Induces Apoptosis in Endothelial Cells by Activating the Mitochondrial Pathway

(2012) Beatriz Martínez-Poveda et al.   Marine Drugs

E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma

(2011) K Araki et al.   BRITISH JOURNAL OF CANCER

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer

(2011) Katherine M. Bell-McGuinn et al.   GYNECOLOGIC ONCOLOGY

Design, synthesis, and biological evaluation of dibromotyrosine analogues inspired by marine natural products as inhibitors of human prostate cancer proliferation, invasion, and migration

(2010) Asmaa A. Sallam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Three-dimensional chitin-based scaffolds from Verongida sponges (Demospongiae: Porifera). Part I. Isolation and identification of chitin

(2010) H. Ehrlich et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Marine Antitumor Drugs: Status, Shortfalls and Strategies

(2010) Ira Bhatnagar et al.   Marine Drugs

Characterization of an animal model of aggressive metastatic pheochromocytoma linked to a specific gene signature

(2009) Lucia Martiniova et al.   CLINICAL & EXPERIMENTAL METASTASIS

Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds  5 1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study

(2008) A. D. Ricart et al.   CLINICAL CANCER RESEARCH

Selective induction of integrin β1 by hypoxia-inducible factor: implications for wound healing

(2008) Simon Keely et al.   FASEB JOURNAL

Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme

(2008) David A. Reardon et al.   JOURNAL OF CLINICAL ONCOLOGY