Total Synthesis of Bioactive Marine Meroterpenoids: The Cases of Liphagal and Frondosin B

Regioselective 1,2-Diol Rearrangement by Controlling the Loading of BF3·Et2O and Its Application to the Synthesis of Related Nor-Sesquiterene- and Sesquiterene-Type Marine Natural Products

(2017) Jun-Li Wang et al.   ORGANIC LETTERS

Platinum-Catalyzed α,β-Unsaturated Carbene Formation in the Formal Syntheses of Frondosin B and Liphagal

(2016) Khoi Q. Huynh et al.   ORGANIC LETTERS

Re-orienting coupling of organocuprates with propargyl electrophiles from SN2′ to SN2 with stereocontrol

(2016) Barry M. Trost et al.   Chemical Science

Total Synthesis and Structure Revision of (−)-Siphonodictyal B and Its Biomimetic Conversion into (+)-Liphagal

(2015) Adrian W. Markwell-Heys et al.   ORGANIC LETTERS

Biogenetically Inspired Total Synthesis of (+)-Liphagal: A Potent and Selective Phosphoinositide 3-Kinase α (PI3Kα) Inhibitor from the Marine SpongeAka coralliphaga

(2014) Takaaki Kamishima et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Frondosins: An Unusual Synthetic and Stereochemical Journey

(2014) Michael D. VanHeyst et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

New Horizons for Old Drugs and Drug Leads

(2014) Gordon M. Cragg et al.   JOURNAL OF NATURAL PRODUCTS

Cyclopropene Cycloadditions with Annulated Furans: Total Synthesis of (+)- and (−)-Frondosin B and (+)-Frondosin A

(2014) E.Zachary Oblak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+/−)-Frondosin B and (+/−)-5-epi-Liphagal by Using a Concise (4+3) Cycloaddition Approach

(2013) Duchan R. Laplace et al.   CHEMISTRY-A EUROPEAN JOURNAL

Climate change in the oceans: evolutionary versus phenotypically plastic responses of marine animals and plants

(2013) Thorsten B. H. Reusch   Evolutionary Applications

Studies on the Total Synthesis of 8-epi-Liphagal

(2012) Jinbao Peng et al.   ACTA CHIMICA SINICA

A Novel, Facile Approach to Frondosin B and 5-epi-Liphagal via a New [4 + 3]-Cycloaddition

(2012) Jie Zhang et al.   ORGANIC LETTERS

The Catalytic Enantioselective Total Synthesis of (+)-Liphagal

(2011) Joshua J. Day et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

InCl3-mediated intramolecular Friedel-Crafts-type cyclization and its application to construct the [6-7-5-6] tetracyclic scaffold of liphagal

(2011) Hao Jiang et al.   Science China-Chemistry

Enantioselective Total Synthesis of the Selective PI3 Kinase Inhibitor Liphagal

(2010) Enrique Alvarez-Manzaneda et al.   ORGANIC LETTERS

Enantiospecific, Biosynthetically Inspired Formal Total Synthesis of (+)-Liphagal

(2010) Jonathan H. George et al.   ORGANIC LETTERS

The organocatalytic three-step total synthesis of (+)-frondosin B

(2010) Maud Reiter et al.   Chemical Science

Asymmetric Synthesis of Seven-Membered Carbocyclic Rings via a Sequential Oxyanionic 5-Exo-Dig Cyclization/Claisen Rearrangement Process. Total Synthesis of (−)-Frondosin B

(2009) Timo V. Ovaska et al.   ORGANIC LETTERS

A concise synthesis of the bioactive meroterpenoid natural product (±)-liphagal, a potent PI3K inhibitor

(2009) Goverdhan Mehta et al.   TETRAHEDRON LETTERS

A total synthesis of (±)-frondosins A and B

(2008) Goverdhan Mehta et al.   TETRAHEDRON LETTERS