Quantitative analysis of glycation and its impact on antigen binding

Glycation of antibodies: Modification, methods and potential effects on biological functions

(2017) Bingchuan Wei et al.   mAbs

Understanding the Impact of Methionine Oxidation on the Biological Functions of IgG1 Antibodies Using Hydrogen/Deuterium Exchange Mass Spectrometry

(2016) Jingjie Mo et al.   ANALYTICAL CHEMISTRY

EndoS and EndoS2 hydrolyze Fc-glycans on therapeutic antibodies with different glycoform selectivity and can be used for rapid quantification of high-mannose glycans

(2015) Jonathan Sjögren et al.   GLYCOBIOLOGY

Understanding the Conformational Impact of Chemical Modifications on Monoclonal Antibodies with Diverse Sequence Variation Using Hydrogen/Deuterium Exchange Mass Spectrometry and Structural Modeling

(2014) Aming Zhang et al.   ANALYTICAL CHEMISTRY

Investigating the Interaction between the Neonatal Fc Receptor and Monoclonal Antibody Variants by Hydrogen/Deuterium Exchange Mass Spectrometry

(2014) Pernille Foged Jensen et al.   MOLECULAR & CELLULAR PROTEOMICS

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture

(2013) Neil Templeton et al.   BIOTECHNOLOGY AND BIOENGINEERING

Structural Mechanism of Ring-opening Reaction of Glucose by Human Serum Albumin

(2013) Yu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capillary electrophoresis and isoelectric focusing in peptide and protein analysis

(2012) Pier Giorgio Righetti et al.   PROTEOMICS

Controlling glycation of recombinant antibody in fed-batch cell cultures

(2011) Inn H. Yuk et al.   BIOTECHNOLOGY AND BIOENGINEERING

Study of the IgG endoglycosidase EndoS in group A streptococcal phagocyte resistance and virulence

(2011) Jonathan Sjögren et al.   BMC MICROBIOLOGY

Rates and impact of human antibody glycation in vivo

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

Characterization of Site-Specific Glycation During Process Development of a Human Therapeutic Monoclonal Antibody

(2011) Amanda K. Miller et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Glycation of monoclonal antibodies impairs their ability to bind antigen

(2010) D. M. KENNEDY et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies

(2010) Damian Houde et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding

(2010) Damian Houde et al.   MOLECULAR & CELLULAR PROTEOMICS

Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) Damian Houde et al.   ANALYTICAL CHEMISTRY

The effect of sucrose hydrolysis on the stability of protein therapeutics during accelerated formulation studies

(2009) Douglas D. Banks et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Unveiling a Glycation Hot Spot in a Recombinant Humanized Monoclonal Antibody

(2008) Boyan Zhang et al.   ANALYTICAL CHEMISTRY

Maillard Reaction Products in the Escherichia coli-derived Therapeutic Protein Interferon Alfacon-1

(2008) Roumyana Mironova et al.   Annals of the New York Academy of Sciences

A serum substitute for fed-batch culturing of hybridoma cells

(2008) Keisuke Shibuya et al.   CYTOTECHNOLOGY

Glycation during storage and administration of monoclonal antibody formulations

(2008) S FISCHER et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior

(2007) Cynthia Quan et al.   ANALYTICAL BIOCHEMISTRY