Sp1-regulated transcription of RasGRP1 promotes hepatocellular carcinoma (HCC) proliferation

TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication

(2016) Daniel W H Ho et al.   GUT

Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells

(2016) H Ding et al.   LEUKEMIA

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics

(2016) Elisabeth Salzer et al.   NATURE IMMUNOLOGY

miR-612 suppresses stem cell-like property of hepatocellular carcinoma cells by modulating Sp1/Nanog signaling

(2016) Yang Liu et al.   Cell Death & Disease

RasGRP1 opposes proliferative EGFR–SOS1–Ras signals and restricts intestinal epithelial cell growth

(2015) Philippe Depeille et al.   NATURE CELL BIOLOGY

RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines

(2015) O Ksionda et al.   ONCOGENE

Sp1 cooperates with Sp3 to upregulate MALAT1 expression in human hepatocellular carcinoma

(2015) ZILING HUANG et al.   ONCOLOGY REPORTS

Network Modeling of TGF  Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation

(2014) S. N. Steinway et al.   CANCER RESEARCH

Targeted deletion of RasGRP1 impairs skin tumorigenesis

(2014) Amrish Sharma et al.   CARCINOGENESIS

To "Grow" or "Go": TMEM16A Expression as a Switch between Tumor Growth and Metastasis in SCCHN

(2014) D. J. Shiwarski et al.   CLINICAL CANCER RESEARCH

Androgen up-regulates vascular endothelial growth factor expression in prostate cancer cells via an Sp1 binding site

(2013) Kurtis Eisermann et al.   Molecular Cancer

Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis

(2013) C. Hartzell et al.   Science Signaling

Transactivation of the human NME5 gene by Sp1 in pancreatic cancer cells

(2012) Fu Li et al.   GENE

Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo

(2012) H Gil-Henn et al.   ONCOGENE

Cks1 Is Required for Tumor Cell Proliferation but Not Sufficient to Induce Hematopoietic Malignancies

(2012) Susanne Kratzat et al.   PLoS One

c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma

(2011) Hanning You et al.   HEPATOLOGY

Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis

(2011) T Oki et al.   LEUKEMIA

The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1

(2010) M. de la Luz Sierra et al.   BLOOD

mTOR Complex Component Rictor Interacts with PKC  and Regulates Cancer Cell Metastasis

(2010) F. Zhang et al.   CANCER RESEARCH

RasGRP1 Transgenic Mice Develop Cutaneous Squamous Cell Carcinomas in Response to Skin Wounding

(2009) Federico R. Diez et al.   AMERICAN JOURNAL OF PATHOLOGY

Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma

(2009) Muh-Hwa Yang et al.   HEPATOLOGY