New insights into ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance

(2017) Jorge F. Haller et al.   JOURNAL OF LIPID RESEARCH

Use of next-generation sequencing to detectLDLRgene copy number variation in familial hypercholesterolemia

(2017) Michael A. Iacocca et al.   JOURNAL OF LIPID RESEARCH

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

(2017) Nathan O. Stitziel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Angiopoietin-like 3 in lipoprotein metabolism

(2017) Sander Kersten   Nature Reviews Endocrinology

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides

(2017) Mark J. Graham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

(2017) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

LXR-dependent regulation of macrophage-specific reverse cholesterol transport is impaired in a model of genetic diabesity

(2017) Teresa L. Errico et al.   Translational Research

Medical and psychosocial factors and unfavourable low-density lipoprotein cholesterol control in coronary patients

(2017) John Munkhaugen et al.   European Journal of Preventive Cardiology

Cardiovascular safety and efficacy of the PCSK9 inhibitor evolocumab in patients with and without diabetes and the effect of evolocumab on glycaemia and risk of new-onset diabetes: a prespecified analysis of the FOURIER randomised controlled trial

(2017) Marc S Sabatine et al.   Lancet Diabetes & Endocrinology

ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase

(2017) Xun Chi et al.   Molecular Metabolism

Low-Density Lipoprotein Receptor Signaling Mediates the Triglyceride-Lowering Action of Akkermansia muciniphila in Genetic-Induced HyperlipidemiaHighlights

(2016) Jing Shen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Update on the molecular biology of dyslipidemias

(2016) I. Ramasamy   CLINICA CHIMICA ACTA

The majority of lipoprotein lipase in plasma is bound to remnant lipoproteins: A new definition of remnant lipoproteins

(2016) Koichi Sato et al.   CLINICA CHIMICA ACTA

Discontinuation of Statins: What Are the Risks?

(2016) Joel C. Marrs et al.   Current Atherosclerosis Reports

Regulation of lipid metabolism by angiopoietin-like proteins

(2016) Wieneke Dijk et al.   CURRENT OPINION IN LIPIDOLOGY

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors

(2016) Philip L.S.M. Gordts et al.   JOURNAL OF CLINICAL INVESTIGATION

Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey

(2016) Kristian K. Jensen et al.   JOURNAL OF LIPID RESEARCH

Effects of angiopoietin-like protein 3 deficiency on postprandial lipid and lipoprotein metabolism

(2016) Ilenia Minicocci et al.   JOURNAL OF LIPID RESEARCH

Atheroma Progression in Hyporesponders to Statin TherapySignificance

(2015) Yu Kataoka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Liver X receptors at the intersection of lipid metabolism and atherogenesis

(2015) Stephen D. Lee et al.   ATHEROSCLEROSIS

Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin

(2015) P. A. Nidhina Haridas et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

(2015) Yan Wang et al.   JOURNAL OF LIPID RESEARCH

Functional Variants of Lipid Level Modifier MLXIPL, GCKR, GALNT2, CILP2, ANGPTL3 and TRIB1 Genes in Healthy Roma and Hungarian Populations

(2015) Katalin Sumegi et al.   PATHOLOGY & ONCOLOGY RESEARCH

A novel role of angiopoietin-like-3 associated with podocyte injury

(2015) Junchao Liu et al.   PEDIATRIC RESEARCH

Hepatic ANGPTL3 regulates adipose tissue energy homeostasis

(2015) Yan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis

(2015) Paola Dongiovanni et al.   Biomed Research International

Statin and the Risk of Renal-Related Serious Adverse Events: Analysis from the IDEAL, TNT, CARDS, ASPEN, SPARCL, and Other Placebo-Controlled Trials

(2014) Sripal Bangalore et al.   AMERICAN JOURNAL OF CARDIOLOGY

CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism

(2014) Bin Dong et al.   ATHEROSCLEROSIS

Lipoprotein lipase: From gene to atherosclerosis

(2014) Yuan Li et al.   ATHEROSCLEROSIS

The effect of moderate-dose versus double-dose statins on patients with acute coronary syndrome in China: Results of the CHILLAS trial

(2014) Shui-ping Zhao et al.   ATHEROSCLEROSIS

Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation

(2014) Anna Tikka et al.   BIOSCIENCE REPORTS

Short- and long-term effects of Xuezhikang (血脂康), an extract of cholestin, on serum proprotein convertase subtilisin/kexin type 9 levels

(2014) Yan-jun Jia et al.   Chinese Journal of Integrative Medicine

Hypobetalipoproteinemia and abetalipoproteinemia

(2014) Francine K. Welty   CURRENT OPINION IN LIPIDOLOGY

Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents

(2014) Wei-fen Zhu et al.   Lipids in Health and Disease

Angptl3 Deficiency Is Associated With Increased Insulin Sensitivity, Lipoprotein Lipase Activity, and Decreased Serum Free Fatty Acids

(2013) Marius R. Robciuc et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Emerging roles of Lipasin as a critical lipid regulator

(2013) Ren Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Short-Term Impact of Low-Dose Atorvastatin on Serum Proprotein Convertase Subtilisin/Kexin Type 9

(2013) Yuan-Lin Guo et al.   CLINICAL DRUG INVESTIGATION

Adipocyte triglyceride turnover and lipolysis in lean and overweight subjects

(2013) Mikael Rydén et al.   JOURNAL OF LIPID RESEARCH

Dietary Alleviation of Maternal Obesity and Diabetes: Increased Resistance to Diet-Induced Obesity Transcriptional and Epigenetic Signatures

(2013) Linda Attig et al.   PLoS One

Induction of ABCA1 and ABCG1 expression by the liver X receptor modulator cineole in macrophages

(2012) Hee-jin Jun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Atypical angiopoietin-like protein that regulates ANGPTL3

(2012) F. Quagliarini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiopoietin-like Protein 3 Inhibits Lipoprotein Lipase Activity through Enhancing Its Cleavage by Proprotein Convertases

(2010) Jun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of high-dose statin on the human hepatic expression of genes involved in carbohydrate and triglyceride metabolism

(2010) C. Pramfalk et al.   JOURNAL OF INTERNAL MEDICINE

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Exome Sequencing,ANGPTL3Mutations, and Familial Combined Hypolipidemia

(2010) Kiran Musunuru et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rationale and design of China intensive lipid lowering with statins in acute coronary syndrome: The CHILLAS study

(2009) Shui-ping Zhao et al.   AMERICAN HEART JOURNAL

Identification of a New Functional Domain in Angiopoietin-like 3 (ANGPTL3) and Angiopoietin-like 4 (ANGPTL4) Involved in Binding and Inhibition of Lipoprotein Lipase (LPL)

(2009) E-Chiang Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Highly Conserved Motif within the NH2-terminal Coiled-coil Domain of Angiopoietin-like Protein 4 Confers Its Inhibitory Effects on Lipoprotein Lipase by Disrupting the Enzyme Dimerization

(2009) Ming-hon Yau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4

(2009) William K. Sonnenburg et al.   JOURNAL OF LIPID RESEARCH

The Angiopoietin-like Proteins ANGPTL3 and ANGPTL4 Inhibit Lipoprotein Lipase Activity through Distinct Mechanisms

(2008) Lu Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Inflammation, Statin Therapy, and Risk of Stroke After an Acute Coronary Syndrome in the MIRACL Study

(2007) Scott Kinlay et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY