Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys

(2015) Viktoria Gusarova et al.   JOURNAL OF LIPID RESEARCH

Antihyperlipidemic Therapies Targeting PCSK9

(2014) Michael Weinreich et al.   Cardiology in Review

Targeting APOC3 in the Familial Chylomicronemia Syndrome

(2014) Daniel Gaudet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Angptl3 Deficiency Is Associated With Increased Insulin Sensitivity, Lipoprotein Lipase Activity, and Decreased Serum Free Fatty Acids

(2013) Marius R. Robciuc et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The angiopoietin-like protein 3

(2013) Marcello Arca et al.   CURRENT OPINION IN LIPIDOLOGY

Microsomal transfer protein inhibition in humans

(2013) Marina Cuchel et al.   CURRENT OPINION IN LIPIDOLOGY

An International Atherosclerosis Society Position Paper: Global recommendations for the management of dyslipidemia-Full report

(2013) Scott M. Grundy et al.   Journal of Clinical Lipidology

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein B Synthesis Inhibition With Mipomersen in Heterozygous Familial Hypercholesterolemia

(2012) Evan A. Stein et al.   CIRCULATION

Mutations in theANGPTL3Gene and Familial Combined Hypolipidemia: A Clinical and Biochemical Characterization

(2012) Ilenia Minicocci et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol

(2012) Evan A. Stein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atypical angiopoietin-like protein that regulates ANGPTL3

(2012) F. Quagliarini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angptl4 deficiency decreases serum triglyceride levels in low-density lipoprotein receptor knockout mice and streptozotocin-induced diabetic mice

(2011) Hironori Adachi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of Three Kindreds With Familial Combined Hypolipidemia Caused by Loss-of-Function Mutations of ANGPTL3

(2011) Livia Pisciotta et al.   Circulation-Cardiovascular Genetics

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

(2010) Lisa S. Pike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Exome Sequencing,ANGPTL3Mutations, and Familial Combined Hypolipidemia

(2010) Kiran Musunuru et al.   NEW ENGLAND JOURNAL OF MEDICINE

The LDL Receptor

(2009) Joseph L. Goldstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification of a New Functional Domain in Angiopoietin-like 3 (ANGPTL3) and Angiopoietin-like 4 (ANGPTL4) Involved in Binding and Inhibition of Lipoprotein Lipase (LPL)

(2009) E-Chiang Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4

(2009) William K. Sonnenburg et al.   JOURNAL OF LIPID RESEARCH

Abnormal Patterns of Lipoprotein Lipase Release into the Plasma in GPIHBP1-deficient Mice

(2008) Michael M. Weinstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

(2008) Tsuguhito Ota et al.   JOURNAL OF CLINICAL INVESTIGATION

GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins

(2008) Anne P. Beigneux et al.   JOURNAL OF LIPID RESEARCH

The hepatic uptake of VLDL inlrp−ldlr−/−vldlr−/−mice is regulated by LPL activity and involves proteoglycans and SR-BI

(2008) Lihui Hu et al.   JOURNAL OF LIPID RESEARCH