Article
Pharmacology & Pharmacy
Baskaran Stephen Inbaraj, Leng-Huei Hua, Bing-Huei Chen
Summary: Resveratrol-gold nanoparticles and a resveratrol nanoemulsion were prepared from grape skin and showed effective inhibition on pancreatic cancer cells, with the nanoemulsion displaying higher inhibition. Further research is needed to study their inhibitory effects on pancreatic tumors in vivo.
Article
Chemistry, Physical
Yifan Ning, Zhe Liu, Shengsong Yang, Yuma Morimitsu, Chinedum O. Osuji, Christopher B. Murray
Summary: The study focuses on incorporating nanoparticles (NPs) into a thermotropic liquid crystal (LC) matrix using linear and dendritic ligands. The dendritic ligands showed better stability and uniform dispersion of NPs in the LC matrix compared to the linear ligand. This research provides a foundation for applications such as tunable optical displays and responsive materials.
CHEMISTRY OF MATERIALS
(2023)
Article
Physics, Applied
Kai Yang, Shenghui Kang, Xiaoyu Wu, Bohua Liu, Chongling Sun, Yanyan Wang
Summary: A high NIR sensitivity and spectral selectivity photothermal detector was developed by modifying a photothermal layer of reduced graphene oxide-Au nanorods hybrid. The detector converts light energy into heat and measures resistance changes. The hybrid material exhibits remarkable photothermal conversion efficiency and dependence on spectral response, resulting in high sensitivity to illumination in the wavelength range from 700 to 1000 nm.
APPLIED PHYSICS LETTERS
(2023)
Article
Biophysics
McKenzie B. Riley, Evan Strandquist, Christopher S. Weitzel, Jeremy D. Driskell
Summary: Research shows that the thiolated analog of a protein has a greater affinity for gold nanoparticles (AuNPs) and is able to form a robust hard corona, maintaining structure and function, compared to the unmodified protein which denatures with prolonged exposure to AuNPs resulting in loss of enzymatic function.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Peter R. Christenson, Manci Li, Gage Rowden, Peter A. Larsen, Sang-Hyun Oh
Summary: Misfolded proteins associated with neurodegenerative diseases can accumulate in tissues or circulate in biological fluids before the onset of clinical symptoms, making them ideal diagnostic targets. Adding nanoparticles to the RT-QuIC assay improves its speed and sensitivity, which is crucial for diagnostic application.
Article
Chemistry, Multidisciplinary
Karolina Majsterkiewicz, Artur P. Biela, Sourav Maity, Mohit Sharma, Bernard M. A. G. Piette, Agnieszka Kowalczyk, Szymon Gawel, Soumyananda Chakraborti, Wouter H. Roos, Jonathan G. Heddle
Summary: The structure of an artificial protein cage triggered by gold nanoparticles was successfully predicted, and it was discovered that each cage contains gold nanoparticles, which can be used to achieve regular arrangement of the nanoparticles.
Article
Biochemistry & Molecular Biology
Vinod D. Jaiswal, Dhanashri S. Pangam, P. M. Dongre
Summary: The biophysical study quantitatively understands biomolecular interaction, especially the interaction between protein-nanoparticle. This study focuses on the biophysical characterization of cisplatin loaded BSA with gold nanoparticles and its interaction with glycan sugars of the glycoprotein receptor. Spectroscopic studies show strong binding between CPT loaded BSA and GNP, while circular dichroism spectroscopy reveals weak alteration in the secondary structure of BSA. Dynamic light scattering and zeta potential data indicate changes in conjugate size and stability. The investigation explores the mechanisms of interaction at the molecular and cellular levels and has potential applications in targeted drug delivery for cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Matthew Faria, Stuart T. Johnston, Andrew J. Mitchell, Edmund Crampin, Frank Caruso
Summary: Evaluating the potential of nanomaterials for biological applications involves investigating their interactions with cells and biological fluids, with the choice of appropriate metrics being crucial. Some commonly used metrics in bio-nano scientific literature have significant issues and may not deliver the intended insight.
CHEMISTRY OF MATERIALS
(2021)
Review
Immunology
Anirban Sengupta, Mohammad Azharuddin, Noha Al-Otaibi, Jorma Hinkula
Summary: The use of gold nanoparticles (GNPs) in vaccine development has gained popularity due to their excellent properties in biocompatibility, immune modulation, and antigen delivery. GNPs can effectively combat various pathogens by modulating immune responses of cells and antibodies. Despite their potential toxicity, it is worth further exploring and investing in GNPs for vaccine development.
Article
Chemistry, Multidisciplinary
Jahar Dey, Sang-Jo Lee, Jiwhan Kim, Sung-Hwan Lim, Jae-Min Ha, Min-Jae Lee, Sung-Min Choi
Summary: This study introduces a method for forming nanoparticle supercrystals driven by covalent bonding interactions, which provide stronger structural stability compared to traditional intermolecular forces. The versatility and cost-effectiveness of the covalent bonding approach make it highly practical for various applications.
Article
Materials Science, Multidisciplinary
Werner E. G. Mueller, Heinz C. Schroeder, Meik Neufurth, Xiaohong Wang
Summary: This review explores the use of inorganic polyphosphate (polyP) as a potential novel agent against COVID-19, focusing on its ability to block the binding of the virus to cells through electrostatic interaction. Additionally, polyP upregulates the expression of mucin genes in epithelial cells, potentially reinforcing the defense barrier against virus infiltration.
Article
Nanoscience & Nanotechnology
Ying Shi, Kefeng Pu, Haodong Yao, Yingting Chen, Xuewen Zheng, Lina Zhao, Xiaochuan Ma, Cuicui Ge
Summary: Gold nanorods (Au NRs) can induce changes in the secondary structure of MMP-9 and inhibit their activity, with inhibition efficiency depending on the aspect ratio of Au NRs, with an aspect ratio of 3.3 showing the maximum inhibition. Molecular dynamics simulations and mathematical statistics algorithms reveal the binding behaviors and interaction modes between MMP-9 and Au NRs, explaining the aspect ratio-dependent inhibition effect on MMP-9 activity. Au NRs with an aspect ratio of 3.3 successfully suppress X-ray-activated tumor invasion and metastasis by inhibiting MMP-9 activity, providing important guidance for modulating MMP-9 activity and demonstrating the potential of gold nanorods as MMP inhibitors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Kosin Teeparuksapun, Martin Hedstrom, Bo Mattiasson
Summary: A capacitive biosensor for the detection of protein A was developed using layer-by-layer assembly method. The performance of the sensor showed a linear response in a wide concentration range, with low detection limit, making it suitable for the detection of trace amounts of protein A.
Article
Engineering, Environmental
Maofei Ni, Rui Liu, Weijun Luo, Junbing Pu, Jing Zhang, Xiaodan Wang
Summary: Human-induced disturbances accelerate the biogeochemical processes of dissolved carbon, resulting in more riverine CO2 generation and increased transformations of dissolved carbon in karst environments. Farmland and forests are the main sources of riverine organic carbon, while land-use fragmentation increases the diversity of dissolved organic carbon. Reducing anthropogenic disturbances can decelerate organic carbon metabolism and promote riverine CO2 sequestration.
Article
Chemistry, Multidisciplinary
Xiuxiu Wang, Zong-Chang Han, Wei Wei, Hanshi Hu, Pengfei Li, Peiqing Sun, Xiangzhi Liu, Zhijia Lv, Feng Wang, Yi Cao, Zijian Guo, Jun Li, Jing Zhao
Summary: Metal clusters, such as iron-sulfur clusters, play important roles in sustaining life and metalloprotein functions. In this study, the formation and crystal structure of a planar square tetranuclear silver cluster were reported when silver ions were mixed with human copper chaperone Atox1. Quantum chemical studies revealed that the tetranuclear silver cluster has an aromatic all-metal structure, representing the first observation of such structure in a protein.
Article
Materials Science, Biomaterials
Socrates Radhakrishnan, Sakthivel Nagarajan, Habib Belaid, Cynthia Farha, Igor Iatsunskyi, Emerson Coy, Laurence Soussan, Vincent Huon, Jonathan Bares, Kawthar Belkacemi, Catherine Teyssier, Sebastien Balme, Philippe Miele, David Cornu, Narayana Kalkura, Vincent Cavailles, Mikhael Bechelany
Summary: In this study, silver nanoparticles were successfully synthesized in a PCL solution and further extruded into filaments for 3D printing. The fabricated scaffolds exhibited interconnected porous structures and demonstrated 80% degradation in 20 days in enzymatic degradation studies. The scaffolds showed cytocompatibility with bone cells and antibacterial activity against Escherichia coli, making them promising for bone tissue engineering applications.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Tianji Ma, Nicolas Arroyo, Jean Marc Janot, Fabien Picaud, Sebastien Balme
Summary: The modification of the inner nanopore wall by polymers, particularly polyethylene glycol (PEG), is important for changing the specific properties of nanosystems. Research has shown that the presence of PEG inside a nanopore can affect its properties, especially with regards to the cation type in the electrolyte.
Article
Chemistry, Physical
Nicolas Arroyo, Sebastien Balme, Fabien Picaud
Summary: The study investigated the conformation of PEG inside hydrophobic and hydrophilic nanopores through molecular dynamic simulation, showing that the nanopore inner surface affects the organization of PEG and the speed of salt constituents. The pair interaction between PEG and its environment demonstrates a greater affinity for K+ cations compared to Li+ cations.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Chemistry, Analytical
Lucile Reynaud, Aurelie Bouchet-Spinelli, Jean-Marc Janot, Arnaud Buhot, Sebastien Balme, Camille Raillon
Summary: Solid-state nanopores are used for discriminating closely related proteins alpha-thrombin and gamma-thrombin, with aptamer functionalization enhancing discrimination. Postprocessing signals with machine learning and training algorithms, an accuracy of 98.8% is achieved using seven features and ensemble methods.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Graycyelle R. S. Cavalcanti, Francisco Rodrigues, Guanzheng Zhuang, Sebastien Balme, Jean-Marc Janot, Maria G. Fonseca, Maguy Jaber
Summary: Hybrid pigments based on carminic acid stabilized by clay minerals were prepared and characterized using various techniques. The pigments showed different stability levels, with the hydrogels covered in polyorganosilane exhibiting the highest light stability.
Article
Chemistry, Multidisciplinary
Nathan Meyer, Nicolas Arroyo, Jean-Marc Janot, Mathilde Lepoitevin, Anna Stevenson, Imad Abrao Nemeir, Veronique Perrier, Daisy Bougard, Maxime Belondrade, Didier Cot, Jeremy Bentin, Fabien Picaud, Joan Torrent, Sebastien Balme
Summary: This study investigates the impact of nanoscale geometry and molecular crowding on Aβ fibril sensing using nanopore technology. It was found that a conical nanopore functionalized with PEG 5 kDa can discriminate fibril size, while a bullet-like-shaped nanopore enhances current amplitude and dwell time. However, a nanopore crowded with PEG 20 kDa increases relative current blockade without improving fibril discrimination compared to the bullet-shaped nanopore.
Review
Chemistry, Physical
Nathan Meyer, Imad Abrao-Nemeir, Jean-Marc Janot, Joan Torrent, Mathilde Lepoitevin, Sebastien Balme
Summary: In the past two decades, solid state and polymer nanopores have emerged as attractive methods for protein sensing, offering high specificity and sensitivity. This review focuses on the technique of protein detection using resistive pulse and ionic diodes, discussing significant achievements in detecting peptides and proteins, as well as strategies for improving nanopore resolution and accuracy. Challenges such as protein adsorption and nanopore lifetime are also highlighted.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Applied
Romain Vian, Hamideh Salehi, Marion Lapierre, Frederic Cuisinier, Vincent Cavailles, Sebastien Balme
Summary: This study focused on TiO2 nanoparticles (E171) and investigated the impact of protein adsorption on their aggregation and cell penetration. The results indicated that the protein coating could enhance the colloidal stability of TiO2 nanoparticles and promote cell penetration.
Article
Engineering, Chemical
Imad Abrao-Nemeir, Oumaima Zaki, Nathan Meyer, Mathilde Lepoitevin, Joan Torrent, Jean-Marc Janot, Sebastien Balme
Summary: In this study, two strategies based on single nanopore sensing and multipore membrane were combined to separate, detect, and identify antibodies. The ability to detect antibodies specifically in a single nanopore was demonstrated, and a multipore membrane was also designed to extract antibodies effectively.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Physical
Tien-Juin Liu, Tianji Ma, Chih-Yuan Lin, Sebastien Balme, Jyh-Ping Hsu
Summary: The study investigates the switching of ON and OFF states of an ionic diode using PE bilayers deposited layer-by-layer, demonstrating ultrahigh ion rectification at low pH levels. The remarkable gating behavior is explained by the anion-pump-induced ion accumulation in the neutral region and depletion zone at the interface, showing the potential for achieving ultrahigh rectification in a unipolar-like configuration.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Environmental Sciences
Nathan Meyer, Nicolas Arroyo, Matteo Baldelli, Nicolas Coquart, Jean Marc Janot, Veronique Perrier, Mauro Chinappi, Fabien Picaud, Joan Torrent, Sebastien Balme
Summary: This study analyzed the interaction between pyrimethanil and A beta (1-42) using conical track-etched nanopore and found that pyrimethanil promotes the aggregation of A beta (1-42). The study also revealed the mechanism of pyrimethanil-induced aggregation of A beta (1-42) involving two steps including reorganization and elongation phase prior to aggregation.
Article
Chemistry, Multidisciplinary
Nathan Meyer, Jean-Marc Janot, Joan Torrent, Sebastien Balme
Summary: In this study, a proof of concept real-time fast amyloid seeding and translocation (RT-FAST) method based on a nanopipette was presented. It combines a reaction vessel and a nanopore sensor in one system to detect α-synuclein assemblies. The method allows rapid and accurate detection of α-synuclein seeds in a sample within 90 minutes, and it has the potential for quantitative analysis of seed concentration.
ACS CENTRAL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Imad Abrao-Nemeir, Jeremy Bentin, Nathan Meyer, Jean-Marc Janot, Joan Torrent, Fabien Picaud, Sebastien Balme
Summary: Solid-state nanopores are a promising technology for high-throughput, label-free analysis of protein aggregation. In this study, we coated the surface of a silicon nitride nanopore with levodopamine to reduce nonspecific adsorption, and investigated its application in characterizing the aggregation of amyloid-beta and alpha-synuclein.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Pelagie Kamgang-Syapnjeu, Dayirou Njoya, Elie Kamseu, Sebastien Balme, Mikhael Bechelany, Laurence Soussan
Summary: This study investigates the characteristics and performance of bio-based ceramic membranes made from kaolinite clays, coconut husks, and eggshells for the removal of E. coli bacteria in drinking water. The membranes were characterized using TGA, DSC, mercury porosimetry, and SEM. Water flux density, bacterial removal, and biofouling were evaluated. The results show that the best membrane, S3, achieved 100% bacterial removal with a water flux density of 2123 +/- 72 L/h/m(2) at an initial pressure of 0.2 bar. The production protocol for this membrane is simple, fast, and does not require chemical additives.
Editorial Material
Chemistry, Multidisciplinary
Sebastien Balme
ACS CENTRAL SCIENCE
(2023)