Article
Biochemistry & Molecular Biology
Sonja Dragojevic, Lindsay Turner, Drazen Raucher
Summary: In this study, a macromolecular drug delivery system was examined for its ability to specifically deliver doxorubicin to cancer cells. The cytotoxicity and mechanism of action of two doxorubicin derivatives were compared in dox-responsive and dox-resistant cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sonja Dragojevic, Jung Su Ryu, Michael E. Hall, Drazen Raucher
Summary: Doxorubicin is a widely used anticancer drug, but its adverse effects on healthy tissues limit its clinical application. To address this issue, researchers have developed a thermally responsive biopolymer carrier for doxorubicin that can be targeted to tumor tissue by applying heat.
Article
Chemistry, Multidisciplinary
Made Budiarta, Sathi Roy, Tobias Katenkamp, Neus Feliu, Tobias Beck
Summary: Due to its pharmacological properties, ferritin (Ftn) is used as a drug delivery vehicle to reduce the cardiotoxicity of doxorubicin (DOX) in chemotherapy. However, DOX encapsulation in Ftn faces challenges such as precipitation and low protein recovery yield. A new strategy using cysteine-maleimide conjugation for DOX encapsulation in Ftn is proposed and shown to be more efficient. The surface charges of Ftn variants affect the cytotoxicity, DOX loading, and cellular uptake mechanism.
Review
Chemistry, Multidisciplinary
Meihua Yu, Wei Yang, Wenwen Yue, Yu Chen
Summary: With the advancements in nanoengineering, therapeutic immunostimulators formulated in nanomaterials have shown great potential in cancer treatment. Nanoformulations offer precise regulation of immune activities and can target specific immune cells. This review discusses recent developments in nanoformulations targeting immune cells and highlights the opportunities and challenges in clinical translation for targeted cancer immunotherapy.
Article
Pharmacology & Pharmacy
Sonja Dragojevic, Lindsay Turner, Pallabi Pal, Amol Janorkar, Drazen Raucher
Summary: Glioblastoma (GBM) is a primary brain tumor with poor prognosis. Tumor recurrence and resistance to chemotherapy are the main challenges. This study evaluated the potential of using elastin-like polypeptide (ELP) hydrogels as a local drug delivery system for GBM treatment. Results showed that ELP hydrogels can be engineered to release anti-cancer drugs over time, significantly reducing GBM cell survival and proliferation in vitro. These findings highlight the potential of ELP hydrogels for improving prognosis in GBM patients after tumor resection.
Article
Polymer Science
Bingbing Zhao, Yuting Yan, Junmei Zhang, Enping Chen, Ke Wang, Changshun Zhao, Yinan Zhong, Dechun Huang, Zhiqin Cui, Dawei Deng, Congying Gu, Wei Chen
Summary: A novel zwitterionic triblock copolymer was designed and synthesized, showing well-defined structure and controlled molecular weight; the copolymer could self-assemble into polymersomes with good biocompatibility and cell transmembrane ability; cytochrome c-loaded polymersomes exhibited potent cancer inhibitory activity and apoptosis-inducing ability against HeLa cells.
Article
Pharmacology & Pharmacy
Zihua Zeng, Jianjun Qi, Quanyuan Wan, Youli Zu
Summary: Doxorubicin (DOX) is a common anti-tumor drug that has been utilized to form aptamer-drug conjugates for targeted cancer therapy. The synthesized Apt-TNM-DOX conjugate has high drug payloads and pH-dependent drug release, allowing for specific targeting of lymphoma cells in a simple and non-toxic manner. This targeted therapeutic approach may reduce non-specific side effects associated with traditional chemotherapy.
Article
Engineering, Biomedical
Sudipta Mallick, Ramadan Abouomar, David Rivas, Max Sokolich, Fatma Ceren Kirmizitas, Aditya Dutta, Sambeeta Das
Summary: Micro-sized magnetic particles, known as microrobots, have shown potential for biomedical applications such as drug delivery and cell manipulation. This study used microrobots to deliver anticancer drugs to cancer cells, resulting in cell death. The findings confirm the promise of microrobots as precise couriers for targeted delivery of therapeutic biomolecules for cancer therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Polymer Science
Erhan Demirel, Yasemin Yuksel Durmaz
Summary: Combination therapy involving anticancer drugs and gene therapy agents has been proven effective in treating different types of cancer. In this study, a modified strategy was developed to enhance the use of reduced graphene oxide (rGO) as a carrier for delivering drugs and nucleotides. The newly designed copolymer allowed for the conjugation of a targeting peptide and the loading of hydrophobic drugs, resulting in a multifunctional nanoplatform with controlled drug release and high transfection efficiency. The experiments demonstrated the potential of this nanoplatform in selectively delivering different cargoes to tumor sites.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biophysics
Shuang Fu, Yinan Zhao, Jiao Sun, Ting Yang, Defu Zhi, Enxia Zhang, Fangli Zhong, Yuhong Zhen, Shufen Zhang, Shubiao Zhang
Summary: RGD-modified liposomes showed excellent active targeting ability for integrin ?v?3 receptors and enhanced DOX release due to their pH-sensitivity, resulting in significant antitumor efficacy with low toxicity. This new approach provides a potential avenue for improved tumor therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Physical
Xiaoyu Wu, Xiangkun Huan, Yimiao Zhu, Gang Yang, Hao Yang, Zhenfeng Wu, WenWen Xu
Summary: Molecular dynamics simulations were used to investigate covalently functionalized carbon nanotubes (f-CNTs) loaded with doxorubicin (DOX) and LL 37. f-CNTs were functionalized with carboxyl, hydroxyl, and amine groups. The adsorption of DOX molecules and LL-37 was studied in different molar proportions. The binding energy, radial distribution function, and conformational changes of the peptide were analyzed. The study revealed that hydroxyl-functionalized CNTs are suitable carriers in a 1:1 ratio of DOX to LL-37, while amine-functionalized CNTs are suitable carriers in a 2:1 ratio. These findings have implications for dual drug delivery systems.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Pharmacology & Pharmacy
Vivek Makwana, Jasmine Karanjia, Thomas Haselhorst, Shailendra Anoopkumar-Dukie, Santosh Rudrawar
Summary: Liposomal delivery systems have greatly improved the efficacy and safety of chemotherapeutic agents, particularly in the case of doxorubicin. Surface modification of liposomes, such as pegylation, can prolong drug circulation time and enhance drug accumulation in tumor tissue through passive targeting. Active targeting using biological ligands on the liposome surface shows potential for further improving tumor targeting efficiency in drug delivery systems.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Wei-Hsiang Hsu, Chien-Liang Ku, You-Ren Lai, Steven S. -S. Wang, Shiu-Huey Chou, Ta-Hsien Lin
Summary: This study aimed to develop DOXO-coupled glycated BSA nanoparticles and improve their targeting capability towards GLUT5 transporters over-expressed on breast cancer cells. The synthesized nanoparticles had a spherical shape with a hydrodynamic diameter of approximately 60.74 nm and a zeta-potential of approximately -42.20 mV. Furthermore, the DOXO-coupled glycated BSA nanoparticles exhibited cytotoxicity towards both MCF-7 and MDA-MB-231 cells. Overall, this research demonstrates the potential of drug-coupled glycated BSA nanoparticles as a targeted drug delivery platform for breast cancer therapy. Rating: 9/10.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Ezaldeen Esawi, Walhan Alshaer, Ismail Sami Mahmoud, Dana A. Alqudah, Bilal Azab, Abdalla Awidi
Summary: The study developed a chimera consisting of two aptamers to selectively deliver doxorubicin into cancer cells and release the drug inside cells. Results demonstrate the selective uptake of the chimera into cancer cells, successful delivery of doxorubicin to targeted cells, inhibition of cancer cell growth, and reduced cytotoxicity on normal cells, indicating the potential of the AS1411-ATP aptamer chimera as an innovative drug delivery system for improved therapeutic efficacy with decreased off-target cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Fangfang Jin, Qian Zeng, Husun Qian, Dian Zhang, Yu Wei, Yange Wang, Chengsen Chai, Wei Cheng, Shijia Ding, Tingmei Chen
Summary: A dual-targeted aptamer-decorated DNA hydrogel system (DTA-H) is reported for efficient, stable, and targeted delivery of drugs, showing significant potential for cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Zhi-Xuan Huang, Wei-Feng Lin, Yin Zhang, Chuan-He Tang
Summary: The development of cholesterol-free mayonnaise is of great interest in the food colloid field. This study presents an effective strategy to fabricate high freeze-thaw stability emulsions using heated soy protein isolate (SPI) and chitosan (CS) complexes as emulsifiers and stabilizers. The complexes showed a high capacity to stabilize emulsions and improve freeze-thaw stability. The results indicate that the SPI/CS complexes could be a potential replacement for cholesterol-rich mayonnaise.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Junguo Li, Weifeng Lin, Yingjie Shao, Tianren Tang, Wei Qiang, Zhaohui Pan, Yuanhai Su, Minjing Shang
Summary: In this study, the synthesis of 2,3,5-trimethylbenzoquinone (TMBQ) using microreactors was investigated. By optimizing the reaction temperature, residence time, molar ratio of TBHP to TMP, and injection strategy, a maximum yield of 73% was achieved. The results demonstrated the effectiveness of the continuous-flow protocol in the process intensification for TMBQ synthesis.
JOURNAL OF FLOW CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Yihui Dong, Weifeng Lin, Aatto Laaksonen, Xiaoyan Ji
Summary: This review summarizes the use of four powerful techniques, HPLC, AFM, SERS, and MD simulations, to study the interaction between protein and porous TiO2 materials at different scales. The results are expected to help optimize the commonly used techniques for characterizing the interfacial behavior of protein on porous TiO2 materials in different applications.
Article
Polymer Science
Jie Zhang, Jing Wang, Guixiu Fan, Bingjie Zhang, Guanglong Ma, Haiyan Xiao, Longgang Wang
Summary: In this study, daptomycin-biomineralized silver nanoparticles (Dap-AgNPs) with good stability and high photothermal conversion efficiency were successfully prepared. Furthermore, they exhibited good biocompatibility and significant anti-tumor ability under irradiation.
Article
Chemistry, Multidisciplinary
Zhefan Yuan, Bowen Li, Wenchao Gu, Sijin Luozhong, Ruoxin Li, Shaoyi Jiang
Summary: This study presents a new approach to enhance immune tolerance and reduce immunological response to AAV vectors by using an immunosuppressive zwitterionic polypeptide. The modified AAV vectors maintain their transduction efficiency while avoiding the production of AAV-specific antibodies.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Sijin Luozhong, Zhefan Yuan, Tara Sarmiento, Yu Chen, Wenchao Gu, Caleb McCurdy, Wenting Gao, Ruoxin Li, Stephan Wilkens, Shaoyi Jiang
Summary: An efficient SLOs-targeting carrier was developed in this study by incorporating phosphatidylserine (PS) into the LNP formulation, resulting in enhanced cellular uptake and SLOs-targeted mRNA delivery through monocyte/macrophage-mediated mechanism.
Article
Nanoscience & Nanotechnology
Ruyu Li, Liyuan Fan, Shengfu Chen, Longgang Wang, Yanshuai Cui, Guanglong Ma, Xiaoyu Zhang, Zhiwei Liu
Summary: In this study, the surface of platinum nanoparticles was modified using zwitterionic molecules, leading to enhanced catalytic activity and antitumor ability. Furthermore, a colorimetric method for dopamine detection based on the peroxidase activity of the modified nanoparticles was developed, with a wide detection range and high specificity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Zhefan Yuan, Patrick McMullen, Sijin Luozhong, Pranab Sarker, Chenjue Tang, Tao Wei, Shaoyi Jiang
Summary: By using hydrophobic interaction chromatography (HIC) technique, we discovered the hidden hydrophobicity in polymers that are typically considered hydrophilic and found a correlation between hidden hydrophobicity and polymer immunogenicity. Through polyzwitterion modification and HIC technique, we are able to generate protein conjugates with extremely low immunogenicity, overcoming the barriers of eliminating anti-drug and anti-polymer antibodies.
Article
Chemistry, Multidisciplinary
Lu Zhang, Quanling Guo, Ruixue Zheng, Qingyu Yu, Ying Liang, Guanglong Ma, Qiurong Li, Xiaoyu Zhang, Haiyan Xiao, Longgang Wang
Summary: Chemotherapy is the main method of treating malignant tumors, but commonly used drugs have high toxicity, poor solubility, low targeting ability, and high side effects. In this study, zwitterionic micelles assembled by modified amphiphilic dendrimers showed great stability and controlled drug release. Moreover, these micelles had higher cellular uptake rates and cytotoxicity, resulting in better tumor inhibition compared to free drugs. Therefore, the prepared targeting nanodrug has great potential for antitumor therapy.
Article
Chemistry, Multidisciplinary
Weili Xue, Xiaowei Lin, Liangbo Xu, Ashish Trital, Yi He, Guping Tang, Hongzhen Bai, Shengfu Chen
Summary: The quick diffusion and precise active targeting are two major challenges in nanomedicine. This study developed a camouflaged nanomedicine to demonstrate the mechanism of zwitterionic shell in barrier-penetration and active targeting. The nanomedicine showed a faster diffusion rate and more precise tumor targeting than similar-sized nanomedicines.
ADVANCED MATERIALS
(2023)
Article
Polymer Science
Shoubei Gao, Kai Liu, Xianbing Ji, Yanshuai Cui, Ruyu Li, Guanglong Ma, Yongqiang Zhang, Longgang Wang
Summary: This paper presents a novel colorimetric method for the detection of hydroquinone based on a peroxidase-like Pd nanozyme. The vancomycin-stabilized palladium nanoparticles (Van-Pd-n NPs) were prepared using vancomycin as a biological template. Van-Pd-2 NPs showed excellent biocompatibility and peroxidase-like activity, making them a promising candidate for the colorimetric detection of hydroquinone.
Article
Chemistry, Multidisciplinary
Xiaolei Guo, Yuzhen Xue, Ruixue Zheng, Shengfu Chen, Weili Xue, Xifa Lan, Longgang Wang, Haiyan Xiao
Summary: The synthesis of biocompatible and efficient polymeric micelles for drug delivery has attracted much attention. In this study, amphiphilic molecules (PMPC) were synthesized using zwitterionic linear polyethyleneimine (PEI) as the hydrophilic segment and mercapto-paclitaxel as the hydrophobic segment. Chemotherapeutic doxorubicin (DOX) was encapsulated in the PMPC micelles to prepare DOX-loaded micelles (PMPC-DOX micelles) through self-assembly. The results showed that the PMPC-DOX micelles exhibited good stability in protein solution and released DOX at a rate of 48.12% within 36 h at pH 5.5. Furthermore, the PMPC-DOX micelles demonstrated superior tumor targeting ability and antitumor effect compared to free DOX, with a tumor inhibition rate of 89.7% after 14 days of treatment. The PEI-based drug-loaded micelles provide a new approach for nanodrug delivery system design.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Medicine, General & Internal
Guang-Long Ma, Wei-Feng Lin
Summary: Immune checkpoint blockade (ICB) therapy has achieved great success in cancer treatment, but only a small fraction of patients respond to it and it can cause immune-related adverse events (irAEs). The use of nanotechnology, particularly liposomal nanomedicine, can enhance the delivery of ICBs to tumors, improve their penetration into tumor tissues, and reduce irAEs. The combination of ICB with liposomal nanomedicine has the potential to improve the efficacy of ICB therapy.
MILITARY MEDICAL RESEARCH
(2023)
Article
Biochemical Research Methods
Di Huang, Yekai Zhao, Mengjun Fang, Peijie Shen, Hu Xu, Yichen He, Shengfu Chen, Zhenjun Si, Zhinan Xu
Summary: In this study, an integrated nucleic acid detection platform called "up and down chip" was developed for HIV-1 detection. It achieved highly sensitive and specific detection of the virus, without the need for professional instruments. The platform shows promising potential for clinical application.
Article
Biochemical Research Methods
Di Huang, Yekai Zhao, Mengjun Fang, Peijie Shen, Hu Xu, Yichen He, Shengfu Chen, Zhenjun Si, Zhinan Xu
Summary: In this study, an integrated nucleic acid detection platform named up and down chip was developed. It simplified the experimental procedures and detection processes, and reduced aerosol pollution risks. The platform combined RT-RAA technology for nucleic acid amplification, DNase-dead Cas12a-modified magnetic beads for specific recognition, and HRP-TMB chromogenic reaction for signal output. It achieved highly sensitive detection of the HIV-1 genome.
