Journal
LANGMUIR
Volume 34, Issue 22, Pages 6556-6569Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.8b01119
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Funding
- Natural Science and Engineering Research Council of Canada (NSERC) Discovery Grant program
- DFG IRTG [2022]
- NSERC CREATE programs for Alberta/TU Munchen International Graduate School
- University of Alberta Department of Chemistry
- Alberta Innovates Technology Futures (AITF)
- University of the Philippines Manila
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This study reports the preparation of functional bioinorganic hybrid materials exhibiting catalytic activity and photoluminescent properties arising from the combination of enzymes and freestanding silicon-based nanoparticles. The hybrid materials reported herein have potential applications in biological sensing/imaging and theranostics, as they combine long-lived silicon-based nanoparticle photoluminescence with substrate-specific enzymatic activity. Thermal hydrosilylation of undecenoic acid and alkene-terminated poly(ethylene oxide) with hydri-determinated silicon nanocrystals afforded nanoparticles functionalized with a mixed surface made up of carboxylic acid and poly(ethylene oxide) moieties. These silicon-based nanoparticles were subsequently conjugated with prototypical enzymes through the carbodiimide-mediated amide coupling reaction in order to form bioinorgamc hybrids that display solubility and photostability in phosphate buffer, photoluminescence (lambda(max) = 630 nm), and enzymatic activity They were characterized using Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), dynamic light scattering analysis (DLS), photoluminescence spectroscopy, and pertinent enzyme activity assays.
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