Article
Pharmacology & Pharmacy
MengLin Chen, Min Chen, Danyi Lu, Yi Wang, Li Zhang, Zhigang Wang, Baojian Wu
Summary: The study focused on investigating the potential role of the Per2 gene in regulating the expression of hepatic CYP2B10, which is responsible for the metabolism and detoxification of many clinical drugs. The study showed that Per2 positively regulates the expression and activity of CYP2B10 in mouse liver by inhibiting its repressor REV-ERB alpha.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Toxicology
Luise Hochmuth, Christiane Korner, Fritzi Ott, Daniela Volke, Kaja Blagotinsek Cokan, Peter Juvan, Mario Brosch, Ute Hofmann, Ralf Hoffmann, Damjana Rozman, Thomas Berg, Madlen Matz-Soja
Summary: The liver is one of the most sexually dimorphic organs, with significant differences in metabolic pathways and disease prevalence between males and females. Research shows that sex affects gene expression, proteome, and metabolome parameters of liver cells, which may have important implications for drug metabolism, treatment, and efficacy.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Qihai Sui, Zhencong Chen, Zhengyang Hu, Yiwei Huang, Jiaqi Liang, Guoshu Bi, Yunyi Bian, Mengnan Zhao, Cheng Zhan, Zongwu Lin, Qun Wang, Lijie Tan
Summary: This study aimed to investigate the causes of resistance to cisplatin, especially in lung adenocarcinoma, and provide guidance for treatment decisions in clinical practice. By analyzing data from Cancer Cell Line Encyclopedia, The Cancer Genome Atlas, and Zhongshan hospital affiliated to Fudan University, the study found that cisplatin resistance was associated with somatic mutations, mRNA expressions, miRNA expressions, metabolites, and methylation. The models created in this study can be used to predict the response and prognosis of patients receiving platinum-based chemotherapies.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Juan Tamargo, Ricardo Caballero, Eva Delpon
Summary: There are significant differences between men and women with heart failure (HF), including the distribution of HF types and response to treatment. However, current clinical guidelines do not provide specific recommendations for women with HF, particularly in terms of drug efficacy and safety.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Medicine, General & Internal
Andre Farkouh, Christoph Baumgaertel, Roman Gottardi, Margit Hemetsberger, Martin Czejka, Alexandra Kautzky-Willer
Summary: There is increasing evidence of sex differences in the action of anti-inflammatory drugs, with women being at significantly higher risk of adverse effects. Men tend to have stronger anti-thrombotic activity with COX-inhibitors, while women are more sensitive to corticosteroids when their estradiol levels are high. Research on sex differences in drug effectiveness and safety is growing, but findings are often anecdotal and controversial, with a lack of systematic sex-differentiated reporting in clinical trials.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Eric Simon, Maciej Motyka, Grietje H. Prins, Mei Li, Werner Rust, Stefan Kauschke, Coralie Viollet, Peter Olinga, Anouk Oldenburger
Summary: There is a need for predictive ex vivo models for NAFLD. This study profiles a new human and mouse PCLSs based assay for steatosis in NAFLD using RNASeq. Steatosis is induced by incremental supplementation of sugars, insulin, and fatty acids, and the gene expression regulation is analyzed across different nutrient conditions and time for both human and mouse liver organ derived PCLSs.
Article
Fisheries
Shuangyan Zhang, Xiaoshang Ru, Libin Zhang, David Goncalves, Hongsheng Yang
Summary: This study investigated the differences in gonadal and intestinal lipid metabolism between male and female sea cucumbers. Transcriptome analysis and metabolome analysis revealed differences in gene expression and metabolite content between males and females. Additionally, the composition and structure of intestinal microbiota were similar between the sexes. These findings are important for improving the reproductive efficiency of sea cucumbers.
Article
Biology
Angela Zhang, Megumi Matsushita, Liang Zhang, Hao Wang, Xiaojian Shi, Haiwei Gu, Zhengui Xia, Julia Yue Cui
Summary: Researchers found that ApoE4-KI mice exposed to cadmium exhibited significant Alzheimer's Disease-related changes in gut microbiota. This highlights the impact of cadmium on ApoE4 gene variants and modification of the gut-liver axis, ultimately affecting cognitive and energy homeostasis.
COMMUNICATIONS BIOLOGY
(2021)
Review
Health Care Sciences & Services
Mirabela Romanescu, Valentina Buda, Adelina Lombrea, Minodora Andor, Ionut Ledeti, Maria Suciu, Corina Danciu, Cristina Adriana Dehelean, Liana Dehelean
Summary: Studies show that there are differences in drug response between men and women, particularly in central nervous system drugs. Different genders significantly influence the pharmacokinetics and pharmacodynamics of drugs. Although many studies have conflicting results, there are certain sex-related differences in each drug class. There are differences in response to opioids, antidepressants, and antipsychotics between genders.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yuting Shan, Lee Cheung, Yuqi Zhou, Yingbo Huang, R. Stephanie Huang
Summary: This review summarizes the current knowledge on sex differences in adverse drug reactions (ADRs) of commonly used psychotropic, cardiovascular, and analgesic medications. The main findings suggest that more than half of the evaluated ADRs show a sex difference in occurrence rate, with some medications causing more adverse reactions in women and others in men.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Neurosciences
Elisa Granocchio, Marinella De Salvatore, Elisa Bonanomi, Daniela Sarti
Summary: This article reviews the research on sex-related differences in the human brain over the past 40 years, particularly in regards to differences in reading ability. It has been found that females perform better in reading tasks and are less susceptible to dyslexia compared to males. These differences are usually explained by environmental factors and genetic differences.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Kiamu Kurosawa, Masataka Nakano, Itsuki Yokoseki, Mai Nagaoka, Seiya Takemoto, Yoshiyuki Sakai, Kaoru Kobayashi, Yasuhiro Kazuki, Tatsuki Fukami, Miki Nakajima
Summary: Inhibitors of bromodomain containing protein 9 (BRD9) can reduce the risk of PXR-mediated adverse reactions by attenuating the transcriptional activity of CYP3A4.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Laura Idda, Ilaria Campesi, Giovanni Fiorito, Andrea Vecchietti, Silvana Anna Maria Urru, Maria Giuliana Solinas, Flavia Franconi, Matteo Floris
Summary: Individual response to drugs is highly variable and largely influenced by genetic variants and gender. Study found significant sex differences in gene expression related to drug response in various human tissues, highlighting the need to address gender bias in clinical trials.
Article
Immunology
Isabelle Coales, Stergios Tsartsalis, Nurun Fancy, Maria Weinert, Daniel Clode, David Owen, Paul M. Matthews
Summary: Sex differences in the transcriptome of human myeloid cells may contribute to the sex difference observed in AD prevalence. AD risk genes, gene signatures associated with AD inflammatory response, and genes related to proinflammatory immune response are enriched in microglial cells and peripheral monocytes from female donors. These findings suggest that a myeloid cell phenotype biased towards expression of biological processes relevant to AD may partly explain the increased prevalence of AD in women.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Cardiac & Cardiovascular Systems
Alessia Argiro, Carolyn Ho, Sharlene M. Day, Jolanda van der Velden, Elisabetta Cerbai, Sara Saberi, Jil C. Tardiff, Neal K. Lakdawala, Iacopo Olivotto
Summary: Cardiomyopathies are diseases characterized by primary functional and structural abnormalities of the heart muscle. The most effective classification is based on the presenting phenotype. Sex modulates the prevalence, clinical manifestations, and course of cardiomyopathies. Differences in ion channel expression and left ventricular remodeling exist between male and female patients. Societal and environmental factors may also contribute to clinical differences between sexes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)