4.4 Article

Differential anxiety-like responses in NOD/ShiLtJ and C57BL/6J mice following experimental autoimmune encephalomyelitis induction and oral gavage

Journal

LABORATORY ANIMALS
Volume 52, Issue 5, Pages 470-478

Publisher

SAGE PUBLICATIONS INC
DOI: 10.1177/0023677218756156

Keywords

anxiety; elevated plus maze; experimental autoimmune encephalomyelitis; gavage; refinement

Funding

  1. Novartis Pharmaceuticals Australia
  2. School of Psychology and Public Health, La Trobe University, Bundoora, Victoria, Australia
  3. Australian Government Department of Education and Training
  4. La Trobe University Postgraduate Research Scholarship (LTUPRS)

Ask authors/readers for more resources

Oral gavage is commonly used in pre-clinical drug evaluation, but is potentially aversive and may induce behavioral effects independent of compounds under investigation. This study examined the combined effects of repeated oral gavage and disease induction on anxiety-like behavior in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. The C57BL/6J and NOD/ShiLtJ EAE variants were exposed to sham-EAE induction or untreated control conditions, and either daily oral gavage or home cage conditions. Anxiety-like behavior was subsequently assessed in the elevated plus maze. C57BL/6J mice exhibited increased anxiety-like behavior, relative to NOD/ShiLtJ mice, in response to repeated gavage, whereas sham-EAE induction and repeated gavage were associated with increased anxiety-like behavior in NOD/ShiLtJ mice. Thus, exposure to the induction procedure and repeated gavage differentially altered subsequent anxiety-like behavior in the two EAE variants. Future pre-clinical studies should rely on prior evaluation of parameters of the experimental design using sham-EAE mice. Additionally, less aversive administration routes should be utilized wherever possible to ensure that procedures do not distort effects of the therapeutic under investigation.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Behavioral Sciences

Social approach, anxiety, and altered tryptophan hydroxylase 2 activity in juvenile BALB/c and C57BL/6J mice

Adrian M. Russo, Adam J. Lawther, Benjamin M. Prior, Luke Isbel, W. Gregory Somers, John A. Lesku, Amanda L. Richdale, Cheryl Dissanayake, Stephen Kent, Christopher A. Lowry, Matthew W. Hale

BEHAVIOURAL BRAIN RESEARCH (2019)

Article Psychology, Biological

Positive verbal feedback about task performance is related with adaptive physiological responses: An experimental study of the effort-reward imbalance stress model

Richard P. Brooks, Monica T. Jones, Matthew W. Hale, Thorsten Lunau, Nico Dragano, Bradley J. Wright

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY (2019)

Article Public, Environmental & Occupational Health

Trait Mindfulness Helps Explain the Relationships Between Job Stress, Physiological Reactivity, and Self-Perceived Health

Pennie Eddy, Eleanor H. Wertheim, Matthew W. Hale, Bradley J. Wright

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2019)

Article Behavioral Sciences

Interactions between whole-body heating and citalopram on body temperature, antidepressant-like behaviour, and neurochemistry in adolescent male rats

Matthew W. Hale, Jodi L. Lukkes, Kathleen F. Dady, Kyle J. Kelly, Evan D. Paul, David G. Smith, Jared D. Heinze, Charles L. Raison, Christopher A. Lowry

BEHAVIOURAL BRAIN RESEARCH (2019)

Article Critical Care Medicine

Mild Closed-Head Injury in Conscious Rats Causes Transient Neurobehavioral and Glial Disturbances: A Novel Experimental Model of Concussion

Louise Pham, Sandy R. Shultz, Hyun Ah Kim, Rhys D. Brady, Ryan C. Wortman, Shannyn G. Genders, Matthew W. Hale, Ross D. O'Shea, Elvan Djouma, Maarten van den Buuse, Jarrod E. Church, Brian R. Christie, Grant R. Drummond, Christopher G. Sobey, Stuart J. McDonald

JOURNAL OF NEUROTRAUMA (2019)

Article Psychology, Biological

An online mindfulness-based program is effective in improving affect, over commitment, optimism and mucosal immunity

Rachael A. Heckenberg, Matthew W. Hale, Stephen Kent, Bradley J. Wright

PHYSIOLOGY & BEHAVIOR (2019)

Article Psychology, Biological

Reduced professional efficacy is associated with a blunted salivary alpha amylase awakening response

Kathleen Landolt, Paul Maruff, Ben Horan, Michael Kingsley, Glynda Kinsella, Paul D. O'Halloran, Matthew W. Hale, Bradley J. Wright

PHYSIOLOGY & BEHAVIOR (2019)

Article Behavioral Sciences

Assessing the association of university stress and physiological reactivity with decision-making among students

Raymond Kuhnell, Zoe Whitwell, Steven Arnold, Michael I. C. Kingsley, Matthew W. Hale, Morten Wahrendorf, Nico Dragano, Bradley J. Wright

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS (2020)

Article Behavioral Sciences

Trait mindfulness and the Effort-Reward Imbalance workplace stress model: Higher trait mindfulness is associated with increased salivary immunoglobulin A

Rachael A. Heckenberg, Matthew W. Hale, Stephen Kent, Bradley J. Wright

BEHAVIOURAL BRAIN RESEARCH (2020)

Article Behavioral Sciences

Empathy and job resources buffer the effect of higher job demands on increased salivary alpha amylase awakening responses in direct-care workers

Rachael A. Heckenberg, Matthew W. Hale, Stephen Kent, Bradley J. Wright

BEHAVIOURAL BRAIN RESEARCH (2020)

Article Multidisciplinary Sciences

Stimulatory, but not anxiogenic, doses of caffeine act centrally to activate interscapular brown adipose tissue thermogenesis in anesthetized male rats

L. Van Schaik, C. Kettle, R. Green, W. Sievers, M. W. Hale, H. R. Irving, D. R. Whelan, J. A. Rathner

Summary: The study found that low doses of caffeine can activate brown adipose tissue thermogenesis through the central nervous system, increasing heat production without adverse cardiovascular effects.

SCIENTIFIC REPORTS (2021)

Article Neurosciences

Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected Behaviours in Adult Mice

Stephanie C. Tran, Emily J. Jaehne, Laura E. Dye, Joanne Wong, Jana S. Bakas, Jemma G. Gasperoni, Matthew W. Hale, Maarten van den Buuse, Sebastian Dworkin, Sylvia V. H. Grommen, Bert De Groef

Summary: Plag1 gene deficiency in mice has mild effects on behavior, with no significant differences in circadian activity levels, locomotion, object recognition, spatial memory, or sociability compared to wild-type mice. However, tests suggest that Plag1 KO mice may have a hearing impairment, indicating a potential role in auditory processes.

NEUROSCIENCE (2021)

Review Immunology

Platelets in Multiple Sclerosis: Early and Central Mediators of Inflammation and Neurodegeneration and Attractive Targets for Molecular Imaging and Site-Directed Therapy

Jacqueline M. Orian, Claretta S. D'Souza, Pece Kocovski, Guy Krippner, Matthew W. Hale, Xiaowei Wang, Karlheinz Peter

Summary: Platelets play important roles not only in thrombosis and hemostasis, but also in inflammatory and immune reactions. They are central to immune responses and may serve as key mediators in autoimmune disorders, such as their association with multiple sclerosis.

FRONTIERS IN IMMUNOLOGY (2021)

Article Behavioral Sciences

Involvement of dorsal raphe nucleus serotonergic systems in social approach-avoidance behaviour and in the response to fluoxetine treatment in peri-adolescent female BALB/c mice

Jennyfer M. Payet, Kira-Elise Wilson, Adrian M. Russo, Anthony Angiolino, William Kavanagh-Ryan, Stephen Kent, Christopher A. Lowry, Matthew W. Hale

Summary: This study examined the involvement of serotonergic systems in social behavior and response to SSRI treatment in peri-adolescent female BALB/c mice. The results showed that chronic fluoxetine treatment led to social approach behavior comparable to controls, while acute fluoxetine treatment increased avoidance behavior. Activation of serotonergic neurons in the dorsal raphe nucleus correlated with social approach behavior. More research is needed to understand the effects and mechanisms of chronic SSRI treatment in females.

BEHAVIOURAL BRAIN RESEARCH (2021)

Article Neurosciences

Long-term effects of young-adult methamphetamine on dorsal raphe serotonin systems in mice: Role of brain-derived neurotrophic factor

Mauricio Sepulveda, Elizabeth E. Manning, Andrea Gogos, Matthew Hale, Maarten van den Buuse

Summary: This study evaluated the long-term effects of chronic METH treatment on the serotonin system in the brain using various techniques. The results indicated that METH treatment can lead to long-term or selective effects on brain serotonin systems. METH pretreatment may affect 5-HT1A receptor binding and reduce DRN cell counts selectively in BDNF HET mice.

BRAIN RESEARCH (2021)

No Data Available