Article
Immunology
Pece Kocovski, Nuzhat Tabassum-Sheikh, Stephanie Marinis, Phuc T. Dang, Matthew W. Hale, Jacqueline M. Orian
Summary: Multiple sclerosis is an autoimmune disease that affects the central nervous system, with unpredictable disease course and a wide range of symptoms. Emotional and cognitive deficits are recognized as primary manifestations, raising questions about the efficacy of current therapeutics for these specific symptoms. Mechanisms underlying psychiatric sequelae in MS are believed to be similar to those underlying pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Joe R. Hilton, Susannah R. Simpson, Emily R. Sherman, Will Raby-Smith, Keemia Azvine, Maite Arribas, Jiaqi Zhou, Serena Deiana, Bastian Hengerer, Emma N. Cahill
Summary: This study investigated whether recalling unpleasant memories in different contextual, olfactory, or auditory conditions would enhance anxiety-like behavior in the elevated plus maze. However, the data did not support the idea that memory recall could influence behavior in the elevated plus maze.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Katharina Robichon, Sven Sondhauss, T. William Jordan, Robert A. Keyzers, Bronwen Connor, Anne C. La Flamme
Summary: This study investigated the tissue distribution and localization of clozapine in the brain using mass spectrometry techniques and found that clozapine was enriched in specific brain regions and significantly elevated in serum during EAE. Additionally, changes in dopamine receptor expression on brain-resident and infiltrating immune cells during EAE were observed, providing insights into how neuroinflammation alters the distribution and downstream effects of clozapine.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Parker Knight, Ranjithkumar Chellian, Ryann Wilson, Azin Behnood-Rod, Stefany Panunzio, Adriaan W. Bruijnzeel
Summary: Female rats exhibit less anxiety-like behavior in the EPM and LOF tests, with sex differences present in almost all behavioral parameters. Additionally, there is a moderate positive correlation between parameters in the EPM and LOF tests.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Immunology
Byunghyun Park, Yu Sun Jeong, Wonseok Hu, Mingyu Lee, Ji Cheol Kim, Geon Ho Bae, Yong-Soo Bae, Yoe-Sik Bae
Summary: Multiple sclerosis (MS) is a disease that damages the brain and spinal cord, leading to paralysis. Recent research has shown that B cells play a significant role in the pathogenesis of MS, as autoantibodies from B cells are closely related to central nervous system damage and prognosis. Regulating the activity of antibody secreting cells may be linked to the severity of MS symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shishi Shen, Xi Cheng, Luyao Zhou, Yipeng Zhao, Hai Wang, Jie Zhang, Xiaobo Sun, Yuge Wang, Yaqing Shu, Yanteng Xu, Yu Tao, Mingqiang Li, Zhengqi Lu, Wei Cai, Guangjun Nie, Wei Qiu
Summary: This study developed neutrophil-derived nanovesicles (NNVs) to enhance the efficiency of myelin debris clearance in microglia for multiple sclerosis (MS) therapy. The results showed that NNVs treatment ameliorated lesional neuroinflammation and improved neurological functions and white matter integrity in a mouse model of MS. Additionally, NNVs treatment upregulated the expression of NRF2 in microglia and activated the transcription of RUBCN, leading to enhanced phagocytosis of myelin debris.
Article
Immunology
Ping Li, Zengli Guo, Yisong Y. Wan
Summary: Research has shown that SKI expression plays a critical role in the differentiation of pathogenic Th17 cells, and controlling SKI expression can modulate the function of these cells and treat Th17-related diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Wenlin Hao, Qinghua Luo, Michael D. Menger, Klaus Fassbender, Yang Liu
Summary: Anti-CD52 therapy demonstrates neuroprotective effects in EAE mice by reducing T lymphocyte counts, preventing myelin loss, and protecting neurons. Neuronal BDNF regulates the neuroprotective and anti-inflammatory effects of CD52 antibody in EAE mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Davide Cossu, Kazumasa Yokoyama, Shigeto Sato, Sachiko Noda, Tamami Sakanishi, Leonardo Antonio Sechi, Nobutaka Hattori
Summary: Research shows that PINK1 protein plays a crucial role in modulating the immune response during EAE, potentially contributing to the pathogenesis of neuroinflammatory and other associated conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Arezoo Hosseini, Tohid Gharibi, Adel Mohammadzadeh, Abbas Ebrahimi-Kalan, Farhad Jadidi-niaragh, Zohreh Babaloo, Dariush Shanehbandi, Elham Baghbani, Behzad Baradaran
Summary: Ruxolitinib ameliorated the severity of EAE by modulating the balance between Th17 cells and Tregs, reducing inflammatory markers levels and increasing levels of anti-inflammatory cytokines.
Article
Behavioral Sciences
Nicolas Cordeiro, Jose Augusto Pochapski, William Sanchez Luna, Gabriel Baltazar, Rainer K. Schwarting, Roberto Andreatini, Claudio Da Cunha
Summary: Ultrasonic vocalizations play a role in conveying emotional states in both young pups and adult rats, with differences observed between genders and developmental stages. Pup vocalizations can predict adult behaviors, while adult vocalizations are influenced by stimulants.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Goran Stegnjaic, Antonios D. Tsiailanis, Milica Lazarevic, Vasileios K. Gkalpinos, Neda Djedovic, Thomas Antoniou, Suzana Stanisavljevic, Mirjana Dimitrijevic, Miljana Momcilovic, Dorde Miljkovic, Andreas G. Tzakos, Bojan Jevtic
Summary: Gallic acid, a phenolic acid found in various plants, nuts, and fruits, has anti-oxidative and anti-inflammatory properties. Its phenethyl ester, PEGA, reduces the release of inflammatory substances and ameliorates an animal model of central nervous system inflammatory disease.
Article
Multidisciplinary Sciences
Hideaki Hasegawa, Izuru Mizoguchi, Naoko Orii, Shinya Inoue, Yasuhiro Katahira, Toshihiko Yoneto, Mingli Xu, Toru Miyazaki, Takayuki Yoshimoto
Summary: IL-23, composed of p19 and p40 subunits, plays a critical role in the expansion of Th17 cells. The composite cytokine p19/CD5L activates STAT5 and enhances differentiation into GM-CSF-producing CD4(+) T cells. Deficiency of p19 or CD5L alleviates EAE with reduced frequency of GM-CSF(+)CD4(+) T cells. Serum level of p19/CD5L correlates with clinical symptoms during EAE, suggesting its role as a novel cytokine contributing to EAE development.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Jie Lv, Mengyao Han, Guangyu Liu, Wei Zhuang, Chun Wang, Ling Xie, Kaidireya Saimaier, Sanxing Han, Changjie Shi, Qiuhong Hua, Ru Zhang, Changsheng Du
Summary: Apoptosis is important in maintaining the homeostasis of the body and immune system, but its dysfunction can lead to autoimmune diseases like multiple sclerosis (MS). An animal model, experimental autoimmune encephalomyelitis (EAE), is used to study MS. In this study, we found that carboplatin (CA), a platinum anti-tumor drug, reduced inflammation and demyelination in EAE mice. CA also decreased pathogenic T cell numbers and proportions in the spleen and lymph nodes of EAE mice. Additionally, CA induced apoptosis and inhibited T cell proliferation. These findings suggest that CA has potential as a novel drug for MS treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rongbo Zhang, Jin Liu, Bin Xu, You Wu, Shunli Liang, Qiang Yuan
Summary: The study investigated the therapeutic effects of cornuside on EAE and its impact on Th17 and Treg cell infiltration. Cornuside showed anti-inflammatory and immunosuppressive effects, alleviating neurological deficits in EAE rats with Th17 cells possibly being one of its therapeutic targets.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Behavioral Sciences
Adrian M. Russo, Adam J. Lawther, Benjamin M. Prior, Luke Isbel, W. Gregory Somers, John A. Lesku, Amanda L. Richdale, Cheryl Dissanayake, Stephen Kent, Christopher A. Lowry, Matthew W. Hale
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Psychology, Biological
Richard P. Brooks, Monica T. Jones, Matthew W. Hale, Thorsten Lunau, Nico Dragano, Bradley J. Wright
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Pennie Eddy, Eleanor H. Wertheim, Matthew W. Hale, Bradley J. Wright
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2019)
Article
Behavioral Sciences
Matthew W. Hale, Jodi L. Lukkes, Kathleen F. Dady, Kyle J. Kelly, Evan D. Paul, David G. Smith, Jared D. Heinze, Charles L. Raison, Christopher A. Lowry
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Critical Care Medicine
Louise Pham, Sandy R. Shultz, Hyun Ah Kim, Rhys D. Brady, Ryan C. Wortman, Shannyn G. Genders, Matthew W. Hale, Ross D. O'Shea, Elvan Djouma, Maarten van den Buuse, Jarrod E. Church, Brian R. Christie, Grant R. Drummond, Christopher G. Sobey, Stuart J. McDonald
JOURNAL OF NEUROTRAUMA
(2019)
Article
Psychology, Biological
Rachael A. Heckenberg, Matthew W. Hale, Stephen Kent, Bradley J. Wright
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Psychology, Biological
Kathleen Landolt, Paul Maruff, Ben Horan, Michael Kingsley, Glynda Kinsella, Paul D. O'Halloran, Matthew W. Hale, Bradley J. Wright
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Behavioral Sciences
Raymond Kuhnell, Zoe Whitwell, Steven Arnold, Michael I. C. Kingsley, Matthew W. Hale, Morten Wahrendorf, Nico Dragano, Bradley J. Wright
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2020)
Article
Behavioral Sciences
Rachael A. Heckenberg, Matthew W. Hale, Stephen Kent, Bradley J. Wright
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Behavioral Sciences
Rachael A. Heckenberg, Matthew W. Hale, Stephen Kent, Bradley J. Wright
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Multidisciplinary Sciences
L. Van Schaik, C. Kettle, R. Green, W. Sievers, M. W. Hale, H. R. Irving, D. R. Whelan, J. A. Rathner
Summary: The study found that low doses of caffeine can activate brown adipose tissue thermogenesis through the central nervous system, increasing heat production without adverse cardiovascular effects.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Stephanie C. Tran, Emily J. Jaehne, Laura E. Dye, Joanne Wong, Jana S. Bakas, Jemma G. Gasperoni, Matthew W. Hale, Maarten van den Buuse, Sebastian Dworkin, Sylvia V. H. Grommen, Bert De Groef
Summary: Plag1 gene deficiency in mice has mild effects on behavior, with no significant differences in circadian activity levels, locomotion, object recognition, spatial memory, or sociability compared to wild-type mice. However, tests suggest that Plag1 KO mice may have a hearing impairment, indicating a potential role in auditory processes.
Review
Immunology
Jacqueline M. Orian, Claretta S. D'Souza, Pece Kocovski, Guy Krippner, Matthew W. Hale, Xiaowei Wang, Karlheinz Peter
Summary: Platelets play important roles not only in thrombosis and hemostasis, but also in inflammatory and immune reactions. They are central to immune responses and may serve as key mediators in autoimmune disorders, such as their association with multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Behavioral Sciences
Jennyfer M. Payet, Kira-Elise Wilson, Adrian M. Russo, Anthony Angiolino, William Kavanagh-Ryan, Stephen Kent, Christopher A. Lowry, Matthew W. Hale
Summary: This study examined the involvement of serotonergic systems in social behavior and response to SSRI treatment in peri-adolescent female BALB/c mice. The results showed that chronic fluoxetine treatment led to social approach behavior comparable to controls, while acute fluoxetine treatment increased avoidance behavior. Activation of serotonergic neurons in the dorsal raphe nucleus correlated with social approach behavior. More research is needed to understand the effects and mechanisms of chronic SSRI treatment in females.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Mauricio Sepulveda, Elizabeth E. Manning, Andrea Gogos, Matthew Hale, Maarten van den Buuse
Summary: This study evaluated the long-term effects of chronic METH treatment on the serotonin system in the brain using various techniques. The results indicated that METH treatment can lead to long-term or selective effects on brain serotonin systems. METH pretreatment may affect 5-HT1A receptor binding and reduce DRN cell counts selectively in BDNF HET mice.