PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway

PDK1 Determines Collagen-Dependent Platelet Ca2+Signaling and Is Critical to Development of Ischemic Stroke In VivoHighlights

(2016) Patrick Münzer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets

(2016) J. W. Rowley et al.   BLOOD

Ask1 regulates murine platelet granule secretion, thromboxane A2generation, and thrombus formation

(2016) Meghna U. Naik et al.   BLOOD

MiR-128b is down-regulated in gastric cancer and negatively regulates tumour cell viability by targeting PDK1/Akt/NF-κB axis

(2016) Ling Zhang et al.   JOURNAL OF BIOSCIENCES

PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer

(2016) Tao Liu et al.   ONCOLOGY REPORTS

PDK1 Activity Regulates Proliferation, Invasion and Growth of Hemangiomas

(2015) Ningning Zheng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Distinct Pathways Regulate Syk Protein Activation Downstream of Immune Tyrosine Activation Motif (ITAM) and hemITAM Receptors in Platelets

(2015) Bhanu Kanth Manne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDK1 is a potential therapeutic target against angiosarcoma cells

(2015) Makoto Wada et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The PDK1–Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning

(2015) Rossana Zaru et al.   JOURNAL OF IMMUNOLOGY

3-Phosphoinositide-Dependent Kinase 1 Controls Breast Tumor Growth in a Kinase-Dependent but Akt-Independent Manner

(2015) Paolo Armando Gagliardi et al.   NEOPLASIA

MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway

(2014) JIAN ZHOU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction

(2014) Paolo Armando Gagliardi et al.   JOURNAL OF CELL BIOLOGY

Role of Platelets in Inflammation and Cancer: Novel Therapeutic Strategies

(2013) Melania Dovizio et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

PDK1 regulates platelet activation and arterial thrombosis

(2013) X. Chen et al.   BLOOD

Platelets: bridging hemostasis, inflammation, and immunity

(2013) C. N. Jenne et al.   International Journal of Laboratory Hematology

Fucoidan Is a Novel Platelet Agonist for the C-type Lectin-like Receptor 2 (CLEC-2)

(2013) Bhanu Kanth Manne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Role of Pyk2 in Mediating Thromboxane Generation Downstream of Both G12/13and Integrin αIIbβ3 in Platelets

(2013) Soochong Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses

(2013) Carol Dangelmaier et al.   THROMBOSIS AND HAEMOSTASIS

Protein Kinase C Isoform ε Negatively Regulates ADP-Induced Calcium Mobilization and Thromboxane Generation in Platelets

(2012) Yamini S. Bynagari-Settipalli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Impaired thrombin-induced platelet activation and thrombus formation in mice lacking the Ca2+-dependent tyrosine kinase Pyk2

(2012) I. Canobbio et al.   BLOOD

Platelets: key players in vascular inflammation

(2012) Delia Projahn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interaction of PDK1 with Phosphoinositides Is Essential for Neuronal Differentiation but Dispensable for Neuronal Survival

(2012) T. Zurashvili et al.   MOLECULAR AND CELLULAR BIOLOGY

Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation

(2011) A. Mazharian et al.   BLOOD

Targeting PDK1 in Cancer

(2011) C. Raimondi et al.   CURRENT MEDICINAL CHEMISTRY

MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1L613V mutation

(2011) Xue Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of phosphoinositide 3-kinase β in platelet aggregation and thromboxane A2generation mediated by Gisignalling pathways

(2010) Analia Garcia et al.   BIOCHEMICAL JOURNAL

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

(2010) Ayaz Najafov et al.   BIOCHEMICAL JOURNAL

3-Phosphoinositide-Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma

(2009) M. Maurer et al.   CANCER RESEARCH

Reciprocal Negative Regulation of PDK1 and ASK1 Signaling by Direct Interaction and Phosphorylation

(2009) Hyun-A Seong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDK1 Regulates Cell Proliferation and Cell Cycle Progression through Control of Cyclin D1 and p27Kip1Expression

(2008) Kyoko Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathway crosstalk between Ras/Raf and PI3K in promotion of M‐CSF‐induced MEK/ERK‐mediated osteoclast survival

(2008) Elizabeth W. Bradley et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Drug discovery approaches targeting the PI3K/Akt pathway in cancer

(2008) C Garcia-Echeverria et al.   ONCOGENE