Adding levels of complexity enhances robustness and evolvability in a multilevel genotype–phenotype map

Distribution of genotype network sizes in sequence-to-structure genotype–phenotype maps

(2017) Susanna Manrubia et al.   Journal of the Royal Society Interface

The genotype-phenotype map of an evolving digital organism

(2017) Miguel A. Fortuna et al.   PLoS Computational Biology

Genetic Correlations Greatly Increase Mutational Robustness and Can Both Reduce and Enhance Evolvability

(2016) Sam F. Greenbury et al.   PLoS Computational Biology

The organization of biological sequences into constrained and unconstrained parts determines fundamental properties of genotype–phenotype maps

(2015) S. F. Greenbury et al.   Journal of the Royal Society Interface

Dynamics of gene circuits shapes evolvability

(2015) Alba Jiménez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the genotype–phenotype map strongly constrains the evolution of non-coding RNA

(2015) Kamaludin Dingle et al.   Interface Focus

Exhaustive Analysis of a Genotype Space Comprising 1015 Central Carbon Metabolisms Reveals an Organization Conducive to Metabolic Innovation

(2015) Sayed-Rzgar Hosseini et al.   PLoS Computational Biology

A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure

(2014) S. F. Greenbury et al.   Journal of the Royal Society Interface

The Arrival of the Frequent: How Bias in Genotype-Phenotype Maps Can Steer Populations to Local Optima

(2014) Steffen Schaper et al.   PLoS One

Human Genome Variation and the Concept of Genotype Networks

(2014) Giovanni Marco Dall'Olio et al.   PLoS One

toyLIFE: a computational framework to study the multi-level organisation of the genotype-phenotype map

(2014) Clemente F. Arias et al.   Scientific Reports

Robustness, Evolvability, and the Logic of Genetic Regulation

(2013) Joshua L. Payne et al.   ARTIFICIAL LIFE

A latent capacity for evolutionary innovation through exaptation in metabolic systems

(2013) Aditya Barve et al.   NATURE

Is junk DNA bunk? A critique of ENCODE

(2013) W. F. Doolittle   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genotype networks, innovation, and robustness in sulfur metabolism

(2011) João F Matias Rodrigues et al.   BMC Systems Biology

Evolutionary dynamics in a simple model of self-assembly

(2011) Iain G. Johnston et al.   PHYSICAL REVIEW E

Topological Structure of the Space of Phenotypes: The Case of RNA Neutral Networks

(2011) Jacobo Aguirre et al.   PLoS One

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients

(2010) James Cotterell et al.   Molecular Systems Biology

Degeneracy: A design principle for achieving robustness and evolvability

(2009) James Whitacre et al.   JOURNAL OF THEORETICAL BIOLOGY

Statistical mechanics of convergent evolution in spatial patterning

(2009) B. S. Khatri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary Plasticity and Innovations in Complex Metabolic Reaction Networks

(2009) João F. Matias Rodrigues et al.   PLoS Computational Biology

Evaluation of time profile reconstruction from complex two-color microarray designs

(2008) Ana C Fierro et al.   BMC BIOINFORMATICS

Sloppiness, robustness, and evolvability in systems biology

(2008) Bryan C Daniels et al.   CURRENT OPINION IN BIOTECHNOLOGY

Robustness and evolvability: a paradox resolved

(2007) A. Wagner   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES