Article
Chemistry, Multidisciplinary
Carsten Peukert, Sachin Popat Gholap, Ori Green, Lukas Pinkert, Joop van den Heuvel, Marco van Ham, Doron Shabat, Mark Broenstrup
Summary: Conjugating siderophore moieties with enzyme-activatable dioxetanes resulted in trifunctional probes with high signal-to-background ratios, allowing for sensitive and selective detection of bacteria. The efficient iron transport capability into bacteria was confirmed through a growth recovery assay, highlighting the potential applications of these probes in bacterial detection.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Agricultural Engineering
Jian Yang, Shuang-yan Xu, Tao Zhang, Zhuo-qun Zhao, Xiao-jie Xie, Wen-fan Wang, Cheng Zhang, Hua-bao Zheng
Summary: A dual microbial consortium capable of degrading erythromycin was isolated in this study, and the erythromycin biodegradation products were studied. Modified coconut shell activated carbon and the dual bacterial system showed excellent erythromycin removal ability. The immobilized cells achieved 95% removal of erythromycin within 24 hours through pore adsorption, surface complexation, hydrogen bonding, and biodegradation. This study provides a new erythromycin removal agent and sheds light on bacterial cooperation and efficient erythromycin removal.
BIORESOURCE TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mengjie Zhang, Na Ma, Zhongyang Dai, Xiufeng Song, Qingmin Ji, Licheng Li, Rong An
Summary: A highly sensitive gas sensor for volatile organic compounds (VOCs) was developed using immobilized ionic liquid (IL) on functionalized surfaces. The immobilized IL demonstrated significant electrical resistance changes when exposed to acetone and toluene, with different responses on different functionalized surfaces.
Article
Chemistry, Multidisciplinary
James W. Southwell, Reyme Herman, Daniel J. Raines, Justin E. Clarke, Isabelle Boeswald, Thorsten Dreher, Sophie M. Gutenthaler, Nicole Schubert, Jana Seefeldt, Nils Metzler-Nolte, Gavin H. Thomas, Keith S. Wilson, Anne-Kathrin Duhme-Klair
Summary: This study investigates the use of siderophore-linked ruthenium catalysts for the activation of antibacterial prodrugs within cells. It demonstrates that moxifloxacin-based prodrugs can be activated under anaerobic, biologically relevant conditions with the help of these catalysts. Conjugates containing siderophore units based on catechol and azotochelin are found to be the most promising for intracellular prodrug activation.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Shaked Uzi-Gavrilov, Zohar Tik, Omer Sabti, Michael M. Meijler
Summary: Chemical communication between P. aeruginosa and S. aureus in biofilms of cystic fibrosis patients was found to promote cooperation, leading to increased disease severity and antibiotic resistance. Through metabolomics analysis and synthetic validation, it was discovered that S. aureus can convert pyochelin into a compound with reduced affinity for iron, allowing it to coexist more readily with P. aeruginosa and forming robust dual-species biofilms.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Arsha Antony, Tiju Thomas, Cyril Augustine
Summary: Iron is an essential metal for living organisms, but its distribution in tissues is constrained. Insolubility of Fe(III) ions in aqueous systems reduces direct uptake by cells, while free-Fe entities can lead to cell destruction. Therefore, a protective coordination environment is necessary for Fe acquisition, transport, storage, and utilization in tissues. Siderophores are polydentate ligands used by bacterial cells to acquire Fe(III) ions with a high affinity. This research focuses on the coordination chemistry of the siderophore cepabactin (Cep), confirming that the Fe-III(Cep)(3) complex is octahedral and high spin, with Cep's oxygen atoms acting as electron donors.
JOURNAL OF MOLECULAR MODELING
(2023)
Article
Mechanics
Qiang Ma, Yi-Feng Wang, Yi-Bo Wang, Xin He, Shao-Fei Zheng, Yan-Ru Yang, Xiao-Dong Wang, Duu-Jong Lee
Summary: The impact dynamics of water nanodroplets on flat solid surfaces were studied using molecular dynamics simulations, identifying eight different impact outcomes and classifying them into non-bouncing, bouncing, and splash. The splash phenomenon is triggered only when the Weber number exceeds 140.
Review
Chemistry, Medicinal
James W. Southwell, Conor M. Black, Anne-Kathrin Duhme-Klair
Summary: Trojan Horse antibacterials, also known as antibacterial siderophore conjugates, have attracted increasing attention in the field of antibiotics due to their potential to exploit specific pathways in bacteria for active iron uptake and bypass membrane-associated resistance mechanisms. Evaluating the bacterial uptake and identifying the pathways are crucial for improving the design of such antibacterials.
Article
Chemistry, Physical
Jinming Zhang, Wei Ding, Uwe Hampel
Summary: This study deconstructs a complex surface defect into three primary surface defects and uses large-scale Molecular Dynamics simulations to investigate the mechanisms of droplet-solid static friction forces induced by these defects. Three element-wise static friction forces related to the primary surface defects are revealed, and it is found that the static friction force induced by chemical heterogeneity is contact line length dependent while the static friction force induced by atomic structure and topographical defect is contact area dependent. The latter causes energy dissipation and leads to a wiggle movement of the droplet during the static-kinetic friction transition.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Immunology
Lucinda Baatjies, Andre G. Loxton, Monique J. Williams
Summary: Mycobacterium tuberculosis manipulates the host immune response and expresses specific genes during infection. Current immunodiagnostics lack the ability to detect progression from latent infection to active disease, highlighting the need for new tuberculosis biomarkers that can accurately diagnose TB infection and monitor treatment efficacy. Iron regulation by the host plays a crucial role in the susceptibility and outcome of Mtb infection, with certain genes being induced during iron limitation and intracellular growth of Mtb.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Meraat Mehrzad, Mohsen Behpour, Fereshteh Jookar Kashi
Summary: This study investigated the photocatalytic degradation of basic blue 41 dye using N-S co-doped anatase TiO2 nanoparticles immobilized on industrial textile bacteria (ITB). The results showed that the immobilized nanoparticles exhibited higher degradation efficiency, indicating their potential for industrial applications.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Review
Oncology
Valentina Pita-Grisanti, Kaylin Chasser, Trevor Sobol, Zobeida Cruz-Monserrate
Summary: Siderophores are iron chelating molecules produced by bacteria that play a crucial role in iron homeostasis and interspecies competition. They have potential in cancer treatment, but research is limited and their use may have both risks and benefits.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Matthew B. Nodwell, Robert Britton
Summary: A solid-phase platform for the precise synthesis of enterobactin analogues was described, revealing structure-activity relationships for growth promotion in P. aeruginosa by certain HEHC analogues.
ACS INFECTIOUS DISEASES
(2021)
Article
Physics, Applied
Wei Fang, Kaixuan Zhang, Qi Jiang, Cunjing Lv, Chao Sun, Qunyang Li, Yanlin Song, Xi-Qiao Feng
Summary: This Perspective reviews recent advances in the dynamics of drop impact on solid surfaces, analyzing the influences of key factors and the underlying mechanisms of forces and energies, discussing effective strategies to tune dynamic impact behavior.
APPLIED PHYSICS LETTERS
(2022)
Article
Engineering, Environmental
Jennifer L. Goff, Yuwei Wang, Maxim Boyanov, Qiang Yu, Kenneth M. Kemner, Jeremy B. Fein, Nathan Yee
Summary: The study demonstrates that sulfhydryl functional groups in the extracellular polymeric substances of Bacillus subtilis play a key role in the adsorption of tellurite, controlling its binding on bacterial surfaces.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
M. Chinnamani, Priyanka Bhadra, V. T. Fidal, S. Gayathri, Anju Chadha, Enakshi Bhattacharya
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2020)
Review
Pharmacology & Pharmacy
Chandra Kishore, Priyanka Bhadra
Summary: 5-Fluorouracil (5-FU) is the first-line chemotherapy drug for colorectal cancer, but patients often develop resistance to it. Immunotherapy has shown promise in treating colorectal cancer, especially in providing long-term remission for some metastatic CRC patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Neurosciences
Chandra Kishore, Priyanka Bhadra
Summary: Advances in nanotechnology have led to the development of novel diagnosis and treatment methods for diseases like brain cancer, with nanomaterials serving as efficient transport vehicles capable of crossing barriers to deliver drugs. Nanorobots, smart devices resembling red blood cells, can patrol the bloodstream, identify targets, and release drugs to kill cancer cells with precision.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2021)
Article
Chemistry, Physical
Paresh N. Patel, Dipen H. Desai, Nilam C. Patel, Amar G. Deshmukh
Summary: Novel terpyridine scaffolds were synthesized through multicomponent condensation reactions, with comparative studies conducted on two different catalytic processes. The structures of all newly prepared terpyridine molecules were well established through various spectral analysis and single crystal XRD studies.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
P. N. Patel, D. H. Desai, N. C. Patel
Summary: A series of novel terpyridine derivatives of benzofuran were successfully synthesised and Cu(II) complexes were prepared selectively, with analysis conducted using various characterisation techniques. UV-Vis spectral studies were performed on all prepared molecules.
RUSSIAN JOURNAL OF COORDINATION CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
P. N. Patel, K. S. Talati, A. G. Deshmukh, D. H. Desai, N. C. Patel
Summary: An effective secondary amine catalysed approach to the diastereoselective synthesis substituted cyclohexanols was proposed. A steric hindrance driven diastereoselective cross domino reaction gave manifold heteroaryl substituted cyclohexanols with five asymmetric centres in 92-98% yields. The structures of all the synthesized molecules were confirmed by HRMS, NMR and IR spectroscopy methods.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2022)
Article
Chemistry, Organic
P. N. Patel, N. C. Patel, D. H. Desai
Summary: An efficient protocol for the synthesis of novel disperse dyes has been reported, yielding target compounds with high efficiency and purity.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Plant Sciences
Vyoma Mistry, Pragya Tiwari, Paresh Patel, Gajendra Singh Vishwakarma, Geung-Joo Lee, Abhishek Sharma
Summary: Catharanthus roseus synthesizes bioactive therapeutic metabolites known as monoterpenoid indole alkaloids (MIAs), including anti-neoplastic vinblastine and vincristine, as well as antihypertensive ajmalicine. Biotechnological interventions have been used to enhance the production of MIAs in plant systems due to their low in planta concentration. Mutagenesis experiments using chemical and physical agents on C. roseus showed potential effects on the transcriptional modulation of MIA biosynthetic pathways in plants, leading to changes in plant morphology and increased content of specific bioactive compounds.
Article
Chemistry, Physical
Shivani Tandel, Nilam C. Patel, Sriram Kanvah, Paresh N. Patel
Summary: A comparative study was conducted to synthesize novel heteroaryl chalcone derivatives, and it was found that the pyrrolidine catalysed process gave higher yields but was slower. All newly synthesized molecular structures were confirmed using various methods.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Materials Science, Textiles
Nilam C. Patel, Dipen H. Desai, Paresh N. Patel
Summary: This study developed a new protocol for synthesizing disperse dyes through a triple cascade reaction using lawsone and zinc acetate as a catalyst. The novel scaffolds showed efficient dyeing properties on nylon and polyester fibers.
RESEARCH JOURNAL OF TEXTILE AND APPAREL
(2023)
Article
Chemistry, Physical
Shivani N. Tandel, Amar G. Deshmukh, Bhavisha U. Rana, Paresh N. Patel
Summary: The study reports the synthesis of novel chalcone molecules from benzofuran-2-carbaldehyde and various aromatic carbonyl compounds. The Claisen-Schmidt condensation reaction was accelerated by two different catalysts, KOH and pyrrolidine. Pyrrolidine was found to be more efficient than KOH. The structures of the synthesized molecules were determined by various spectral and Single Crystal XRD studies. One of the chalcones was investigated as a hydrazine sensor and demonstrated excellent selectivity. The possible detection mechanism was confirmed by spectral analysis.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Shivani N. Tandel, Dinkal V. Kasundra, Paresh N. Patel
Summary: This study reports the design, synthesis and spectral characterization of benzothiophene substituted pyrazolines. These compounds show strong antimicrobial activity, with 3i exhibiting outstanding activity. These biologically active molecules can be explored as leads for the development of novel antimicrobial drugs.
RESULTS IN CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Paresh N. Patel, Nilam C. Patel, Dipen H. Desai
Summary: This article presents the synthesis of novel disperses dyes using a triple cascade process to prepare dihydropyrimidone derivatives, with isolated yields up to 95%. The structures of the synthesized molecules were confirmed using NMR, HRMS, and IR spectroscopies, and color properties and UV visible spectral studies were conducted.
RESULTS IN CHEMISTRY
(2022)
Article
Chemistry, Organic
P. N. Patel, D. H. Desai, N. C. Patel
Summary: Novel terpyridine derivatives of benzothiazole were synthesized by a simple multicomponent one-pot reaction. All the prepared derivatives were characterized by various instruments, and a copper(II) complex was obtained. UV-visible spectra were recorded for all the synthesized compounds.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Saravanan Krishnan, Paresh N. Patel, Kalpattu K. Balasubramanian, Anju Chadha
Summary: The CpGNP catalyst, prepared by a simple and green method, can selectively reduce nitroarenes and substituted nitroarenes with different functional groups, yielding aryl amines useful for the preparation of pharmaceuticals, polymers, and agrochemicals in high yields under mild conditions. The catalyst exhibits high recyclability, robustness, and long-term stability without any loss in catalytic activity after storage for eight months.
NEW JOURNAL OF CHEMISTRY
(2021)
