The Influence of Higher-Order Epistasis on Biological Fitness Landscape Topography

Detecting High-Order Epistasis in Nonlinear Genotype-Phenotype Maps

(2017) Zachary R. Sailer et al.   GENETICS

High-order epistasis shapes evolutionary trajectories

(2017) Zachary R. Sailer et al.   PLoS Computational Biology

Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits

(2017) Lorin Crawford et al.   PLoS Genetics

Inferring genetic interactions from comparative fitness data

(2017) Kristina Crona et al.   eLife

Detecting High-Order Epistasis in Nonlinear Genotype-Phenotype Maps

(2017) Zachary R. Sailer et al.   GENETICS

Genotypic Context and Epistasis in Individuals and Populations

(2016) Timothy B. Sackton et al.   CELL

On the (un)predictability of a large intragenic fitness landscape

(2016) Claudia Bank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epistasis in protein evolution

(2016) Tyler N. Starr et al.   PROTEIN SCIENCE

The Context-Dependence of Mutations: A Linkage of Formalisms

(2016) Frank J. Poelwijk et al.   PLoS Computational Biology

Adaptive Landscapes of Resistance Genes Change as Antibiotic Concentrations Change

(2015) Portia M. Mira et al.   MOLECULAR BIOLOGY AND EVOLUTION

Quantitative Description of a Protein Fitness Landscape Based on Molecular Features

(2015) María-Rocío Meini et al.   MOLECULAR BIOLOGY AND EVOLUTION

Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes

(2015) Adam C. Palmer et al.   Nature Communications

Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites

(2015) Dave W Anderson et al.   eLife

Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity

(2014) Matthew T. Weirauch et al.   CELL

Fast detection of high-order epistatic interactions in genome-wide association studies using information theoretic measure

(2014) Sangseob Leem et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Empirical fitness landscapes and the predictability of evolution

(2014) J. Arjan G.M. de Visser et al.   NATURE REVIEWS GENETICS

Analysis pipeline for the epistasis search – statistical versus biological filtering

(2014) Xiangqing Sun et al.   Frontiers in Genetics

Should evolutionary geneticists worry about higher-order epistasis?

(2013) Daniel M Weinreich et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Accessible Mutational Trajectories for the Evolution of Pyrimethamine Resistance in the Malaria Parasite Plasmodium vivax

(2013) Pan-Pan Jiang et al.   JOURNAL OF MOLECULAR EVOLUTION

Exact results for amplitude spectra of fitness landscapes

(2013) Johannes Neidhart et al.   JOURNAL OF THEORETICAL BIOLOGY

The Environment Affects Epistatic Interactions to Alter the Topology of an Empirical Fitness Landscape

(2013) Kenneth M. Flynn et al.   PLoS Genetics

VISUALIZING FITNESS LANDSCAPES

(2011) David M. McCandlish   EVOLUTION

Hidden Randomness between Fitness Landscapes Limits Reverse Evolution

(2011) Longzhi Tan et al.   PHYSICAL REVIEW LETTERS

Fitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum

(2011) Marna S. Costanzo et al.   PLoS One

Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population

(2011) A. I. Khan et al.   SCIENCE

Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation

(2011) H.-H. Chou et al.   SCIENCE

Fitness Epistasis and Constraints on Adaptation in a Human Immunodeficiency Virus Type 1 Protein Region

(2010) J. da Silva et al.   GENETICS

Fitness Epistasis among 6 Biosynthetic Loci in the Budding Yeast Saccharomyces cerevisiae

(2010) D. W. Hall et al.   JOURNAL OF HEREDITY

Compensatory Mutations Restore Fitness during the Evolution of Dihydrofolate Reductase

(2010) K. M. Brown et al.   MOLECULAR BIOLOGY AND EVOLUTION

Exploring the Effect of Sex on Empirical Fitness Landscapes

(2009) J. Arjan G. M. de Visser et al.   AMERICAN NATURALIST

Analysis of a complete DNA-protein affinity landscape

(2009) W. Rowe et al.   Journal of the Royal Society Interface

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

(2009) Jamie T. Bridgham et al.   NATURE

Fitness and its role in evolutionary genetics

(2009) H. Allen Orr   NATURE REVIEWS GENETICS

Competition between recombination and epistasis can cause a transition from allele to genotype selection

(2009) R. A. Neher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stepwise acquisition of pyrimethamine resistance in the malaria parasite

(2009) E. R. Lozovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity and Complexity in DNA Recognition by Transcription Factors

(2009) G. Badis et al.   SCIENCE

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

(2008) Paul E O'Maille et al.   Nature Chemical Biology

Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

(2008) Patrick C. Phillips   NATURE REVIEWS GENETICS